BRD-K92571446_WZ-3105_MCF10A_3_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

135 genes differentially expressed following the BRD-K92571446_WZ-3105_MCF10A_3_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADD3 adducin 3 (gamma)
ADIRF adipogenesis regulatory factor
ALCAM activated leukocyte cell adhesion molecule
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
ATF3 activating transcription factor 3
CA12 carbonic anhydrase XII
CD36 CD36 molecule (thrombospondin receptor)
CDO1 cysteine dioxygenase type 1
CFB complement factor B
CFD complement factor D (adipsin)
CFH complement factor H
CHEK2 checkpoint kinase 2
COMP cartilage oligomeric matrix protein
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
EGR1 early growth response 1
FABP1 fatty acid binding protein 1, liver
FABP4 fatty acid binding protein 4, adipocyte
FOS FBJ murine osteosarcoma viral oncogene homolog
G0S2 G0/G1 switch 2
GAS6 growth arrest-specific 6
GDE1 glycerophosphodiester phosphodiesterase 1
GJA1 gap junction protein, alpha 1, 43kDa
GPX3 glutathione peroxidase 3
HBB hemoglobin, beta
HIST1H2BD histone cluster 1, H2bd
HSD17B4 hydroxysteroid (17-beta) dehydrogenase 4
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IER3 immediate early response 3
ITM2A integral membrane protein 2A
KRT8 keratin 8, type II
LANCL1 LanC lantibiotic synthetase component C-like 1 (bacterial)
LEPR leptin receptor
LPL lipoprotein lipase
LTA4H leukotriene A4 hydrolase
MDFIC MyoD family inhibitor domain containing
METRN meteorin, glial cell differentiation regulator
METTL7A methyltransferase like 7A
MMP9 matrix metallopeptidase 9
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NID2 nidogen 2 (osteonidogen)
OLFM1 olfactomedin 1
OLFM4 olfactomedin 4
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PEX11A peroxisomal biogenesis factor 11 alpha
PKIA protein kinase (cAMP-dependent, catalytic) inhibitor alpha
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLBD1 phospholipase B domain containing 1
PLCB4 phospholipase C, beta 4
RELN reelin
RHOQ ras homolog family member Q
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
SDC2 syndecan 2
SELENBP1 selenium binding protein 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SLC39A6 solute carrier family 39 (zinc transporter), member 6
STOM stomatin
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VWA5A von Willebrand factor A domain containing 5A
WARS tryptophanyl-tRNA synthetase
ZNF423 zinc finger protein 423

decreased expression

Symbol Name
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3
ARID4B AT rich interactive domain 4B (RBP1-like)
C1ORF106 chromosome 1 open reading frame 106
CCNE1 cyclin E1
CCNE2 cyclin E2
CCNF cyclin F
CDC25A cell division cycle 25A
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CDCA4 cell division cycle associated 4
CDK17 cyclin-dependent kinase 17
CHD7 chromodomain helicase DNA binding protein 7
CHIC2 cysteine-rich hydrophobic domain 2
DDIT4 DNA-damage-inducible transcript 4
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
DUSP7 dual specificity phosphatase 7
DYRK2 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2
FAM208B family with sequence similarity 208, member B
FEM1B fem-1 homolog b (C. elegans)
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FHL2 four and a half LIM domains 2
FOSL1 FOS-like antigen 1
H2AFX H2A histone family, member X
IER5 immediate early response 5
IRS2 insulin receptor substrate 2
JADE2 jade family PHD finger 2
JMJD6 jumonji domain containing 6
KEAP1 kelch-like ECH-associated protein 1
LDLR low density lipoprotein receptor
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAPK6 mitogen-activated protein kinase 6
MCL1 myeloid cell leukemia 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NET1 neuroepithelial cell transforming 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NPTX1 neuronal pentraxin I
NXN nucleoredoxin
PDGFA platelet-derived growth factor alpha polypeptide
PDP1 pyruvate dehyrogenase phosphatase catalytic subunit 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLAGL2 pleiomorphic adenoma gene-like 2
PLK2 polo-like kinase 2
PTPRO protein tyrosine phosphatase, receptor type, O
PTX3 pentraxin 3, long
RAP2B RAP2B, member of RAS oncogene family
RGS2 regulator of G-protein signaling 2
RPP38 ribonuclease P/MRP 38kDa subunit
RREB1 ras responsive element binding protein 1
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SLC38A2 solute carrier family 38, member 2
SMAD3 SMAD family member 3
SPRED2 sprouty-related, EVH1 domain containing 2
SPRY2 sprouty homolog 2 (Drosophila)
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
SYNJ2 synaptojanin 2
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TICAM1 toll-like receptor adaptor molecule 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TM4SF1 transmembrane 4 L six family member 1
TNC tenascin C
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TSC22D2 TSC22 domain family, member 2
VEGFA vascular endothelial growth factor A
WEE1 WEE1 G2 checkpoint kinase
XBP1 X-box binding protein 1
ZFP36L2 ZFP36 ring finger protein-like 2