BRD-K92571446_WZ-3105_MCF7_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

184 genes differentially expressed following the BRD-K92571446_WZ-3105_MCF7_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ADD3 adducin 3 (gamma)
ADI1 acireductone dioxygenase 1
ADO 2-aminoethanethiol (cysteamine) dioxygenase
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1
ASPN asporin
BBX bobby sox homolog (Drosophila)
BHLHE41 basic helix-loop-helix family, member e41
BSG basigin (Ok blood group)
CCL5 chemokine (C-C motif) ligand 5
CD46 CD46 molecule, complement regulatory protein
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CFLAR CASP8 and FADD-like apoptosis regulator
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
COTL1 coactosin-like F-actin binding protein 1
CPM carboxypeptidase M
CSRP2 cysteine and glycine-rich protein 2
CTGF connective tissue growth factor
CTSZ cathepsin Z
CXCL8 chemokine (C-X-C motif) ligand 8
CYR61 cysteine-rich, angiogenic inducer, 61
DKK3 dickkopf WNT signaling pathway inhibitor 3
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
EIF5A eukaryotic translation initiation factor 5A
EPAS1 endothelial PAS domain protein 1
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FABP4 fatty acid binding protein 4, adipocyte
FOLH1 folate hydrolase (prostate-specific membrane antigen) 1
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FST follistatin
GBP1 guanylate binding protein 1, interferon-inducible
GPNMB glycoprotein (transmembrane) nmb
GPX1 glutathione peroxidase 1
GPX3 glutathione peroxidase 3
GSN gelsolin
GUK1 guanylate kinase 1
GUSBP3 glucuronidase, beta pseudogene 3
H2AFV H2A histone family, member V
HDAC9 histone deacetylase 9
HEG1 heart development protein with EGF-like domains 1
HLA-B major histocompatibility complex, class I, B
HLA-C major histocompatibility complex, class I, C
HLA-DMA major histocompatibility complex, class II, DM alpha
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-F major histocompatibility complex, class I, F
HLA-G major histocompatibility complex, class I, G
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IDO1 indoleamine 2,3-dioxygenase 1
IER3 immediate early response 3
IFITM1 interferon induced transmembrane protein 1
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP7 insulin-like growth factor binding protein 7
IL7R interleukin 7 receptor
KCNS3 potassium voltage-gated channel, modifier subfamily S, member 3
LAMP3 lysosomal-associated membrane protein 3
LDHB lactate dehydrogenase B
LYN LYN proto-oncogene, Src family tyrosine kinase
MAOA monoamine oxidase A
MDFIC MyoD family inhibitor domain containing
MMP9 matrix metallopeptidase 9
MSN moesin
MXRA7 matrix-remodelling associated 7
NDRG1 N-myc downstream regulated 1
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
NPDC1 neural proliferation, differentiation and control, 1
NR1D2 nuclear receptor subfamily 1, group D, member 2
NT5E 5'-nucleotidase, ecto (CD73)
PLS3 plastin 3
PLVAP plasmalemma vesicle associated protein
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
PSPH phosphoserine phosphatase
PTCH1 patched 1
RABGAP1L RAB GTPase activating protein 1-like
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RGS1 regulator of G-protein signaling 1
RGS5 regulator of G-protein signaling 5
SAT1 spermidine/spermine N1-acetyltransferase 1
SCPEP1 serine carboxypeptidase 1
SDC2 syndecan 2
SDHAF3 succinate dehydrogenase complex assembly factor 3
SFRP1 secreted frizzled-related protein 1
SFRP4 secreted frizzled-related protein 4
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SPRY4 sprouty homolog 4 (Drosophila)
STAP2 signal transducing adaptor family member 2
STC1 stanniocalcin 1
STEAP1 six transmembrane epithelial antigen of the prostate 1
TEK TEK tyrosine kinase, endothelial
TGFA transforming growth factor, alpha
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM204 transmembrane protein 204
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TPD52 tumor protein D52
TPP1 tripeptidyl peptidase I
TRA2A transformer 2 alpha homolog (Drosophila)
TSPAN4 tetraspanin 4
TSPAN7 tetraspanin 7
TYROBP TYRO protein tyrosine kinase binding protein
VEGFA vascular endothelial growth factor A
WDTC1 WD and tetratricopeptide repeats 1
ZDHHC11 zinc finger, DHHC-type containing 11

decreased expression

Symbol Name
ADGRG2 adhesion G protein-coupled receptor G2
ADNP activity-dependent neuroprotector homeobox
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
AURKA aurora kinase A
BASP1 brain abundant, membrane attached signal protein 1
CCNA2 cyclin A2
CD24 CD24 molecule
CDC123 cell division cycle 123
CDCA4 cell division cycle associated 4
CLU clusterin
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CSE1L CSE1 chromosome segregation 1-like (yeast)
CSTF1 cleavage stimulation factor, 3' pre-RNA, subunit 1, 50kDa
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DCK deoxycytidine kinase
DLK1 delta-like 1 homolog (Drosophila)
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa
FGG fibrinogen gamma chain
FLRT3 fibronectin leucine rich transmembrane protein 3
GATA3 GATA binding protein 3
GCH1 GTP cyclohydrolase 1
GDI2 GDP dissociation inhibitor 2
H2AFX H2A histone family, member X
HSPA8 heat shock 70kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
IDI1 isopentenyl-diphosphate delta isomerase 1
IGF1R insulin-like growth factor 1 receptor
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
IRS2 insulin receptor substrate 2
JCHAIN joining chain of multimeric IgA and IgM
KEAP1 kelch-like ECH-associated protein 1
LTF lactotransferrin
LXN latexin
MREG melanoregulin
NET1 neuroepithelial cell transforming 1
NOL11 nucleolar protein 11
NOTCH2 notch 2
NPY1R neuropeptide Y receptor Y1
NR2F2 nuclear receptor subfamily 2, group F, member 2
NRIP1 nuclear receptor interacting protein 1
NUP62 nucleoporin 62kDa
OPN3 opsin 3
PCNA proliferating cell nuclear antigen
PFDN4 prefoldin subunit 4
RAE1 ribonucleic acid export 1
RPP38 ribonuclease P/MRP 38kDa subunit
S100A9 S100 calcium binding protein A9
S100P S100 calcium binding protein P
SCAND1 SCAN domain containing 1
SCGB2A2 secretoglobin, family 2A, member 2
SESN1 sestrin 1
SLC38A2 solute carrier family 38, member 2
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TBP TATA box binding protein
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TFF1 trefoil factor 1
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TLR4 toll-like receptor 4
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TSKU tsukushi, small leucine rich proteoglycan
TSPYL5 TSPY-like 5
TYMS thymidylate synthetase
UBE2C ubiquitin-conjugating enzyme E2C
UBE2I ubiquitin-conjugating enzyme E2I
UBE2S ubiquitin-conjugating enzyme E2S
USP22 ubiquitin specific peptidase 22
XBP1 X-box binding protein 1