BRD-K92571446_WZ-3105_MDAMB231_24_h_0.12_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

141 genes differentially expressed following the BRD-K92571446_WZ-3105_MDAMB231_24_h_0.12_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR1 atypical chemokine receptor 1 (Duffy blood group)
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AQP1 aquaporin 1 (Colton blood group)
ASRGL1 asparaginase like 1
ATMIN ATM interactor
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
BEX4 brain expressed, X-linked 4
BLNK B-cell linker
BTG2 BTG family, member 2
C4BPA complement component 4 binding protein, alpha
CA12 carbonic anhydrase XII
CADM1 cell adhesion molecule 1
CD24 CD24 molecule
CD48 CD48 molecule
CD52 CD52 molecule
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CGA glycoprotein hormones, alpha polypeptide
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLDN10 claudin 10
CLIC2 chloride intracellular channel 2
CLU clusterin
COL1A2 collagen, type I, alpha 2
COL6A3 collagen, type VI, alpha 3
COLEC12 collectin sub-family member 12
CP ceruloplasmin (ferroxidase)
CPE carboxypeptidase E
CPVL carboxypeptidase, vitellogenic-like
CSF2RB colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
CSTA cystatin A (stefin A)
CXCL9 chemokine (C-X-C motif) ligand 9
CYFIP2 cytoplasmic FMR1 interacting protein 2
DAPK1 death-associated protein kinase 1
DCN decorin
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
EPCAM epithelial cell adhesion molecule
EPHB6 EPH receptor B6
ERBB4 erb-b2 receptor tyrosine kinase 4
EXPH5 exophilin 5
F13A1 coagulation factor XIII, A1 polypeptide
FAM107A family with sequence similarity 107, member A
FAM117A family with sequence similarity 117, member A
FHL1 four and a half LIM domains 1
FOLR1 folate receptor 1 (adult)
GPX3 glutathione peroxidase 3
HCAR3 hydroxycarboxylic acid receptor 3
HIPK1 homeodomain interacting protein kinase 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HOXA5 homeobox A5
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IDO1 indoleamine 2,3-dioxygenase 1
IER3 immediate early response 3
IGFBP5 insulin-like growth factor binding protein 5
IQGAP2 IQ motif containing GTPase activating protein 2
ITM2A integral membrane protein 2A
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KIAA0226L KIAA0226-like
LAMP3 lysosomal-associated membrane protein 3
LDOC1 leucine zipper, down-regulated in cancer 1
LPPR4 lipid phosphate phosphatase-related protein type 4
MAP7 microtubule-associated protein 7
NPR3 natriuretic peptide receptor 3
NSG1 neuron specific gene family member 1
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
NTS neurotensin
OPN3 opsin 3
ORAI2 ORAI calcium release-activated calcium modulator 2
PI3 peptidase inhibitor 3, skin-derived
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRKCB protein kinase C, beta
PROS1 protein S (alpha)
PRSS21 protease, serine, 21 (testisin)
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RBP4 retinol binding protein 4, plasma
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SELL selectin L
SFRP4 secreted frizzled-related protein 4
SH3GL3 SH3-domain GRB2-like 3
SH3YL1 SH3 and SYLF domain containing 1
SIRT3 sirtuin 3
SLC15A2 solute carrier family 15 (oligopeptide transporter), member 2
SLC22A18 solute carrier family 22, member 18
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLPI secretory leukocyte peptidase inhibitor
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SOX17 SRY (sex determining region Y)-box 17
SOX4 SRY (sex determining region Y)-box 4
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
TCF4 transcription factor 4
TRBC1 T cell receptor beta constant 1
TSPAN13 tetraspanin 13
TTC39A tetratricopeptide repeat domain 39A
TWIST1 twist family bHLH transcription factor 1
VNN1 vanin 1
VTCN1 V-set domain containing T cell activation inhibitor 1
WFDC2 WAP four-disulfide core domain 2

decreased expression

Symbol Name
CCNB2 cyclin B2
CDC20 cell division cycle 20
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CENPU centromere protein U
COL13A1 collagen, type XIII, alpha 1
CSE1L CSE1 chromosome segregation 1-like (yeast)
CTBP2 C-terminal binding protein 2
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
F3 coagulation factor III (thromboplastin, tissue factor)
FOSL1 FOS-like antigen 1
GPX1 glutathione peroxidase 1
HN1 hematological and neurological expressed 1
IFI16 interferon, gamma-inducible protein 16
IRS2 insulin receptor substrate 2
JMJD6 jumonji domain containing 6
KIF20A kinesin family member 20A
KPNB1 karyopherin (importin) beta 1
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MID1 midline 1
NPY1R neuropeptide Y receptor Y1
NUP85 nucleoporin 85kDa
PARP2 poly (ADP-ribose) polymerase 2
PCNA proliferating cell nuclear antigen
PDHX pyruvate dehydrogenase complex, component X
PLAU plasminogen activator, urokinase
PSMB7 proteasome (prosome, macropain) subunit, beta type, 7
RET ret proto-oncogene
RIN2 Ras and Rab interactor 2
RRM2 ribonucleotide reductase M2
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC43A3 solute carrier family 43, member 3
SNRPB small nuclear ribonucleoprotein polypeptides B and B1
TACC2 transforming, acidic coiled-coil containing protein 2
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TPX2 TPX2, microtubule-associated
TUBB4B tubulin, beta 4B class IVb
TXLNA taxilin alpha
TXNDC9 thioredoxin domain containing 9