BRD-K92571446_WZ-3105_MCF10A_24_h_0.12_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

202 genes differentially expressed following the BRD-K92571446_WZ-3105_MCF10A_24_h_0.12_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACAA1 acetyl-CoA acyltransferase 1
ADGRG1 adhesion G protein-coupled receptor G1
ADGRG6 adhesion G protein-coupled receptor G6
AIM1 absent in melanoma 1
ALOX15B arachidonate 15-lipoxygenase, type B
ALOX5AP arachidonate 5-lipoxygenase-activating protein
AQP1 aquaporin 1 (Colton blood group)
AQP3 aquaporin 3 (Gill blood group)
ATF3 activating transcription factor 3
ATP6V0E2 ATPase, H+ transporting V0 subunit e2
AUTS2 autism susceptibility candidate 2
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BAG3 BCL2-associated athanogene 3
BCAT1 branched chain amino-acid transaminase 1, cytosolic
BLNK B-cell linker
C1ORF115 chromosome 1 open reading frame 115
C1ORF116 chromosome 1 open reading frame 116
CD59 CD59 molecule, complement regulatory protein
CD9 CD9 molecule
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
COBL cordon-bleu WH2 repeat protein
CTTN cortactin
CX3CL1 chemokine (C-X3-C motif) ligand 1
CYB5R2 cytochrome b5 reductase 2
DEFB1 defensin, beta 1
DHRS2 dehydrogenase/reductase (SDR family) member 2
DMXL1 Dmx-like 1
DSP desmoplakin
EDN1 endothelin 1
FBP1 fructose-1,6-bisphosphatase 1
FCGBP Fc fragment of IgG binding protein
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FLNB filamin B, beta
FN1 fibronectin 1
FOLR1 folate receptor 1 (adult)
GDF15 growth differentiation factor 15
GMPR guanosine monophosphate reductase
GSN gelsolin
H2BFS H2B histone family, member S (pseudogene)
HBB hemoglobin, beta
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BE histone cluster 1, H2be
HIST1H2BF histone cluster 1, H2bf
HIST1H2BG histone cluster 1, H2bg
HIST1H2BH histone cluster 1, H2bh
HIST1H2BK histone cluster 1, H2bk
IFI16 interferon, gamma-inducible protein 16
IFI27 interferon, alpha-inducible protein 27
IFI6 interferon, alpha-inducible protein 6
IFITM1 interferon induced transmembrane protein 1
IFITM2 interferon induced transmembrane protein 2
IGF1R insulin-like growth factor 1 receptor
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
IRF6 interferon regulatory factor 6
IRF7 interferon regulatory factor 7
KIAA1598
KLF6 Kruppel-like factor 6
KRT1 keratin 1, type II
KRT14 keratin 14, type I
KRT16 keratin 16, type I
KRT17 keratin 17, type I
KRT23 keratin 23, type I
KRT5 keratin 5, type II
KRT6A keratin 6A, type II
LAMP3 lysosomal-associated membrane protein 3
LAT2 linker for activation of T cells family, member 2
LINC00341 long intergenic non-protein coding RNA 341
MGLL monoglyceride lipase
MMP7 matrix metallopeptidase 7
MTCL1 microtubule crosslinking factor 1
MUC1 mucin 1, cell surface associated
MYO6 myosin VI
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NRIP3 nuclear receptor interacting protein 3
PI3 peptidase inhibitor 3, skin-derived
PRNP prion protein
PROM1 prominin 1
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTN pleiotrophin
QPRT quinolinate phosphoribosyltransferase
REEP5 receptor accessory protein 5
S100A7 S100 calcium binding protein A7
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A2 secretoglobin, family 2A, member 2
SCPEP1 serine carboxypeptidase 1
SELPLG selectin P ligand
SFN stratifin
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SMS spermine synthase
SOCS1 suppressor of cytokine signaling 1
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPDEF SAM pointed domain containing ETS transcription factor
SPINK5 serine peptidase inhibitor, Kazal type 5
SPRR1A small proline-rich protein 1A
SPRR1B small proline-rich protein 1B
SPTBN1 spectrin, beta, non-erythrocytic 1
SRGN serglycin
STC2 stanniocalcin 2
STK38L serine/threonine kinase 38 like
STOM stomatin
TACSTD2 tumor-associated calcium signal transducer 2
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TGFBR3 transforming growth factor, beta receptor III
TM4SF1 transmembrane 4 L six family member 1
TMEM45A transmembrane protein 45A
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TPM4 tropomyosin 4
TUFT1 tuftelin 1
VTCN1 V-set domain containing T cell activation inhibitor 1
VWA5A von Willebrand factor A domain containing 5A
WFDC1 WAP four-disulfide core domain 1

decreased expression

Symbol Name
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1
ATRAID all-trans retinoic acid-induced differentiation factor
BLMH bleomycin hydrolase
BRCA1 breast cancer 1, early onset
CCNB1 cyclin B1
CCND2 cyclin D2
CDK4 cyclin-dependent kinase 4
CHMP4A charged multivesicular body protein 4A
COA3 cytochrome c oxidase assembly factor 3
COPS6 COP9 signalosome subunit 6
COPS7A COP9 signalosome subunit 7A
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CXCL12 chemokine (C-X-C motif) ligand 12
CYBRD1 cytochrome b reductase 1
DHFR dihydrofolate reductase
EIF5 eukaryotic translation initiation factor 5
EMG1 EMG1 N1-specific pseudouridine methyltransferase
ESD esterase D
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)
GALE UDP-galactose-4-epimerase
GAS1 growth arrest-specific 1
GEMIN6 gem (nuclear organelle) associated protein 6
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GOLGA8A golgin A8 family, member A
GOLGA8B golgin A8 family, member B
GRIA2 glutamate receptor, ionotropic, AMPA 2
GSTA4 glutathione S-transferase alpha 4
GULP1 GULP, engulfment adaptor PTB domain containing 1
H1F0 H1 histone family, member 0
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HOXA5 homeobox A5
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IFRD2 interferon-related developmental regulator 2
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
IRS2 insulin receptor substrate 2
ITGB1BP1 integrin beta 1 binding protein 1
KIAA0101 KIAA0101
LAPTM4B lysosomal protein transmembrane 4 beta
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MCM7 minichromosome maintenance complex component 7
MELK maternal embryonic leucine zipper kinase
MRPL12 mitochondrial ribosomal protein L12
MRPL3 mitochondrial ribosomal protein L3
MRPS16 mitochondrial ribosomal protein S16
MSLN mesothelin
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
NDRG2 NDRG family member 2
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
PFKM phosphofructokinase, muscle
PIGP phosphatidylinositol glycan anchor biosynthesis, class P
PLN phospholamban
PLSCR3 phospholipid scramblase 3
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POP5 processing of precursor 5, ribonuclease P/MRP subunit (S. cerevisiae)
PRIM1 primase, DNA, polypeptide 1 (49kDa)
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
PSMC3IP PSMC3 interacting protein
PSPH phosphoserine phosphatase
PTP4A1 protein tyrosine phosphatase type IVA, member 1
RFC5 replication factor C (activator 1) 5, 36.5kDa
RGS5 regulator of G-protein signaling 5
RNASEH2A ribonuclease H2, subunit A
RPA3 replication protein A3, 14kDa
RPRD1A regulation of nuclear pre-mRNA domain containing 1A
RRM2 ribonucleotide reductase M2
SFRP1 secreted frizzled-related protein 1
SFRP4 secreted frizzled-related protein 4
SOX11 SRY (sex determining region Y)-box 11
SRI sorcin
SRSF1 serine/arginine-rich splicing factor 1
SRSF7 serine/arginine-rich splicing factor 7
TFPI2 tissue factor pathway inhibitor 2
THTPA thiamine triphosphatase
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TMEM258 transmembrane protein 258
TMEM5 transmembrane protein 5
TNNT1 troponin T type 1 (skeletal, slow)
TPI1 triosephosphate isomerase 1
TRMT5 tRNA methyltransferase 5
ZWINT ZW10 interacting kinetochore protein