BRD-K92571446_WZ-3105_HS578T_3_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

201 genes differentially expressed following the BRD-K92571446_WZ-3105_HS578T_3_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ABAT 4-aminobutyrate aminotransferase
ADD3 adducin 3 (gamma)
ALCAM activated leukocyte cell adhesion molecule
ANKRD10 ankyrin repeat domain 10
ASPN asporin
ASS1 argininosuccinate synthase 1
BLNK B-cell linker
BRE brain and reproductive organ-expressed (TNFRSF1A modulator)
C3 complement component 3
CA2 carbonic anhydrase II
CERS6 ceramide synthase 6
CFB complement factor B
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLU clusterin
COL11A1 collagen, type XI, alpha 1
COL3A1 collagen, type III, alpha 1
COL5A2 collagen, type V, alpha 2
CREG1 cellular repressor of E1A-stimulated genes 1
CSNK2A2 casein kinase 2, alpha prime polypeptide
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
CYFIP1 cytoplasmic FMR1 interacting protein 1
EIF5A eukaryotic translation initiation factor 5A
FABP1 fatty acid binding protein 1, liver
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GPX1 glutathione peroxidase 1
GSN gelsolin
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains)
LRRC17 leucine rich repeat containing 17
ME2 malic enzyme 2, NAD(+)-dependent, mitochondrial
MEF2C myocyte enhancer factor 2C
MMP9 matrix metallopeptidase 9
MXRA5 matrix-remodelling associated 5
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NID2 nidogen 2 (osteonidogen)
ORM1 orosomucoid 1
PADI2 peptidyl arginine deiminase, type II
PLAT plasminogen activator, tissue
PRDX3 peroxiredoxin 3
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PSIP1 PC4 and SFRS1 interacting protein 1
PTN pleiotrophin
PTPRD protein tyrosine phosphatase, receptor type, D
RAB13 RAB13, member RAS oncogene family
RAP2A RAP2A, member of RAS oncogene family
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RRAGD Ras-related GTP binding D
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SPP1 secreted phosphoprotein 1
SRPX sushi-repeat containing protein, X-linked
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2
TBX2 T-box 2
THY1 Thy-1 cell surface antigen
TMEM45A transmembrane protein 45A
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
VAV3 vav 3 guanine nucleotide exchange factor
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADM adrenomedullin
ADO 2-aminoethanethiol (cysteamine) dioxygenase
ADRB2 adrenoceptor beta 2, surface
AMOTL2 angiomotin like 2
AQP3 aquaporin 3 (Gill blood group)
ARID5B AT rich interactive domain 5B (MRF1-like)
ARL4A ADP-ribosylation factor-like 4A
ARL4C ADP-ribosylation factor-like 4C
ATXN7 ataxin 7
AURKA aurora kinase A
BAG5 BCL2-associated athanogene 5
BAMBI BMP and activin membrane-bound inhibitor
BASP1 brain abundant, membrane attached signal protein 1
BCL6 B-cell CLL/lymphoma 6
BHLHE40 basic helix-loop-helix family, member e40
BTG1 B-cell translocation gene 1, anti-proliferative
CCL2 chemokine (C-C motif) ligand 2
CCNA2 cyclin A2
CCNF cyclin F
CDC25A cell division cycle 25A
CDCA4 cell division cycle associated 4
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN2AIP CDKN2A interacting protein
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
DDIT4 DNA-damage-inducible transcript 4
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLC1 DLC1 Rho GTPase activating protein
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP1 dual specificity phosphatase 1
DUSP7 dual specificity phosphatase 7
E2F3 E2F transcription factor 3
EDN1 endothelin 1
EIF4A1 eukaryotic translation initiation factor 4A1
EIF5 eukaryotic translation initiation factor 5
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
FAM129A family with sequence similarity 129, member A
FASTKD5 FAST kinase domains 5
FEM1B fem-1 homolog b (C. elegans)
FOSL1 FOS-like antigen 1
FZD7 frizzled class receptor 7
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GATA2 GATA binding protein 2
GDF15 growth differentiation factor 15
GEM GTP binding protein overexpressed in skeletal muscle
GREM1 gremlin 1, DAN family BMP antagonist
GRWD1 glutamate-rich WD repeat containing 1
H2AFX H2A histone family, member X
H3F3B H3 histone, family 3B (H3.3B)
HES1 hes family bHLH transcription factor 1
HMOX1 heme oxygenase 1
HOXA5 homeobox A5
HSPB8 heat shock 22kDa protein 8
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IER2 immediate early response 2
IER5 immediate early response 5
INSIG1 insulin induced gene 1
IRS2 insulin receptor substrate 2
JUN jun proto-oncogene
JUNB jun B proto-oncogene
JUND jun D proto-oncogene
KAT6A K(lysine) acetyltransferase 6A
KBTBD2 kelch repeat and BTB (POZ) domain containing 2
KDM3A lysine (K)-specific demethylase 3A
KLF11 Kruppel-like factor 11
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
KLHL21 kelch-like family member 21
KLHL9 kelch-like family member 9
LDLR low density lipoprotein receptor
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAPK6 mitogen-activated protein kinase 6
MCL1 myeloid cell leukemia 1
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NET1 neuroepithelial cell transforming 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NGDN neuroguidin, EIF4E binding protein
NKX3-1 NK3 homeobox 1
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NRIP1 nuclear receptor interacting protein 1
NXT1 nuclear transport factor 2-like export factor 1
PELO pelota homolog (Drosophila)
PFKP phosphofructokinase, platelet
PIM1 Pim-1 proto-oncogene, serine/threonine kinase
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PTGER4 prostaglandin E receptor 4 (subtype EP4)
RBM15 RNA binding motif protein 15
RIN2 Ras and Rab interactor 2
RLF rearranged L-myc fusion
RNF139 ring finger protein 139
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
RYBP RING1 and YY1 binding protein
SAP30 Sin3A-associated protein, 30kDa
SDC4 syndecan 4
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERTAD2 SERTA domain containing 2
SH3BP4 SH3-domain binding protein 4
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC38A2 solute carrier family 38, member 2
SMAD3 SMAD family member 3
SMAD7 SMAD family member 7
SOCS5 suppressor of cytokine signaling 5
SOX4 SRY (sex determining region Y)-box 4
SPHK1 sphingosine kinase 1
SPRY2 sprouty homolog 2 (Drosophila)
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACSTD2 tumor-associated calcium signal transducer 2
TES testin LIM domain protein
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TGFBR3 transforming growth factor, beta receptor III
TGIF1 TGFB-induced factor homeobox 1
TICAM1 toll-like receptor adaptor molecule 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TM4SF1 transmembrane 4 L six family member 1
TMEM70 transmembrane protein 70
TP53BP2 tumor protein p53 binding protein 2
TRD T cell receptor delta locus
TRDV3 T cell receptor delta variable 3
TSC22D2 TSC22 domain family, member 2
TSPYL5 TSPY-like 5
TUFT1 tuftelin 1
VEZF1 vascular endothelial zinc finger 1
WEE1 WEE1 G2 checkpoint kinase
XBP1 X-box binding protein 1
YRDC yrdC N(6)-threonylcarbamoyltransferase domain containing
ZCCHC2 zinc finger, CCHC domain containing 2
ZFAND5 zinc finger, AN1-type domain 5
ZFP36L1 ZFP36 ring finger protein-like 1
ZFP36L2 ZFP36 ring finger protein-like 2
ZNF217 zinc finger protein 217
ZW10 zw10 kinetochore protein