BRD-K92571446_WZ-3105_MDAMB231_3_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

150 genes differentially expressed following the BRD-K92571446_WZ-3105_MDAMB231_3_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
AK1 adenylate kinase 1
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALOX5AP arachidonate 5-lipoxygenase-activating protein
APOC1 apolipoprotein C-I
AQP9 aquaporin 9
ASNS asparagine synthetase (glutamine-hydrolyzing)
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CFH complement factor H
COL1A2 collagen, type I, alpha 2
CPA3 carboxypeptidase A3 (mast cell)
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
ECM2 extracellular matrix protein 2, female organ and adipocyte specific
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EPCAM epithelial cell adhesion molecule
FAS Fas cell surface death receptor
FBLN1 fibulin 1
FCGRT Fc fragment of IgG, receptor, transporter, alpha
FOLR1 folate receptor 1 (adult)
G0S2 G0/G1 switch 2
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
HSD17B4 hydroxysteroid (17-beta) dehydrogenase 4
IL1B interleukin 1, beta
ITM2A integral membrane protein 2A
ITM2C integral membrane protein 2C
LPL lipoprotein lipase
LRRC15 leucine rich repeat containing 15
LRRC17 leucine rich repeat containing 17
LTBP3 latent transforming growth factor beta binding protein 3
MXRA5 matrix-remodelling associated 5
NUPR1 nuclear protein, transcriptional regulator, 1
PAM peptidylglycine alpha-amidating monooxygenase
PKIA protein kinase (cAMP-dependent, catalytic) inhibitor alpha
PLS3 plastin 3
PSENEN presenilin enhancer gamma secretase subunit
PSPH phosphoserine phosphatase
PTGDS prostaglandin D2 synthase 21kDa (brain)
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SEPP1 selenoprotein P, plasma, 1
SEPW1 selenoprotein W, 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SORD sorbitol dehydrogenase
SPINT2 serine peptidase inhibitor, Kunitz type, 2
STEAP1 six transmembrane epithelial antigen of the prostate 1
TMEM47 transmembrane protein 47
TSPAN13 tetraspanin 13
WFDC2 WAP four-disulfide core domain 2

decreased expression

Symbol Name
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5
ADM adrenomedullin
ADO 2-aminoethanethiol (cysteamine) dioxygenase
AHNAK2 AHNAK nucleoprotein 2
AHR aryl hydrocarbon receptor
AREG amphiregulin
ARF6 ADP-ribosylation factor 6
ARL4C ADP-ribosylation factor-like 4C
BMP2 bone morphogenetic protein 2
BMP4 bone morphogenetic protein 4
BTG1 B-cell translocation gene 1, anti-proliferative
C1ORF106 chromosome 1 open reading frame 106
CCNE2 cyclin E2
CD24 CD24 molecule
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CDC42EP4 CDC42 effector protein (Rho GTPase binding) 4
CDCA4 cell division cycle associated 4
CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CXCL8 chemokine (C-X-C motif) ligand 8
CXCR4 chemokine (C-X-C motif) receptor 4
DDIT4 DNA-damage-inducible transcript 4
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNMBP dynamin binding protein
DUSP10 dual specificity phosphatase 10
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
E2F2 E2F transcription factor 2
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
FASTKD5 FAST kinase domains 5
FOSL1 FOS-like antigen 1
FOXC1 forkhead box C1
FOXJ3 forkhead box J3
FOXO1 forkhead box O1
FOXO3 forkhead box O3
FZD7 frizzled class receptor 7
GADD45B growth arrest and DNA-damage-inducible, beta
GATA6 GATA binding protein 6
GEM GTP binding protein overexpressed in skeletal muscle
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
GTF2B general transcription factor IIB
HES1 hes family bHLH transcription factor 1
IER2 immediate early response 2
IER5 immediate early response 5
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IRS2 insulin receptor substrate 2
JADE2 jade family PHD finger 2
JAG1 jagged 1
KLF10 Kruppel-like factor 10
KRT6B keratin 6B, type II
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MCL1 myeloid cell leukemia 1
MED17 mediator complex subunit 17
MYC v-myc avian myelocytomatosis viral oncogene homolog
NET1 neuroepithelial cell transforming 1
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NGDN neuroguidin, EIF4E binding protein
NR4A2 nuclear receptor subfamily 4, group A, member 2
NUP62 nucleoporin 62kDa
NUP85 nucleoporin 85kDa
NXT1 nuclear transport factor 2-like export factor 1
PDGFA platelet-derived growth factor alpha polypeptide
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLK2 polo-like kinase 2
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTPRO protein tyrosine phosphatase, receptor type, O
RBM15 RNA binding motif protein 15
RBM7 RNA binding motif protein 7
SC5D sterol-C5-desaturase
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERTAD2 SERTA domain containing 2
SFRP1 secreted frizzled-related protein 1
SGK1 serum/glucocorticoid regulated kinase 1
SIK1 salt-inducible kinase 1
SMAD3 SMAD family member 3
SMG8 SMG8 nonsense mediated mRNA decay factor
SNAI2 snail family zinc finger 2
SPRY2 sprouty homolog 2 (Drosophila)
TACSTD2 tumor-associated calcium signal transducer 2
TBP TATA box binding protein
TBPL1 TBP-like 1
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
THBS1 thrombospondin 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TMEM2 transmembrane protein 2
WEE1 WEE1 G2 checkpoint kinase
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1
ZFP36L2 ZFP36 ring finger protein-like 2