BRD-K92571446_WZ-3105_HT29_24_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

197 genes differentially expressed following the BRD-K92571446_WZ-3105_HT29_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ALB albumin
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ANPEP alanyl (membrane) aminopeptidase
AP3S1 adaptor-related protein complex 3, sigma 1 subunit
APOB apolipoprotein B
ASPN asporin
ATF3 activating transcription factor 3
CADM1 cell adhesion molecule 1
CBS cystathionine-beta-synthase
CCL20 chemokine (C-C motif) ligand 20
CCL4 chemokine (C-C motif) ligand 4
CEP70 centrosomal protein 70kDa
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLC Charcot-Leyden crystal galectin
CLU clusterin
CMC4 C-x(9)-C motif containing 4
COL11A1 collagen, type XI, alpha 1
CP ceruloplasmin (ferroxidase)
CPE carboxypeptidase E
CPM carboxypeptidase M
CSRP2 cysteine and glycine-rich protein 2
CTBS chitobiase, di-N-acetyl-
CTGF connective tissue growth factor
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1
CTSV cathepsin V
CYBRD1 cytochrome b reductase 1
CYP27B1 cytochrome P450, family 27, subfamily B, polypeptide 1
CYR61 cysteine-rich, angiogenic inducer, 61
DDHD2 DDHD domain containing 2
DDR2 discoidin domain receptor tyrosine kinase 2
DEFA4 defensin, alpha 4, corticostatin
DKK3 dickkopf WNT signaling pathway inhibitor 3
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EFHC1 EF-hand domain (C-terminal) containing 1
EGFL6 EGF-like-domain, multiple 6
EGR1 early growth response 1
EIF5A eukaryotic translation initiation factor 5A
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EPAS1 endothelial PAS domain protein 1
ERAP1 endoplasmic reticulum aminopeptidase 1
F13A1 coagulation factor XIII, A1 polypeptide
FBN2 fibrillin 2
FGG fibrinogen gamma chain
FHL1 four and a half LIM domains 1
FOLR1 folate receptor 1 (adult)
FOS FBJ murine osteosarcoma viral oncogene homolog
GPNMB glycoprotein (transmembrane) nmb
HIST1H1C histone cluster 1, H1c
HIST1H2BC histone cluster 1, H2bc
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
IFITM1 interferon induced transmembrane protein 1
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP5 insulin-like growth factor binding protein 5
IGFBP7 insulin-like growth factor binding protein 7
IL13RA2 interleukin 13 receptor, alpha 2
ISYNA1 inositol-3-phosphate synthase 1
KIAA0226L KIAA0226-like
LAMP3 lysosomal-associated membrane protein 3
LDOC1 leucine zipper, down-regulated in cancer 1
LOX lysyl oxidase
LRRC17 leucine rich repeat containing 17
LTBP1 latent transforming growth factor beta binding protein 1
MEF2C myocyte enhancer factor 2C
MFAP2 microfibrillar-associated protein 2
MME membrane metallo-endopeptidase
MSLN mesothelin
MT1F metallothionein 1F
MXRA7 matrix-remodelling associated 7
NOV nephroblastoma overexpressed
OXCT1 3-oxoacid CoA transferase 1
PDIA5 protein disulfide isomerase family A, member 5
PLAGL1 pleiomorphic adenoma gene-like 1
PLVAP plasmalemma vesicle associated protein
PROS1 protein S (alpha)
PROSC proline synthetase co-transcribed homolog (bacterial)
PRSS21 protease, serine, 21 (testisin)
RBKS ribokinase
RBP4 retinol binding protein 4, plasma
SAT1 spermidine/spermine N1-acetyltransferase 1
SCD5 stearoyl-CoA desaturase 5
SCGB2A1 secretoglobin, family 2A, member 1
SDC2 syndecan 2
SEPP1 selenoprotein P, plasma, 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SFRP4 secreted frizzled-related protein 4
SH3BP5 SH3-domain binding protein 5 (BTK-associated)
SH3YL1 SH3 and SYLF domain containing 1
SHANK2 SH3 and multiple ankyrin repeat domains 2
SKP1 S-phase kinase-associated protein 1
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SOD2 superoxide dismutase 2, mitochondrial
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
STC1 stanniocalcin 1
TCF4 transcription factor 4
TFDP2 transcription factor Dp-2 (E2F dimerization partner 2)
TFPI2 tissue factor pathway inhibitor 2
THY1 Thy-1 cell surface antigen
TMEM45A transmembrane protein 45A
TMSB15A thymosin beta 15a
TPMT thiopurine S-methyltransferase
TTC3 tetratricopeptide repeat domain 3
TUSC3 tumor suppressor candidate 3
TWIST1 twist family bHLH transcription factor 1
VEGFA vascular endothelial growth factor A
VTCN1 V-set domain containing T cell activation inhibitor 1
YPEL5 yippee-like 5 (Drosophila)

decreased expression

Symbol Name
ADO 2-aminoethanethiol (cysteamine) dioxygenase
AGR2 anterior gradient 2
AHNAK AHNAK nucleoprotein
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
AURKA aurora kinase A
CALML3 calmodulin-like 3
CCNA2 cyclin A2
CDC25A cell division cycle 25A
CDC42EP4 CDC42 effector protein (Rho GTPase binding) 4
CDK1 cyclin-dependent kinase 1
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CLTC clathrin, heavy chain (Hc)
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CSE1L CSE1 chromosome segregation 1-like (yeast)
CXCL14 chemokine (C-X-C motif) ligand 14
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
EAPP E2F-associated phosphoprotein
EIF4E eukaryotic translation initiation factor 4E
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FBL fibrillarin
FEN1 flap structure-specific endonuclease 1
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GLOD4 glyoxalase domain containing 4
GPX2 glutathione peroxidase 2
H2AFX H2A histone family, member X
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPA2 heat shock 70kDa protein 2
HSPA8 heat shock 70kDa protein 8
IGFBP4 insulin-like growth factor binding protein 4
IMP3 IMP3, U3 small nucleolar ribonucleoprotein
ITGA6 integrin, alpha 6
KEAP1 kelch-like ECH-associated protein 1
LASP1 LIM and SH3 protein 1
LCN2 lipocalin 2
LTF lactotransferrin
LYZ lysozyme
MARCKSL1 MARCKS-like 1
MGAT2 mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
MLPH melanophilin
MRPL17 mitochondrial ribosomal protein L17
MRPS2 mitochondrial ribosomal protein S2
MRPS30 mitochondrial ribosomal protein S30
MYLK myosin light chain kinase
NAV3 neuron navigator 3
NOTCH2 notch 2
NRIP1 nuclear receptor interacting protein 1
NUP98 nucleoporin 98kDa
PCNA proliferating cell nuclear antigen
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PLK1 polo-like kinase 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRC1 protein regulator of cytokinesis 1
PSMD12 proteasome (prosome, macropain) 26S subunit, non-ATPase, 12
RAB14 RAB14, member RAS oncogene family
S100P S100 calcium binding protein P
SCAND1 SCAN domain containing 1
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SFN stratifin
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SUPT16H suppressor of Ty 16 homolog (S. cerevisiae)
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFF1 trefoil factor 1
TFF3 trefoil factor 3 (intestinal)
TIAM1 T-cell lymphoma invasion and metastasis 1
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TMEM97 transmembrane protein 97
TMPO thymopoietin
TOMM70A translocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae)
TOP2A topoisomerase (DNA) II alpha 170kDa
TOX3 TOX high mobility group box family member 3
TSPAN8 tetraspanin 8
UBE2A ubiquitin-conjugating enzyme E2A
UBE2C ubiquitin-conjugating enzyme E2C
UBE2I ubiquitin-conjugating enzyme E2I
UBE2S ubiquitin-conjugating enzyme E2S
UCK2 uridine-cytidine kinase 2
USP1 ubiquitin specific peptidase 1
WEE1 WEE1 G2 checkpoint kinase
XBP1 X-box binding protein 1
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon