BRD-K92571446_WZ-3105_HEPG2_24_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

197 genes differentially expressed following the BRD-K92571446_WZ-3105_HEPG2_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
ADD3 adducin 3 (gamma)
ADGRF5 adhesion G protein-coupled receptor F5
AIF1 allograft inflammatory factor 1
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ALDH6A1 aldehyde dehydrogenase 6 family, member A1
ALOX5 arachidonate 5-lipoxygenase
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase
ANGPTL2 angiopoietin-like 2
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ANO1 anoctamin 1, calcium activated chloride channel
ANXA1 annexin A1
APOE apolipoprotein E
AQP1 aquaporin 1 (Colton blood group)
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
ATP6AP1 ATPase, H+ transporting, lysosomal accessory protein 1
C1ORF54 chromosome 1 open reading frame 54
CADM1 cell adhesion molecule 1
CAV1 caveolin 1, caveolae protein, 22kDa
CCL4 chemokine (C-C motif) ligand 4
CD3D CD3d molecule, delta (CD3-TCR complex)
CD4 CD4 molecule
CD84 CD84 molecule
CD9 CD9 molecule
CEP70 centrosomal protein 70kDa
CERS6 ceramide synthase 6
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CKB creatine kinase, brain
CLEC7A C-type lectin domain family 7, member A
CLU clusterin
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
COL6A1 collagen, type VI, alpha 1
COL6A3 collagen, type VI, alpha 3
CPM carboxypeptidase M
CSRP2 cysteine and glycine-rich protein 2
CTSL cathepsin L
CYR61 cysteine-rich, angiogenic inducer, 61
DDHD2 DDHD domain containing 2
EGR1 early growth response 1
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
ENPP4 ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative)
EPAS1 endothelial PAS domain protein 1
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
EXPH5 exophilin 5
F2R coagulation factor II (thrombin) receptor
FAM129A family with sequence similarity 129, member A
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
FCGR1B Fc fragment of IgG, high affinity Ib, receptor (CD64)
FCGR3B Fc fragment of IgG, low affinity IIIb, receptor (CD16b)
FGFR4 fibroblast growth factor receptor 4
FMO2 flavin containing monooxygenase 2 (non-functional)
FOLH1 folate hydrolase (prostate-specific membrane antigen) 1
G0S2 G0/G1 switch 2
GAA glucosidase, alpha; acid
GADD45B growth arrest and DNA-damage-inducible, beta
GATAD1 GATA zinc finger domain containing 1
GM2A GM2 ganglioside activator
GPM6A glycoprotein M6A
GPX3 glutathione peroxidase 3
GSN gelsolin
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
GUK1 guanylate kinase 1
HIST1H1C histone cluster 1, H1c
HIST1H2BC histone cluster 1, H2bc
IFI6 interferon, alpha-inducible protein 6
IFITM1 interferon induced transmembrane protein 1
IGFBP7 insulin-like growth factor binding protein 7
IL2RG interleukin 2 receptor, gamma
IL7R interleukin 7 receptor
ISG15 ISG15 ubiquitin-like modifier
ITM2A integral membrane protein 2A
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
LAMP3 lysosomal-associated membrane protein 3
LDHB lactate dehydrogenase B
LDOC1 leucine zipper, down-regulated in cancer 1
LEF1 lymphoid enhancer-binding factor 1
LGMN legumain
LRPAP1 low density lipoprotein receptor-related protein associated protein 1
LTBP1 latent transforming growth factor beta binding protein 1
MAN2B1 mannosidase, alpha, class 2B, member 1
MAN2B2 mannosidase, alpha, class 2B, member 2
MME membrane metallo-endopeptidase
MMP12 matrix metallopeptidase 12
MMP9 matrix metallopeptidase 9
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog
NEBL nebulette
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PCYOX1 prenylcysteine oxidase 1
PDIA5 protein disulfide isomerase family A, member 5
PER2 period circadian clock 2
PER3 period circadian clock 3
PLCB4 phospholipase C, beta 4
PLVAP plasmalemma vesicle associated protein
POSTN periostin, osteoblast specific factor
PPT1 palmitoyl-protein thioesterase 1
PROS1 protein S (alpha)
PTN pleiotrophin
PTP4A2 protein tyrosine phosphatase type IVA, member 2
RCAN1 regulator of calcineurin 1
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
SCARB2 scavenger receptor class B, member 2
SELE selectin E
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SHANK2 SH3 and multiple ankyrin repeat domains 2
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SPARCL1 SPARC-like 1 (hevin)
SPP1 secreted phosphoprotein 1
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
STC1 stanniocalcin 1
SULF1 sulfatase 1
TFDP2 transcription factor Dp-2 (E2F dimerization partner 2)
TIMP3 TIMP metallopeptidase inhibitor 3
TMBIM6 transmembrane BAX inhibitor motif containing 6
TMSB15A thymosin beta 15a
TRBC1 T cell receptor beta constant 1
TRD T cell receptor delta locus
TRDV3 T cell receptor delta variable 3
TRPS1 trichorhinophalangeal syndrome I
TSPAN31 tetraspanin 31
TSPAN4 tetraspanin 4
TSPAN7 tetraspanin 7
TTC3 tetratricopeptide repeat domain 3
TUSC3 tumor suppressor candidate 3
TYROBP TYRO protein tyrosine kinase binding protein
VTCN1 V-set domain containing T cell activation inhibitor 1
VWF von Willebrand factor
WIF1 WNT inhibitory factor 1
ZNF264 zinc finger protein 264
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AMD1 adenosylmethionine decarboxylase 1
ASCC3 activating signal cointegrator 1 complex subunit 3
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
AURKA aurora kinase A
CDC25A cell division cycle 25A
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CHEK2 checkpoint kinase 2
CKS2 CDC28 protein kinase regulatory subunit 2
CLTA clathrin, light chain A
CLTC clathrin, heavy chain (Hc)
CSTF1 cleavage stimulation factor, 3' pre-RNA, subunit 1, 50kDa
DEFA5 defensin, alpha 5, Paneth cell-specific
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
ERBB2 erb-b2 receptor tyrosine kinase 2
F2RL1 coagulation factor II (thrombin) receptor-like 1
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type
GLOD4 glyoxalase domain containing 4
GLRX glutaredoxin (thioltransferase)
GRWD1 glutamate-rich WD repeat containing 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HSPA8 heat shock 70kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
IGF1R insulin-like growth factor 1 receptor
IRS2 insulin receptor substrate 2
JMJD6 jumonji domain containing 6
KRT17 keratin 17, type I
LASP1 LIM and SH3 protein 1
MARCKS myristoylated alanine-rich protein kinase C substrate
MELK maternal embryonic leucine zipper kinase
MGAT2 mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
MRPS30 mitochondrial ribosomal protein S30
NET1 neuroepithelial cell transforming 1
NFIL3 nuclear factor, interleukin 3 regulated
NUP62 nucleoporin 62kDa
PCNA proliferating cell nuclear antigen
PLIN2 perilipin 2
PLK1 polo-like kinase 1
PNP purine nucleoside phosphorylase
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POU2AF1 POU class 2 associating factor 1
RAE1 ribonucleic acid export 1
RANBP2 RAN binding protein 2
S100A6 S100 calcium binding protein A6
S100P S100 calcium binding protein P
SLC38A2 solute carrier family 38, member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SPINK1 serine peptidase inhibitor, Kazal type 1
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFF1 trefoil factor 1
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TOP2A topoisomerase (DNA) II alpha 170kDa
TUBB3 tubulin, beta 3 class III
TXLNA taxilin alpha
UBE2C ubiquitin-conjugating enzyme E2C
UBE3C ubiquitin protein ligase E3C
UGT2B17 UDP glucuronosyltransferase 2 family, polypeptide B17
USP22 ubiquitin specific peptidase 22
VCP valosin containing protein
XBP1 X-box binding protein 1