BRD-K92571446_WZ-3105_MDAMB231_3_h_0.12_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

112 genes differentially expressed following the BRD-K92571446_WZ-3105_MDAMB231_3_h_0.12_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
APOC1 apolipoprotein C-I
APOE apolipoprotein E
ASNS asparagine synthetase (glutamine-hydrolyzing)
BCL2A1 BCL2-related protein A1
C9ORF16 chromosome 9 open reading frame 16
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLEC7A C-type lectin domain family 7, member A
CSF2RB colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
CXADR coxsackie virus and adenovirus receptor
CXCL2 chemokine (C-X-C motif) ligand 2
CYBA cytochrome b-245, alpha polypeptide
DEPTOR DEP domain containing MTOR-interacting protein
EIF5A eukaryotic translation initiation factor 5A
FAS Fas cell surface death receptor
HLA-DMB major histocompatibility complex, class II, DM beta
HLA-DOB major histocompatibility complex, class II, DO beta
IDO1 indoleamine 2,3-dioxygenase 1
IL1B interleukin 1, beta
ITM2A integral membrane protein 2A
KIAA0226L KIAA0226-like
MDK midkine (neurite growth-promoting factor 2)
ME2 malic enzyme 2, NAD(+)-dependent, mitochondrial
METTL7A methyltransferase like 7A
MMP12 matrix metallopeptidase 12
MMP9 matrix metallopeptidase 9
MT1M metallothionein 1M
NARS asparaginyl-tRNA synthetase
NLGN4X neuroligin 4, X-linked
NMU neuromedin U
NR4A1 nuclear receptor subfamily 4, group A, member 1
PON2 paraoxonase 2
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RBP1 retinol binding protein 1, cellular
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SNAP25 synaptosomal-associated protein, 25kDa
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
STXBP6 syntaxin binding protein 6 (amisyn)
TRD T cell receptor delta locus
TSPAN13 tetraspanin 13
TWF1 twinfilin actin binding protein 1
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
VCAM1 vascular cell adhesion molecule 1
ZNF589 zinc finger protein 589

decreased expression

Symbol Name
ADRB2 adrenoceptor beta 2, surface
AFF1 AF4/FMR2 family, member 1
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
AREG amphiregulin
ARL4C ADP-ribosylation factor-like 4C
BMP4 bone morphogenetic protein 4
C1ORF106 chromosome 1 open reading frame 106
CAST calpastatin
CCNF cyclin F
CD44 CD44 molecule (Indian blood group)
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CDCA4 cell division cycle associated 4
CTSG cathepsin G
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNMBP dynamin binding protein
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
FAF2 Fas associated factor family member 2
FOSL1 FOS-like antigen 1
FZD7 frizzled class receptor 7
GEM GTP binding protein overexpressed in skeletal muscle
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
GPRC5A G protein-coupled receptor, class C, group 5, member A
HMGA2 high mobility group AT-hook 2
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
IGFBP6 insulin-like growth factor binding protein 6
IGL immunoglobulin lambda locus
IRS2 insulin receptor substrate 2
JADE2 jade family PHD finger 2
KLHL21 kelch-like family member 21
KRT6B keratin 6B, type II
LDLR low density lipoprotein receptor
LMNA lamin A/C
LPIN1 lipin 1
MGLL monoglyceride lipase
MGP matrix Gla protein
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NRG1 neuregulin 1
NUP62 nucleoporin 62kDa
PBX3 pre-B-cell leukemia homeobox 3
PDZK1IP1 PDZK1 interacting protein 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
RIN2 Ras and Rab interactor 2
S100A7 S100 calcium binding protein A7
SAV1 salvador family WW domain containing protein 1
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SERTAD2 SERTA domain containing 2
SOX9 SRY (sex determining region Y)-box 9
SPRY2 sprouty homolog 2 (Drosophila)
STK26 serine/threonine protein kinase 26
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TFF1 trefoil factor 1
TGFBR3 transforming growth factor, beta receptor III
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TM4SF1 transmembrane 4 L six family member 1
TNIP1 TNFAIP3 interacting protein 1
TPBG trophoblast glycoprotein
TSC22D2 TSC22 domain family, member 2
WEE1 WEE1 G2 checkpoint kinase
ZFP36L2 ZFP36 ring finger protein-like 2
ZMIZ1 zinc finger, MIZ-type containing 1