BRD-K92571446_WZ-3105_MDAMB231_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

115 genes differentially expressed following the BRD-K92571446_WZ-3105_MDAMB231_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AQP1 aquaporin 1 (Colton blood group)
ATP8B1 ATPase, aminophospholipid transporter, class I, type 8B, member 1
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
BEX1 brain expressed, X-linked 1
BLNK B-cell linker
CA11 carbonic anhydrase XI
CA12 carbonic anhydrase XII
CA2 carbonic anhydrase II
CD24 CD24 molecule
CD36 CD36 molecule (thrombospondin receptor)
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLIC2 chloride intracellular channel 2
CLU clusterin
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
COL5A2 collagen, type V, alpha 2
COL6A3 collagen, type VI, alpha 3
COLEC12 collectin sub-family member 12
CPA3 carboxypeptidase A3 (mast cell)
CPE carboxypeptidase E
CREG1 cellular repressor of E1A-stimulated genes 1
CRYAB crystallin, alpha B
CSTA cystatin A (stefin A)
CTSZ cathepsin Z
CXCL14 chemokine (C-X-C motif) ligand 14
CYBB cytochrome b-245, beta polypeptide
DCN decorin
DKK3 dickkopf WNT signaling pathway inhibitor 3
DPT dermatopontin
ECHDC2 enoyl CoA hydratase domain containing 2
EIF5A eukaryotic translation initiation factor 5A
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
ESR1 estrogen receptor 1
F13A1 coagulation factor XIII, A1 polypeptide
FBLN1 fibulin 1
FBN2 fibrillin 2
FHL1 four and a half LIM domains 1
GJA1 gap junction protein, alpha 1, 43kDa
GPNMB glycoprotein (transmembrane) nmb
GPX3 glutathione peroxidase 3
GUCY1B3 guanylate cyclase 1, soluble, beta 3
HES1 hes family bHLH transcription factor 1
HIPK1 homeodomain interacting protein kinase 1
HIST1H1C histone cluster 1, H1c
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
IL32 interleukin 32
ISYNA1 inositol-3-phosphate synthase 1
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains)
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
LDB2 LIM domain binding 2
LDOC1 leucine zipper, down-regulated in cancer 1
LOC100505650 uncharacterized LOC100505650
LYZ lysozyme
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MFAP5 microfibrillar associated protein 5
MLF1 myeloid leukemia factor 1
MXRA7 matrix-remodelling associated 7
NPR3 natriuretic peptide receptor 3
PHACTR2 phosphatase and actin regulator 2
PLAGL1 pleiomorphic adenoma gene-like 1
PLBD1 phospholipase B domain containing 1
PRKCB protein kinase C, beta
PRSS8 protease, serine, 8
PTN pleiotrophin
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RPL37A ribosomal protein L37a
SCG2 secretogranin II
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SEPP1 selenoprotein P, plasma, 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SLC12A8 solute carrier family 12, member 8
SLC38A1 solute carrier family 38, member 1
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SPINT1 serine peptidase inhibitor, Kunitz type 1
STC2 stanniocalcin 2
TCF4 transcription factor 4
THBS2 thrombospondin 2
THY1 Thy-1 cell surface antigen
TPD52L1 tumor protein D52-like 1
TPP1 tripeptidyl peptidase I
TSPAN7 tetraspanin 7
TTC39A tetratricopeptide repeat domain 39A
TWIST1 twist family bHLH transcription factor 1
WIF1 WNT inhibitory factor 1

decreased expression

Symbol Name
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD59 CD59 molecule, complement regulatory protein
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
FOSL1 FOS-like antigen 1
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial
IRS2 insulin receptor substrate 2
KIF20A kinesin family member 20A
KYNU kynureninase
PDHX pyruvate dehydrogenase complex, component X
PLK1 polo-like kinase 1
PRKCA protein kinase C, alpha
S100P S100 calcium binding protein P
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TOP2A topoisomerase (DNA) II alpha 170kDa
TPD52L2 tumor protein D52-like 2
TXNDC9 thioredoxin domain containing 9
VGLL4 vestigial-like family member 4