BRD-K92571446_WZ-3105_MCF7_24_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

195 genes differentially expressed following the BRD-K92571446_WZ-3105_MCF7_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ADD3 adducin 3 (gamma)
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ANXA1 annexin A1
ATF3 activating transcription factor 3
BCHE butyrylcholinesterase
C3 complement component 3
C9ORF16 chromosome 9 open reading frame 16
CAV1 caveolin 1, caveolae protein, 22kDa
CCL20 chemokine (C-C motif) ligand 20
CCNA1 cyclin A1
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CD93 CD93 molecule
CFI complement factor I
COL6A2 collagen, type VI, alpha 2
CP ceruloplasmin (ferroxidase)
CPM carboxypeptidase M
CSRP2 cysteine and glycine-rich protein 2
CTGF connective tissue growth factor
CTSB cathepsin B
CXCL8 chemokine (C-X-C motif) ligand 8
CYBRD1 cytochrome b reductase 1
CYR61 cysteine-rich, angiogenic inducer, 61
DDHD2 DDHD domain containing 2
ECM1 extracellular matrix protein 1
EMP1 epithelial membrane protein 1
EMX2 empty spiracles homeobox 2
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FAM162A family with sequence similarity 162, member A
FHL1 four and a half LIM domains 1
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FYN FYN proto-oncogene, Src family tyrosine kinase
GADD45B growth arrest and DNA-damage-inducible, beta
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GPM6A glycoprotein M6A
GPNMB glycoprotein (transmembrane) nmb
GPX1 glutathione peroxidase 1
GUK1 guanylate kinase 1
HCLS1 hematopoietic cell-specific Lyn substrate 1
HCP5 HLA complex P5 (non-protein coding)
HLA-B major histocompatibility complex, class I, B
HLA-C major histocompatibility complex, class I, C
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HLA-DPB1 major histocompatibility complex, class II, DP beta 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HLA-DRA major histocompatibility complex, class II, DR alpha
HLA-E major histocompatibility complex, class I, E
HLA-F major histocompatibility complex, class I, F
HLA-G major histocompatibility complex, class I, G
IFI27 interferon, alpha-inducible protein 27
IFITM1 interferon induced transmembrane protein 1
IFITM3 interferon induced transmembrane protein 3
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP3 insulin-like growth factor binding protein 3
IGFBP7 insulin-like growth factor binding protein 7
ITM2C integral membrane protein 2C
LAMP3 lysosomal-associated membrane protein 3
LAPTM5 lysosomal protein transmembrane 5
LCN2 lipocalin 2
LMO4 LIM domain only 4
LPL lipoprotein lipase
MEIS2 Meis homeobox 2
MFAP5 microfibrillar associated protein 5
MGLL monoglyceride lipase
MME membrane metallo-endopeptidase
MMP1 matrix metallopeptidase 1
MMP9 matrix metallopeptidase 9
MOXD1 monooxygenase, DBH-like 1
MSX1 msh homeobox 1
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1X metallothionein 1X
MXRA5 matrix-remodelling associated 5
MXRA7 matrix-remodelling associated 7
NCAM1 neural cell adhesion molecule 1
NOS3 nitric oxide synthase 3 (endothelial cell)
NR4A3 nuclear receptor subfamily 4, group A, member 3
NT5DC2 5'-nucleotidase domain containing 2
NT5E 5'-nucleotidase, ecto (CD73)
PBLD phenazine biosynthesis-like protein domain containing
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PCP4 Purkinje cell protein 4
PECAM1 platelet/endothelial cell adhesion molecule 1
PLAU plasminogen activator, urokinase
PLVAP plasmalemma vesicle associated protein
PRSS21 protease, serine, 21 (testisin)
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
PTCH1 patched 1
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RGCC regulator of cell cycle
RGS1 regulator of G-protein signaling 1
SAT1 spermidine/spermine N1-acetyltransferase 1
SCG5 secretogranin V
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SGCB sarcoglycan, beta (43kDa dystrophin-associated glycoprotein)
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SPARCL1 SPARC-like 1 (hevin)
SPON2 spondin 2, extracellular matrix protein
SPRY4 sprouty homolog 4 (Drosophila)
STC1 stanniocalcin 1
STEAP1 six transmembrane epithelial antigen of the prostate 1
TBC1D9B TBC1 domain family, member 9B (with GRAM domain)
TFPI2 tissue factor pathway inhibitor 2
THY1 Thy-1 cell surface antigen
TIMP3 TIMP metallopeptidase inhibitor 3
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM45A transmembrane protein 45A
TPP1 tripeptidyl peptidase I
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
WSB1 WD repeat and SOCS box containing 1
WT1 Wilms tumor 1
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
ACBD3 acyl-CoA binding domain containing 3
AMD1 adenosylmethionine decarboxylase 1
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2
ARID4B AT rich interactive domain 4B (RBP1-like)
AURKA aurora kinase A
BASP1 brain abundant, membrane attached signal protein 1
CCNA2 cyclin A2
CD24 CD24 molecule
CDC42EP4 CDC42 effector protein (Rho GTPase binding) 4
CDCA4 cell division cycle associated 4
CENPA centromere protein A
CSTF1 cleavage stimulation factor, 3' pre-RNA, subunit 1, 50kDa
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DBF4 DBF4 zinc finger
DLK1 delta-like 1 homolog (Drosophila)
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
EAPP E2F-associated phosphoprotein
FAM208B family with sequence similarity 208, member B
FBP1 fructose-1,6-bisphosphatase 1
GATA3 GATA binding protein 3
GCH1 GTP cyclohydrolase 1
GDI2 GDP dissociation inhibitor 2
GRWD1 glutamate-rich WD repeat containing 1
GSPT2 G1 to S phase transition 2
HOXC6 homeobox C6
HSPA8 heat shock 70kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
IDI1 isopentenyl-diphosphate delta isomerase 1
IGF1R insulin-like growth factor 1 receptor
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
IRS2 insulin receptor substrate 2
KYNU kynureninase
MAP7 microtubule-associated protein 7
MRPS2 mitochondrial ribosomal protein S2
MRPS30 mitochondrial ribosomal protein S30
MYBPC1 myosin binding protein C, slow type
NET1 neuroepithelial cell transforming 1
NOL11 nucleolar protein 11
NOTCH2 notch 2
NRIP1 nuclear receptor interacting protein 1
OPN3 opsin 3
PBX3 pre-B-cell leukemia homeobox 3
PHF20 PHD finger protein 20
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POP4 processing of precursor 4, ribonuclease P/MRP subunit (S. cerevisiae)
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D
PSMD12 proteasome (prosome, macropain) 26S subunit, non-ATPase, 12
RAE1 ribonucleic acid export 1
RBM34 RNA binding motif protein 34
RPP38 ribonuclease P/MRP 38kDa subunit
SLC38A2 solute carrier family 38, member 2
SMG8 SMG8 nonsense mediated mRNA decay factor
SOX4 SRY (sex determining region Y)-box 4
SSBP2 single-stranded DNA binding protein 2
TBX3 T-box 3
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TFB2M transcription factor B2, mitochondrial
TFF1 trefoil factor 1
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TLR4 toll-like receptor 4
TM4SF1 transmembrane 4 L six family member 1
TOB1 transducer of ERBB2, 1
TPBG trophoblast glycoprotein
TPD52L1 tumor protein D52-like 1
TSPYL5 TSPY-like 5
UBE2C ubiquitin-conjugating enzyme E2C
USP7 ubiquitin specific peptidase 7 (herpes virus-associated)
XBP1 X-box binding protein 1
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
ZNF217 zinc finger protein 217