BRD-K92571446_WZ-3105_HS578T_24_h_0.12_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

223 genes differentially expressed following the BRD-K92571446_WZ-3105_HS578T_24_h_0.12_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AAMDC adipogenesis associated, Mth938 domain containing
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8
ADA adenosine deaminase
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADI1 acireductone dioxygenase 1
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase
AOC3 amine oxidase, copper containing 3
AQP1 aquaporin 1 (Colton blood group)
ASPN asporin
BAG2 BCL2-associated athanogene 2
BLNK B-cell linker
C1QTNF3 C1q and tumor necrosis factor related protein 3
CA12 carbonic anhydrase XII
CADM1 cell adhesion molecule 1
CCL8 chemokine (C-C motif) ligand 8
CD24 CD24 molecule
CD36 CD36 molecule (thrombospondin receptor)
CD46 CD46 molecule, complement regulatory protein
CD9 CD9 molecule
CERS6 ceramide synthase 6
CFD complement factor D (adipsin)
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
COBLL1 cordon-bleu WH2 repeat protein-like 1
COL11A1 collagen, type XI, alpha 1
COL14A1 collagen, type XIV, alpha 1
COL1A1 collagen, type I, alpha 1
COL4A5 collagen, type IV, alpha 5
COL6A1 collagen, type VI, alpha 1
COMP cartilage oligomeric matrix protein
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like)
CSRP2 cysteine and glycine-rich protein 2
CST3 cystatin C
CTGF connective tissue growth factor
CTSG cathepsin G
CTSV cathepsin V
CTSZ cathepsin Z
CXCL8 chemokine (C-X-C motif) ligand 8
CYBRD1 cytochrome b reductase 1
DHRS2 dehydrogenase/reductase (SDR family) member 2
DMTF1 cyclin D binding myb-like transcription factor 1
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EGR1 early growth response 1
EPCAM epithelial cell adhesion molecule
EPHA3 EPH receptor A3
ERBB4 erb-b2 receptor tyrosine kinase 4
ETNPPL ethanolamine-phosphate phospho-lyase
F13A1 coagulation factor XIII, A1 polypeptide
FABP4 fatty acid binding protein 4, adipocyte
FAM198B family with sequence similarity 198, member B
FBLN1 fibulin 1
FHL1 four and a half LIM domains 1
FMO2 flavin containing monooxygenase 2 (non-functional)
FRY furry homolog (Drosophila)
G0S2 G0/G1 switch 2
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GLUL glutamate-ammonia ligase
GOLGA8A golgin A8 family, member A
GPC4 glypican 4
GPM6A glycoprotein M6A
GPX3 glutathione peroxidase 3
GRB14 growth factor receptor-bound protein 14
GSN gelsolin
GSTM3 glutathione S-transferase mu 3 (brain)
GULP1 GULP, engulfment adaptor PTB domain containing 1
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
HLA-DMA major histocompatibility complex, class II, DM alpha
HMGN5 high mobility group nucleosome binding domain 5
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1
IER3 immediate early response 3
IFI27 interferon, alpha-inducible protein 27
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFITM1 interferon induced transmembrane protein 1
ISG15 ISG15 ubiquitin-like modifier
ITGAV integrin, alpha V
ITM2A integral membrane protein 2A
LAMA3 laminin, alpha 3
LCN2 lipocalin 2
LEF1 lymphoid enhancer-binding factor 1
LRRC17 leucine rich repeat containing 17
LTBP1 latent transforming growth factor beta binding protein 1
MAN2B1 mannosidase, alpha, class 2B, member 1
METTL7A methyltransferase like 7A
MFAP5 microfibrillar associated protein 5
MMP9 matrix metallopeptidase 9
MXRA5 matrix-remodelling associated 5
MXRA7 matrix-remodelling associated 7
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog
MYO5C myosin VC
NOS3 nitric oxide synthase 3 (endothelial cell)
NUP210 nucleoporin 210kDa
PHKB phosphorylase kinase, beta
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLBD1 phospholipase B domain containing 1
PLIN1 perilipin 1
PLS1 plastin 1
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTN pleiotrophin
REEP1 receptor accessory protein 1
REEP5 receptor accessory protein 5
RNASET2 ribonuclease T2
RPIA ribose 5-phosphate isomerase A
RRAGD Ras-related GTP binding D
S100A9 S100 calcium binding protein A9
SCG2 secretogranin II
SCGB2A2 secretoglobin, family 2A, member 2
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SDHAF3 succinate dehydrogenase complex assembly factor 3
SEPP1 selenoprotein P, plasma, 1
SEPT6 septin 6
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SFRP4 secreted frizzled-related protein 4
SH3BGR SH3 domain binding glutamate-rich protein
SH3BGRL SH3 domain binding glutamate-rich protein like
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPARCL1 SPARC-like 1 (hevin)
SPON1 spondin 1, extracellular matrix protein
SPRR1A small proline-rich protein 1A
SPRR2B small proline-rich protein 2B
SYNGR3 synaptogyrin 3
TCFL5 transcription factor-like 5 (basic helix-loop-helix)
TFF3 trefoil factor 3 (intestinal)
TGFBR3 transforming growth factor, beta receptor III
THBS4 thrombospondin 4
TKTL1 transketolase-like 1
TMBIM6 transmembrane BAX inhibitor motif containing 6
TNC tenascin C
TPD52L1 tumor protein D52-like 1
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
TSPAN1 tetraspanin 1
TSPAN13 tetraspanin 13
TSPAN7 tetraspanin 7
TTC3 tetratricopeptide repeat domain 3
TYROBP TYRO protein tyrosine kinase binding protein
WASF1 WAS protein family, member 1
WLS wntless Wnt ligand secretion mediator
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
ABCF3 ATP-binding cassette, sub-family F (GCN20), member 3
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ACLY ATP citrate lyase
ADGRG2 adhesion G protein-coupled receptor G2
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
ANPEP alanyl (membrane) aminopeptidase
BAG3 BCL2-associated athanogene 3
BASP1 brain abundant, membrane attached signal protein 1
BTBD3 BTB (POZ) domain containing 3
C2CD5 C2 calcium-dependent domain containing 5
C9ORF3 chromosome 9 open reading frame 3
CCNA2 cyclin A2
CCNB2 cyclin B2
CD163 CD163 molecule
CDC25B cell division cycle 25B
CNOT7 CCR4-NOT transcription complex, subunit 7
COA3 cytochrome c oxidase assembly factor 3
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CSE1L CSE1 chromosome segregation 1-like (yeast)
CTBP2 C-terminal binding protein 2
DDIT4 DNA-damage-inducible transcript 4
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLK1 delta-like 1 homolog (Drosophila)
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
EIF6 eukaryotic translation initiation factor 6
ELF5 E74-like factor 5 (ets domain transcription factor)
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FADS1 fatty acid desaturase 1
FGFR2 fibroblast growth factor receptor 2
FGG fibrinogen gamma chain
FOSL1 FOS-like antigen 1
GABRE gamma-aminobutyric acid (GABA) A receptor, epsilon
GARS glycyl-tRNA synthetase
GLOD4 glyoxalase domain containing 4
GLRX glutaredoxin (thioltransferase)
GPX2 glutathione peroxidase 2
HK1 hexokinase 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HSPA8 heat shock 70kDa protein 8
IRS2 insulin receptor substrate 2
KIF1BP KIF1 binding protein
KLF4 Kruppel-like factor 4 (gut)
KRT81 keratin 81, type II
LDLR low density lipoprotein receptor
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MID1 midline 1
MRPL15 mitochondrial ribosomal protein L15
MYO10 myosin X
PCNA proliferating cell nuclear antigen
PDGFA platelet-derived growth factor alpha polypeptide
POU2AF1 POU class 2 associating factor 1
PSMB2 proteasome (prosome, macropain) subunit, beta type, 2
PSMD11 proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
PSMG1 proteasome (prosome, macropain) assembly chaperone 1
PSPH phosphoserine phosphatase
PTX3 pentraxin 3, long
RAE1 ribonucleic acid export 1
RTCB RNA 2',3'-cyclic phosphate and 5'-OH ligase
SCAND1 SCAN domain containing 1
SDC4 syndecan 4
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SMC4 structural maintenance of chromosomes 4
SRGN serglycin
TARS threonyl-tRNA synthetase
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast)
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TLE4 transducin-like enhancer of split 4
TRAM2 translocation associated membrane protein 2
TRAPPC3 trafficking protein particle complex 3
TXLNA taxilin alpha
TXNRD1 thioredoxin reductase 1
TYMS thymidylate synthetase
UBE2C ubiquitin-conjugating enzyme E2C
USP1 ubiquitin specific peptidase 1
USP22 ubiquitin specific peptidase 22
XBP1 X-box binding protein 1