BRD-K92571446_WZ-3105_MCF7_3_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

145 genes differentially expressed following the BRD-K92571446_WZ-3105_MCF7_3_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADORA2B adenosine A2b receptor
ALCAM activated leukocyte cell adhesion molecule
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
CAV2 caveolin 2
CD59 CD59 molecule, complement regulatory protein
CDH3 cadherin 3, type 1, P-cadherin (placental)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
COL3A1 collagen, type III, alpha 1
CSTA cystatin A (stefin A)
CTGF connective tissue growth factor
DAD1 defender against cell death 1
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EFNB2 ephrin-B2
EGFR epidermal growth factor receptor
EMP1 epithelial membrane protein 1
ENO1 enolase 1, (alpha)
EPHB2 EPH receptor B2
F3 coagulation factor III (thromboplastin, tissue factor)
FAM3C family with sequence similarity 3, member C
FKBP1A FK506 binding protein 1A, 12kDa
FLRT2 fibronectin leucine rich transmembrane protein 2
FYN FYN proto-oncogene, Src family tyrosine kinase
GNG5 guanine nucleotide binding protein (G protein), gamma 5
GSTM3 glutathione S-transferase mu 3 (brain)
GTF2H5 general transcription factor IIH, polypeptide 5
HBB hemoglobin, beta
HES1 hes family bHLH transcription factor 1
HLA-DMA major histocompatibility complex, class II, DM alpha
HMGA2 high mobility group AT-hook 2
HMGB3 high mobility group box 3
HOXC6 homeobox C6
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
LAPTM4B lysosomal protein transmembrane 4 beta
LEF1 lymphoid enhancer-binding factor 1
LEPR leptin receptor
LPL lipoprotein lipase
MAGEA3 melanoma antigen family A3
MAGED1 melanoma antigen family D1
MARCKSL1 MARCKS-like 1
MDFIC MyoD family inhibitor domain containing
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MLF1 myeloid leukemia factor 1
MTSS1 metastasis suppressor 1
NMU neuromedin U
NRGN neurogranin (protein kinase C substrate, RC3)
PDIA5 protein disulfide isomerase family A, member 5
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLAGL1 pleiomorphic adenoma gene-like 1
PLAT plasminogen activator, tissue
PRDX3 peroxiredoxin 3
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
RBP1 retinol binding protein 1, cellular
RGS2 regulator of G-protein signaling 2
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
SEPP1 selenoprotein P, plasma, 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SPARCL1 SPARC-like 1 (hevin)
STEAP1 six transmembrane epithelial antigen of the prostate 1
TAC1 tachykinin, precursor 1
TLR4 toll-like receptor 4
TNNT1 troponin T type 1 (skeletal, slow)
TPD52L1 tumor protein D52-like 1
TRAC T cell receptor alpha constant
TSC22D1 TSC22 domain family, member 1
TUSC3 tumor suppressor candidate 3
WLS wntless Wnt ligand secretion mediator

decreased expression

Symbol Name
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ADM adrenomedullin
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ARID4B AT rich interactive domain 4B (RBP1-like)
ARL4A ADP-ribosylation factor-like 4A
BEX4 brain expressed, X-linked 4
C1ORF106 chromosome 1 open reading frame 106
CADM1 cell adhesion molecule 1
CCNF cyclin F
CDC25A cell division cycle 25A
CDCA4 cell division cycle associated 4
CHN1 chimerin 1
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CNOT2 CCR4-NOT transcription complex, subunit 2
COL11A1 collagen, type XI, alpha 1
COL5A2 collagen, type V, alpha 2
DENND1B DENN/MADD domain containing 1B
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
ESR1 estrogen receptor 1
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FOS FBJ murine osteosarcoma viral oncogene homolog
GATA3 GATA binding protein 3
GNAS GNAS complex locus
GPM6B glycoprotein M6B
GRWD1 glutamate-rich WD repeat containing 1
HACD1 3-hydroxyacyl-CoA dehydratase 1
IGF1R insulin-like growth factor 1 receptor
IRS2 insulin receptor substrate 2
JADE2 jade family PHD finger 2
JMJD6 jumonji domain containing 6
KAT6B K(lysine) acetyltransferase 6B
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
KRT7 keratin 7, type II
LTF lactotransferrin
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAPK6 mitogen-activated protein kinase 6
MED13 mediator complex subunit 13
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MMP7 matrix metallopeptidase 7
MPHOSPH8 M-phase phosphoprotein 8
NACC2 NACC family member 2, BEN and BTB (POZ) domain containing
NELL2 NEL-like 2 (chicken)
NPTXR neuronal pentraxin receptor
NRCAM neuronal cell adhesion molecule
NRIP1 nuclear receptor interacting protein 1
PBX1 pre-B-cell leukemia homeobox 1
PDGFA platelet-derived growth factor alpha polypeptide
PER2 period circadian clock 2
PLK2 polo-like kinase 2
PPP1R3D protein phosphatase 1, regulatory subunit 3D
PRR15L proline rich 15-like
QPCT glutaminyl-peptide cyclotransferase
RBBP6 retinoblastoma binding protein 6
RBM34 RNA binding motif protein 34
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
RPP38 ribonuclease P/MRP 38kDa subunit
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SEPHS1 selenophosphate synthetase 1
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SESN1 sestrin 1
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SMAD1 SMAD family member 1
SPINK1 serine peptidase inhibitor, Kazal type 1
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SULF1 sulfatase 1
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
SUV420H1 suppressor of variegation 4-20 homolog 1 (Drosophila)
TGM2 transglutaminase 2
TNS3 tensin 3
TRPS1 trichorhinophalangeal syndrome I
UTP14A UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)
ZFP36L2 ZFP36 ring finger protein-like 2
ZMYM2 zinc finger, MYM-type 2
ZNF91 zinc finger protein 91