BRD-K92571446_WZ-3105_MDAMB231_3_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

107 genes differentially expressed following the BRD-K92571446_WZ-3105_MDAMB231_3_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ACSM3 acyl-CoA synthetase medium-chain family member 3
APOC1 apolipoprotein C-I
BEX1 brain expressed, X-linked 1
CA12 carbonic anhydrase XII
CA2 carbonic anhydrase II
CD53 CD53 molecule
COMP cartilage oligomeric matrix protein
CXCL12 chemokine (C-X-C motif) ligand 12
EIF5A eukaryotic translation initiation factor 5A
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EPCAM epithelial cell adhesion molecule
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GAS6 growth arrest-specific 6
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GPX3 glutathione peroxidase 3
H1F0 H1 histone family, member 0
HIST1H4C histone cluster 1, H4c
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IGF1 insulin-like growth factor 1 (somatomedin C)
IL1B interleukin 1, beta
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains)
ITM2A integral membrane protein 2A
ITM2C integral membrane protein 2C
JAM3 junctional adhesion molecule 3
LPL lipoprotein lipase
MAL mal, T-cell differentiation protein
MDK midkine (neurite growth-promoting factor 2)
METTL7A methyltransferase like 7A
NARFL nuclear prelamin A recognition factor-like
NDRG2 NDRG family member 2
NPR3 natriuretic peptide receptor 3
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
RNASE6 ribonuclease, RNase A family, k6
SCG2 secretogranin II
SEPP1 selenoprotein P, plasma, 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SFRP4 secreted frizzled-related protein 4
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SNAP25 synaptosomal-associated protein, 25kDa
SPINT2 serine peptidase inhibitor, Kunitz type, 2
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
THBS2 thrombospondin 2
THY1 Thy-1 cell surface antigen
TIMP3 TIMP metallopeptidase inhibitor 3
TSPAN13 tetraspanin 13
TXNIP thioredoxin interacting protein
VCAM1 vascular cell adhesion molecule 1

decreased expression

Symbol Name
ADM adrenomedullin
ADRB2 adrenoceptor beta 2, surface
AHNAK2 AHNAK nucleoprotein 2
ARL4A ADP-ribosylation factor-like 4A
ARL4C ADP-ribosylation factor-like 4C
BAG3 BCL2-associated athanogene 3
BCL6 B-cell CLL/lymphoma 6
BHLHE40 basic helix-loop-helix family, member e40
BMP4 bone morphogenetic protein 4
CCNF cyclin F
CD44 CD44 molecule (Indian blood group)
CDC25A cell division cycle 25A
CDCA4 cell division cycle associated 4
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CXCL14 chemokine (C-X-C motif) ligand 14
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
DFNA5 deafness, autosomal dominant 5
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNMBP dynamin binding protein
DST dystonin
DUSP10 dual specificity phosphatase 10
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
DUSP7 dual specificity phosphatase 7
EIF5 eukaryotic translation initiation factor 5
FHL2 four and a half LIM domains 2
FOSL1 FOS-like antigen 1
FZD7 frizzled class receptor 7
GEM GTP binding protein overexpressed in skeletal muscle
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
IER5 immediate early response 5
IRS2 insulin receptor substrate 2
KANK1 KN motif and ankyrin repeat domains 1
LDLR low density lipoprotein receptor
LGALS1 lectin, galactoside-binding, soluble, 1
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NOTCH2 notch 2
NRIP1 nuclear receptor interacting protein 1
NUP62 nucleoporin 62kDa
PCDH7 protocadherin 7
PHLDA1 pleckstrin homology-like domain, family A, member 1
RIN2 Ras and Rab interactor 2
SACS sacsin molecular chaperone
SPRR1A small proline-rich protein 1A
SPRY2 sprouty homolog 2 (Drosophila)
TACC2 transforming, acidic coiled-coil containing protein 2
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TM4SF1 transmembrane 4 L six family member 1
WEE1 WEE1 G2 checkpoint kinase
YBX3 Y box binding protein 3
ZCCHC2 zinc finger, CCHC domain containing 2
ZFP36L1 ZFP36 ring finger protein-like 1