BRD-K92571446_WZ-3105_MCF10A_24_h_0.37_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

191 genes differentially expressed following the BRD-K92571446_WZ-3105_MCF10A_24_h_0.37_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ACKR3 atypical chemokine receptor 3
ADD3 adducin 3 (gamma)
ADM adrenomedullin
AKAP9 A kinase (PRKA) anchor protein 9
AQP1 aquaporin 1 (Colton blood group)
ATF3 activating transcription factor 3
ATP6V0E2 ATPase, H+ transporting V0 subunit e2
AUTS2 autism susceptibility candidate 2
BAG3 BCL2-associated athanogene 3
BBX bobby sox homolog (Drosophila)
BCL7B B-cell CLL/lymphoma 7B
BLNK B-cell linker
BPGM 2,3-bisphosphoglycerate mutase
C1ORF115 chromosome 1 open reading frame 115
CA1 carbonic anhydrase I
CA12 carbonic anhydrase XII
CD9 CD9 molecule
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CECR1 cat eye syndrome chromosome region, candidate 1
CGA glycoprotein hormones, alpha polypeptide
CLU clusterin
COL1A1 collagen, type I, alpha 1
COL1A2 collagen, type I, alpha 2
COL2A1 collagen, type II, alpha 1
COL3A1 collagen, type III, alpha 1
CSRP2 cysteine and glycine-rich protein 2
CTSB cathepsin B
CTSS cathepsin S
CTSZ cathepsin Z
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
DCN decorin
EGFL6 EGF-like-domain, multiple 6
EXPH5 exophilin 5
FERMT2 fermitin family member 2
FHL1 four and a half LIM domains 1
FN1 fibronectin 1
FUCA1 fucosidase, alpha-L- 1, tissue
GLUL glutamate-ammonia ligase
GPM6B glycoprotein M6B
GPX3 glutathione peroxidase 3
GSN gelsolin
HAPLN1 hyaluronan and proteoglycan link protein 1
HBB hemoglobin, beta
HBD hemoglobin, delta
HILPDA hypoxia inducible lipid droplet-associated
HIPK1 homeodomain interacting protein kinase 1
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BG histone cluster 1, H2bg
HIST1H2BK histone cluster 1, H2bk
HSPA2 heat shock 70kDa protein 2
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IFITM1 interferon induced transmembrane protein 1
IGFBP7 insulin-like growth factor binding protein 7
ITM2C integral membrane protein 2C
IVNS1ABP influenza virus NS1A binding protein
JAG1 jagged 1
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KRT15 keratin 15, type I
KRT19 keratin 19, type I
LAPTM5 lysosomal protein transmembrane 5
LEFTY1 left-right determination factor 1
LPIN1 lipin 1
LTBP1 latent transforming growth factor beta binding protein 1
LXN latexin
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MAP1A microtubule-associated protein 1A
METTL7A methyltransferase like 7A
MMP9 matrix metallopeptidase 9
MT1F metallothionein 1F
MYO5A myosin VA (heavy chain 12, myoxin)
NDRG1 N-myc downstream regulated 1
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
PDLIM1 PDZ and LIM domain 1
PECAM1 platelet/endothelial cell adhesion molecule 1
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLBD1 phospholipase B domain containing 1
PPAP2B phosphatidic acid phosphatase type 2B
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
PTN pleiotrophin
RBP4 retinol binding protein 4, plasma
REEP5 receptor accessory protein 5
RGCC regulator of cell cycle
RNF11 ring finger protein 11
S100A4 S100 calcium binding protein A4
SAT1 spermidine/spermine N1-acetyltransferase 1
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SELENBP1 selenium binding protein 1
SEPP1 selenoprotein P, plasma, 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SH3YL1 SH3 and SYLF domain containing 1
SLC14A1 solute carrier family 14 (urea transporter), member 1 (Kidd blood group)
SLC15A2 solute carrier family 15 (oligopeptide transporter), member 2
SLC35A3 solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SOX4 SRY (sex determining region Y)-box 4
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPARCL1 SPARC-like 1 (hevin)
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
STC1 stanniocalcin 1
SYNE2 spectrin repeat containing, nuclear envelope 2
TF transferrin
TMPRSS2 transmembrane protease, serine 2
TNS1 tensin 1
TSC22D3 TSC22 domain family, member 3
TXNIP thioredoxin interacting protein
VNN1 vanin 1
VWA5A von Willebrand factor A domain containing 5A
WIF1 WNT inhibitory factor 1
XIST X inactive specific transcript (non-protein coding)
YPEL5 yippee-like 5 (Drosophila)
ZFP36L2 ZFP36 ring finger protein-like 2
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ACD adrenocortical dysplasia homolog (mouse)
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
ASCC3 activating signal cointegrator 1 complex subunit 3
ATP5H ATP synthase, H+ transporting, mitochondrial Fo complex, subunit d
BAG2 BCL2-associated athanogene 2
BASP1 brain abundant, membrane attached signal protein 1
BLMH bleomycin hydrolase
C3 complement component 3
CCNA2 cyclin A2
CD24 CD24 molecule
CDC25A cell division cycle 25A
CDC25B cell division cycle 25B
CDC6 cell division cycle 6
CDK4 cyclin-dependent kinase 4
CKLF chemokine-like factor
CYCS cytochrome c, somatic
CYR61 cysteine-rich, angiogenic inducer, 61
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DESI1 desumoylating isopeptidase 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
DUSP5 dual specificity phosphatase 5
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
EMG1 EMG1 N1-specific pseudouridine methyltransferase
FADS1 fatty acid desaturase 1
FEN1 flap structure-specific endonuclease 1
GALE UDP-galactose-4-epimerase
GOLGA8B golgin A8 family, member B
HN1 hematological and neurological expressed 1
HOXC6 homeobox C6
HSPD1 heat shock 60kDa protein 1 (chaperonin)
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
KIF14 kinesin family member 14
KRT7 keratin 7, type II
LAPTM4B lysosomal protein transmembrane 4 beta
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MAMLD1 mastermind-like domain containing 1
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3
MCM3 minichromosome maintenance complex component 3
MELK maternal embryonic leucine zipper kinase
MRPL12 mitochondrial ribosomal protein L12
MRPS12 mitochondrial ribosomal protein S12
MRPS16 mitochondrial ribosomal protein S16
MYBPC1 myosin binding protein C, slow type
NDUFS6 NADH dehydrogenase (ubiquinone) Fe-S protein 6, 13kDa (NADH-coenzyme Q reductase)
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NME1 NME/NM23 nucleoside diphosphate kinase 1
PDCD6 programmed cell death 6
PFKM phosphofructokinase, muscle
PLSCR3 phospholipid scramblase 3
POP5 processing of precursor 5, ribonuclease P/MRP subunit (S. cerevisiae)
PPIC peptidylprolyl isomerase C (cyclophilin C)
PPIF peptidylprolyl isomerase F
PRPF4 pre-mRNA processing factor 4
PSMG1 proteasome (prosome, macropain) assembly chaperone 1
PSPH phosphoserine phosphatase
RAB31 RAB31, member RAS oncogene family
RANBP1 RAN binding protein 1
RFC2 replication factor C (activator 1) 2, 40kDa
S100A2 S100 calcium binding protein A2
SKIV2L superkiller viralicidic activity 2-like (S. cerevisiae)
SLIRP SRA stem-loop interacting RNA binding protein
SRM spermidine synthase
STOML2 stomatin (EPB72)-like 2
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
SUB1 SUB1 homolog (S. cerevisiae)
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast)
TNNT1 troponin T type 1 (skeletal, slow)
TRIP6 thyroid hormone receptor interactor 6
TUBB6 tubulin, beta 6 class V
TYMS thymidylate synthetase