BRD-K92571446_WZ-3105_PC3_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

240 genes differentially expressed following the BRD-K92571446_WZ-3105_PC3_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ACKR3 atypical chemokine receptor 3
ADGRF5 adhesion G protein-coupled receptor F5
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ALB albumin
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ANXA4 annexin A4
ANXA9 annexin A9
APOA1 apolipoprotein A-I
APOB apolipoprotein B
ASPN asporin
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
AZU1 azurocidin 1
BCAM basal cell adhesion molecule (Lutheran blood group)
BPI bactericidal/permeability-increasing protein
BPIFA1 BPI fold containing family A, member 1
BTG2 BTG family, member 2
C5AR1 complement component 5a receptor 1
C7 complement component 7
CADM1 cell adhesion molecule 1
CALD1 caldesmon 1
CCL2 chemokine (C-C motif) ligand 2
CCL4 chemokine (C-C motif) ligand 4
CCL5 chemokine (C-C motif) ligand 5
CD209 CD209 molecule
CD24 CD24 molecule
CD52 CD52 molecule
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CEACAM8 carcinoembryonic antigen-related cell adhesion molecule 8
CFB complement factor B
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLC Charcot-Leyden crystal galectin
CLEC10A C-type lectin domain family 10, member A
CLEC4A C-type lectin domain family 4, member A
CLEC5A C-type lectin domain family 5, member A
CLEC7A C-type lectin domain family 7, member A
CLIC5 chloride intracellular channel 5
CLU clusterin
CNOT4 CCR4-NOT transcription complex, subunit 4
COL11A1 collagen, type XI, alpha 1
COL14A1 collagen, type XIV, alpha 1
COL4A5 collagen, type IV, alpha 5
COL4A6 collagen, type IV, alpha 6
COL6A1 collagen, type VI, alpha 1
CPA3 carboxypeptidase A3 (mast cell)
CPE carboxypeptidase E
CSTA cystatin A (stefin A)
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL8 chemokine (C-X-C motif) ligand 8
CXCL9 chemokine (C-X-C motif) ligand 9
CYBRD1 cytochrome b reductase 1
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DEFA4 defensin, alpha 4, corticostatin
DHCR24 24-dehydrocholesterol reductase
DKK3 dickkopf WNT signaling pathway inhibitor 3
DNPH1 2'-deoxynucleoside 5'-phosphate N-hydrolase 1
EGR1 early growth response 1
ELANE elastase, neutrophil expressed
ENTPD1 ectonucleoside triphosphate diphosphohydrolase 1
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
ESR1 estrogen receptor 1
F13A1 coagulation factor XIII, A1 polypeptide
FAS Fas cell surface death receptor
FGFR2 fibroblast growth factor receptor 2
FLRT2 fibronectin leucine rich transmembrane protein 2
FN1 fibronectin 1
FOS FBJ murine osteosarcoma viral oncogene homolog
FPR3 formyl peptide receptor 3
FRZB frizzled-related protein
G0S2 G0/G1 switch 2
GADD45B growth arrest and DNA-damage-inducible, beta
GAS6 growth arrest-specific 6
GJA1 gap junction protein, alpha 1, 43kDa
GPNMB glycoprotein (transmembrane) nmb
GREM1 gremlin 1, DAN family BMP antagonist
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H3H histone cluster 1, H3h
HIST2H2BE histone cluster 2, H2be
HLA-C major histocompatibility complex, class I, C
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HLA-F major histocompatibility complex, class I, F
HSPA6 heat shock 70kDa protein 6 (HSP70B')
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IDO1 indoleamine 2,3-dioxygenase 1
IDS iduronate 2-sulfatase
IFITM1 interferon induced transmembrane protein 1
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP3 insulin-like growth factor binding protein 3
IGHM immunoglobulin heavy constant mu
IGL immunoglobulin lambda locus
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
ITM2A integral membrane protein 2A
ITM2C integral membrane protein 2C
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KCNK3 potassium channel, two pore domain subfamily K, member 3
LAMP2 lysosomal-associated membrane protein 2
LAMP5 lysosomal-associated membrane protein family, member 5
LDOC1 leucine zipper, down-regulated in cancer 1
LYN LYN proto-oncogene, Src family tyrosine kinase
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MEIS2 Meis homeobox 2
METTL7A methyltransferase like 7A
MGAM maltase-glucoamylase
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MME membrane metallo-endopeptidase
MMP9 matrix metallopeptidase 9
MOXD1 monooxygenase, DBH-like 1
MPO myeloperoxidase
MS4A3 membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)
MXI1 MAX interactor 1, dimerization protein
NCF4 neutrophil cytosolic factor 4, 40kDa
NQO2 NAD(P)H dehydrogenase, quinone 2
NR4A2 nuclear receptor subfamily 4, group A, member 2
OGN osteoglycin
OLFM4 olfactomedin 4
ORM1 orosomucoid 1
PCBP2 poly(rC) binding protein 2
PEG10 paternally expressed 10
PEG3 paternally expressed 3
PPP1R16B protein phosphatase 1, regulatory subunit 16B
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
PTN pleiotrophin
PTPRC protein tyrosine phosphatase, receptor type, C
PYCARD PYD and CARD domain containing
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RGCC regulator of cell cycle
RGS16 regulator of G-protein signaling 16
RHOB ras homolog family member B
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1
SCG5 secretogranin V
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SDC2 syndecan 2
SELENBP1 selenium binding protein 1
SEPP1 selenoprotein P, plasma, 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SFRP4 secreted frizzled-related protein 4
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLPI secretory leukocyte peptidase inhibitor
SNN stannin
SOX17 SRY (sex determining region Y)-box 17
SPP1 secreted phosphoprotein 1
STAR steroidogenic acute regulatory protein
TF transferrin
TFPI2 tissue factor pathway inhibitor 2
THAP11 THAP domain containing 11
THBS1 thrombospondin 1
THY1 Thy-1 cell surface antigen
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TPP1 tripeptidyl peptidase I
TRD T cell receptor delta locus
TRDV3 T cell receptor delta variable 3
TSPAN7 tetraspanin 7
TUSC3 tumor suppressor candidate 3
VEGFA vascular endothelial growth factor A
VTCN1 V-set domain containing T cell activation inhibitor 1
WBP2 WW domain binding protein 2
WT1 Wilms tumor 1
ZBED2 zinc finger, BED-type containing 2
ZFPM2 zinc finger protein, FOG family member 2
ZNF423 zinc finger protein 423

decreased expression

Symbol Name
AIM1 absent in melanoma 1
ALCAM activated leukocyte cell adhesion molecule
ARMCX6 armadillo repeat containing, X-linked 6
ASCC3 activating signal cointegrator 1 complex subunit 3
BLMH bleomycin hydrolase
C8ORF4 chromosome 8 open reading frame 4
CANT1 calcium activated nucleotidase 1
CCNA2 cyclin A2
CDC25B cell division cycle 25B
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CHEK2 checkpoint kinase 2
CTBP2 C-terminal binding protein 2
CXCL14 chemokine (C-X-C motif) ligand 14
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1)
DKK1 dickkopf WNT signaling pathway inhibitor 1
E2F2 E2F transcription factor 2
F2RL1 coagulation factor II (thrombin) receptor-like 1
FSTL1 follistatin-like 1
HOXB7 homeobox B7
HOXC6 homeobox C6
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
ITGA6 integrin, alpha 6
JADE2 jade family PHD finger 2
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
LBR lamin B receptor
MARCKS myristoylated alanine-rich protein kinase C substrate
MELK maternal embryonic leucine zipper kinase
MGLL monoglyceride lipase
MTERF3 mitochondrial transcription termination factor 3
MUC5B mucin 5B, oligomeric mucus/gel-forming
MYO10 myosin X
NOSIP nitric oxide synthase interacting protein
NOTCH2 notch 2
NRIP1 nuclear receptor interacting protein 1
NUP62 nucleoporin 62kDa
PLA2G16 phospholipase A2, group XVI
PLAC8 placenta-specific 8
PLK1 polo-like kinase 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PROM1 prominin 1
PTER phosphotriesterase related
RAB4A RAB4A, member RAS oncogene family
RASA1 RAS p21 protein activator (GTPase activating protein) 1
RHOF ras homolog family member F (in filopodia)
RPL36AL ribosomal protein L36a-like
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SMAD3 SMAD family member 3
SRP54 signal recognition particle 54kDa
SRSF5 serine/arginine-rich splicing factor 5
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TBC1D4 TBC1 domain family, member 4
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFF1 trefoil factor 1
TMEM97 transmembrane protein 97
TMX4 thioredoxin-related transmembrane protein 4
TNPO1 transportin 1
TOMM70A translocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae)
TRAPPC3 trafficking protein particle complex 3
USP1 ubiquitin specific peptidase 1
USP22 ubiquitin specific peptidase 22
USP7 ubiquitin specific peptidase 7 (herpes virus-associated)
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa
XPO1 exportin 1
ZNF185 zinc finger protein 185 (LIM domain)