BRD-K92571446_WZ-3105_MDAMB231_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

121 genes differentially expressed following the BRD-K92571446_WZ-3105_MDAMB231_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ADAM12 ADAM metallopeptidase domain 12
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADIRF adipogenesis regulatory factor
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
AQP3 aquaporin 3 (Gill blood group)
AUTS2 autism susceptibility candidate 2
BEX4 brain expressed, X-linked 4
CALCRL calcitonin receptor-like
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
CCR7 chemokine (C-C motif) receptor 7
CD24 CD24 molecule
CGA glycoprotein hormones, alpha polypeptide
COL11A1 collagen, type XI, alpha 1
CTSZ cathepsin Z
DCN decorin
DHRS2 dehydrogenase/reductase (SDR family) member 2
DUSP2 dual specificity phosphatase 2
EFHD1 EF-hand domain family, member D1
ELMO1 engulfment and cell motility 1
ERBB4 erb-b2 receptor tyrosine kinase 4
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
FAP fibroblast activation protein, alpha
FOLR1 folate receptor 1 (adult)
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GFOD1 glucose-fructose oxidoreductase domain containing 1
HES1 hes family bHLH transcription factor 1
HIST1H2BG histone cluster 1, H2bg
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
HMGN5 high mobility group nucleosome binding domain 5
HOXA5 homeobox A5
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IGHM immunoglobulin heavy constant mu
JADE3 jade family PHD finger 3
KLF9 Kruppel-like factor 9
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
KRT14 keratin 14, type I
KRT5 keratin 5, type II
LOC100505650 uncharacterized LOC100505650
MAP7 microtubule-associated protein 7
MARCKS myristoylated alanine-rich protein kinase C substrate
MCOLN1 mucolipin 1
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MME membrane metallo-endopeptidase
MUC1 mucin 1, cell surface associated
OPN3 opsin 3
PAX5 paired box 5
PDK4 pyruvate dehydrogenase kinase, isozyme 4
PER2 period circadian clock 2
PIP prolactin-induced protein
RPS5 ribosomal protein S5
RSL1D1 ribosomal L1 domain containing 1
RUNX3 runt-related transcription factor 3
SCGB2A2 secretoglobin, family 2A, member 2
SERINC5 serine incorporator 5
SH3BGRL SH3 domain binding glutamate-rich protein like
SH3YL1 SH3 and SYLF domain containing 1
SKAP2 src kinase associated phosphoprotein 2
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SLPI secretory leukocyte peptidase inhibitor
SNX11 sorting nexin 11
STC2 stanniocalcin 2
TBC1D2B TBC1 domain family, member 2B
TBX2 T-box 2
TCF4 transcription factor 4
TMEM47 transmembrane protein 47
TPD52 tumor protein D52
TSC22D3 TSC22 domain family, member 3
UGT2B28 UDP glucuronosyltransferase 2 family, polypeptide B28
USP7 ubiquitin specific peptidase 7 (herpes virus-associated)
VWA8 von Willebrand factor A domain containing 8
WDR61 WD repeat domain 61

decreased expression

Symbol Name
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)
ANXA3 annexin A3
CAPN2 calpain 2, (m/II) large subunit
CCNB1 cyclin B1
CCND2 cyclin D2
CD44 CD44 molecule (Indian blood group)
CDC20 cell division cycle 20
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLTB clathrin, light chain B
DKK1 dickkopf WNT signaling pathway inhibitor 1
FOSL1 FOS-like antigen 1
FSTL1 follistatin-like 1
G0S2 G0/G1 switch 2
GAPDH glyceraldehyde-3-phosphate dehydrogenase
GNAS GNAS complex locus
GPX3 glutathione peroxidase 3
GREM1 gremlin 1, DAN family BMP antagonist
IFI44 interferon-induced protein 44
IFI6 interferon, alpha-inducible protein 6
KIAA0101 KIAA0101
LCN2 lipocalin 2
LOXL2 lysyl oxidase-like 2
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MATN2 matrilin 2
MCM3 minichromosome maintenance complex component 3
MXRA7 matrix-remodelling associated 7
NUP85 nucleoporin 85kDa
PCP4 Purkinje cell protein 4
PDLIM4 PDZ and LIM domain 4
PHLDA1 pleckstrin homology-like domain, family A, member 1
PNKP polynucleotide kinase 3'-phosphatase
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
PRPF4 pre-mRNA processing factor 4
PTTG1 pituitary tumor-transforming 1
RAD23B RAD23 homolog B (S. cerevisiae)
RRM2 ribonucleotide reductase M2
SCG5 secretogranin V
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SPP1 secreted phosphoprotein 1
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
SVIL supervillin
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TUBB2A tubulin, beta 2A class IIa
TUBB3 tubulin, beta 3 class III
TUBB6 tubulin, beta 6 class V
ZWINT ZW10 interacting kinetochore protein