BRD-K92571446_WZ-3105_HS578T_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

194 genes differentially expressed following the BRD-K92571446_WZ-3105_HS578T_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ACKR1 atypical chemokine receptor 1 (Duffy blood group)
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADIPOQ adiponectin, C1Q and collagen domain containing
ADRB2 adrenoceptor beta 2, surface
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase
AQP1 aquaporin 1 (Colton blood group)
ARPP19 cAMP-regulated phosphoprotein, 19kDa
ASPN asporin
ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
BLNK B-cell linker
BMP2 bone morphogenetic protein 2
BST2 bone marrow stromal cell antigen 2
C5ORF30 chromosome 5 open reading frame 30
CA12 carbonic anhydrase XII
CAMP cathelicidin antimicrobial peptide
CCL19 chemokine (C-C motif) ligand 19
CCL20 chemokine (C-C motif) ligand 20
CCL8 chemokine (C-C motif) ligand 8
CD177 CD177 molecule
CD36 CD36 molecule (thrombospondin receptor)
CD44 CD44 molecule (Indian blood group)
CD59 CD59 molecule, complement regulatory protein
CD9 CD9 molecule
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CGA glycoprotein hormones, alpha polypeptide
CHPT1 choline phosphotransferase 1
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
COBLL1 cordon-bleu WH2 repeat protein-like 1
COL11A1 collagen, type XI, alpha 1
COL4A5 collagen, type IV, alpha 5
COMP cartilage oligomeric matrix protein
CPE carboxypeptidase E
CRYBG3 beta-gamma crystallin domain containing 3
CSRP2 cysteine and glycine-rich protein 2
CST3 cystatin C
CTSZ cathepsin Z
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL5 chemokine (C-X-C motif) ligand 5
CXCL8 chemokine (C-X-C motif) ligand 8
CYBA cytochrome b-245, alpha polypeptide
CYBRD1 cytochrome b reductase 1
DEPTOR DEP domain containing MTOR-interacting protein
DUSP4 dual specificity phosphatase 4
EFHD1 EF-hand domain family, member D1
EGR1 early growth response 1
EGR3 early growth response 3
EPCAM epithelial cell adhesion molecule
EPHA3 EPH receptor A3
ERBB4 erb-b2 receptor tyrosine kinase 4
ESR1 estrogen receptor 1
ETNPPL ethanolamine-phosphate phospho-lyase
F13A1 coagulation factor XIII, A1 polypeptide
FABP4 fatty acid binding protein 4, adipocyte
FAM46A family with sequence similarity 46, member A
FBLN1 fibulin 1
FEZ2 fasciculation and elongation protein zeta 2 (zygin II)
FHL1 four and a half LIM domains 1
FRZB frizzled-related protein
FUCA1 fucosidase, alpha-L- 1, tissue
G0S2 G0/G1 switch 2
GPC3 glypican 3
GPM6A glycoprotein M6A
GPX3 glutathione peroxidase 3
GRB14 growth factor receptor-bound protein 14
GRIA2 glutamate receptor, ionotropic, AMPA 2
GSN gelsolin
GULP1 GULP, engulfment adaptor PTB domain containing 1
HBE1 hemoglobin, epsilon 1
HIST1H2BG histone cluster 1, H2bg
HP haptoglobin
HSD11B2 hydroxysteroid (11-beta) dehydrogenase 2
IFITM1 interferon induced transmembrane protein 1
IGF1 insulin-like growth factor 1 (somatomedin C)
IKZF1 IKAROS family zinc finger 1 (Ikaros)
ISG15 ISG15 ubiquitin-like modifier
ITM2A integral membrane protein 2A
KNG1 kininogen 1
KRAS Kirsten rat sarcoma viral oncogene homolog
LAGE3 L antigen family, member 3
LCN2 lipocalin 2
LMO4 LIM domain only 4
LPL lipoprotein lipase
LTBP1 latent transforming growth factor beta binding protein 1
LTF lactotransferrin
MAN1A1 mannosidase, alpha, class 1A, member 1
MEF2C myocyte enhancer factor 2C
MFAP3L microfibrillar-associated protein 3-like
MFAP5 microfibrillar associated protein 5
MMP9 matrix metallopeptidase 9
NTS neurotensin
ORM1 orosomucoid 1
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1
PARP8 poly (ADP-ribose) polymerase family, member 8
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PDK4 pyruvate dehydrogenase kinase, isozyme 4
PI3 peptidase inhibitor 3, skin-derived
PLIN1 perilipin 1
PLK2 polo-like kinase 2
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PTCH1 patched 1
QPRT quinolinate phosphoribosyltransferase
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
REEP5 receptor accessory protein 5
RHOB ras homolog family member B
RNASET2 ribonuclease T2
RRAGD Ras-related GTP binding D
SCGB2A2 secretoglobin, family 2A, member 2
SCUBE2 signal peptide, CUB domain, EGF-like 2
SELENBP1 selenium binding protein 1
SEPP1 selenoprotein P, plasma, 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SFN stratifin
SFRP1 secreted frizzled-related protein 1
SFRP4 secreted frizzled-related protein 4
SH3BGRL SH3 domain binding glutamate-rich protein like
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SOD2 superoxide dismutase 2, mitochondrial
SPARCL1 SPARC-like 1 (hevin)
SPON1 spondin 1, extracellular matrix protein
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TFF1 trefoil factor 1
TFF3 trefoil factor 3 (intestinal)
TIMP3 TIMP metallopeptidase inhibitor 3
TNC tenascin C
TPD52 tumor protein D52
TPD52L1 tumor protein D52-like 1
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
TSPAN1 tetraspanin 1
TSPAN7 tetraspanin 7
TUSC3 tumor suppressor candidate 3
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
AHNAK2 AHNAK nucleoprotein 2
BLVRA biliverdin reductase A
CAST calpastatin
CCNA2 cyclin A2
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
COPB2 coatomer protein complex, subunit beta 2 (beta prime)
DDIT4 DNA-damage-inducible transcript 4
DKK1 dickkopf WNT signaling pathway inhibitor 1
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
ETV5 ets variant 5
FCGBP Fc fragment of IgG binding protein
FGFR2 fibroblast growth factor receptor 2
FHL2 four and a half LIM domains 2
FOSL1 FOS-like antigen 1
GLOD4 glyoxalase domain containing 4
GPX2 glutathione peroxidase 2
GRB10 growth factor receptor-bound protein 10
GSTA4 glutathione S-transferase alpha 4
GTPBP8 GTP-binding protein 8 (putative)
GUSBP11 glucuronidase, beta pseudogene 11
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSPA8 heat shock 70kDa protein 8
IFI16 interferon, gamma-inducible protein 16
IFT57 intraflagellar transport 57
IGHM immunoglobulin heavy constant mu
KRT7 keratin 7, type II
LBH limb bud and heart development
MACF1 microtubule-actin crosslinking factor 1
MID1 midline 1
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MYO10 myosin X
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
PCM1 pericentriolar material 1
PDGFA platelet-derived growth factor alpha polypeptide
PNMA2 paraneoplastic Ma antigen 2
PSMG1 proteasome (prosome, macropain) assembly chaperone 1
PTX3 pentraxin 3, long
PUF60 poly-U binding splicing factor 60KDa
RAB11FIP2 RAB11 family interacting protein 2 (class I)
RPS4Y1 ribosomal protein S4, Y-linked 1
SFTPA2 surfactant protein A2
SFTPC surfactant protein C
SKIV2L superkiller viralicidic activity 2-like (S. cerevisiae)
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SMC4 structural maintenance of chromosomes 4
TACC2 transforming, acidic coiled-coil containing protein 2
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast)
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TSPYL5 TSPY-like 5
TTN titin
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
XBP1 X-box binding protein 1