BRD-K92571446_WZ-3105_HEPG2_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

137 genes differentially expressed following the BRD-K92571446_WZ-3105_HEPG2_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ANXA1 annexin A1
AREG amphiregulin
ATF3 activating transcription factor 3
ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b
CA11 carbonic anhydrase XI
CD36 CD36 molecule (thrombospondin receptor)
CD9 CD9 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CFD complement factor D (adipsin)
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
COL5A2 collagen, type V, alpha 2
CPE carboxypeptidase E
CPM carboxypeptidase M
CTSL cathepsin L
CXCL8 chemokine (C-X-C motif) ligand 8
DUSP6 dual specificity phosphatase 6
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
EGR1 early growth response 1
EMP1 epithelial membrane protein 1
ENC1 ectodermal-neural cortex 1 (with BTB domain)
F11R F11 receptor
FABP4 fatty acid binding protein 4, adipocyte
G0S2 G0/G1 switch 2
GABARAPL1 GABA(A) receptor-associated protein like 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GPNMB glycoprotein (transmembrane) nmb
HIST1H1C histone cluster 1, H1c
HIST2H2BE histone cluster 2, H2be
IER3 immediate early response 3
IFRD1 interferon-related developmental regulator 1
IGFBP5 insulin-like growth factor binding protein 5
IL7R interleukin 7 receptor
INHBA inhibin, beta A
JAG1 jagged 1
JUN jun proto-oncogene
KLF10 Kruppel-like factor 10
KRT5 keratin 5, type II
LGMN legumain
LMO4 LIM domain only 4
LTBP1 latent transforming growth factor beta binding protein 1
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MIR22HG MIR22 host gene
MME membrane metallo-endopeptidase
MMP12 matrix metallopeptidase 12
NEBL nebulette
NELL2 NEL-like 2 (chicken)
NPIPB3 nuclear pore complex interacting protein family, member B3
NPL N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase)
NR4A2 nuclear receptor subfamily 4, group A, member 2
NRGN neurogranin (protein kinase C substrate, RC3)
NTS neurotensin
PLAUR plasminogen activator, urokinase receptor
PLS3 plastin 3
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
PROS1 protein S (alpha)
PRR7 proline rich 7 (synaptic)
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTHLH parathyroid hormone-like hormone
RCAN1 regulator of calcineurin 1
RGCC regulator of cell cycle
RNF11 ring finger protein 11
S100A4 S100 calcium binding protein A4
SCPEP1 serine carboxypeptidase 1
SDC2 syndecan 2
SELENBP1 selenium binding protein 1
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SFN stratifin
SOX4 SRY (sex determining region Y)-box 4
SPP1 secreted phosphoprotein 1
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TFPI2 tissue factor pathway inhibitor 2
TMEM45A transmembrane protein 45A
TRAC T cell receptor alpha constant
TUBA1A tubulin, alpha 1a
TXNIP thioredoxin interacting protein
WIF1 WNT inhibitory factor 1
XIST X inactive specific transcript (non-protein coding)
ZFAND5 zinc finger, AN1-type domain 5

decreased expression

Symbol Name
ABCC6 ATP-binding cassette, sub-family C (CFTR/MRP), member 6
AMDHD2 amidohydrolase domain containing 2
ARMT1 acidic residue methyltransferase 1
ASCC3 activating signal cointegrator 1 complex subunit 3
BEX1 brain expressed, X-linked 1
CCNA2 cyclin A2
CDC6 cell division cycle 6
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
ERBB2 erb-b2 receptor tyrosine kinase 2
ERBB3 erb-b2 receptor tyrosine kinase 3
GALE UDP-galactose-4-epimerase
GOLGA8A golgin A8 family, member A
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HNMT histamine N-methyltransferase
IFI44L interferon-induced protein 44-like
IGLJ3 immunoglobulin lambda joining 3
IGLV2-23 immunoglobulin lambda variable 2-23
IL17RB interleukin 17 receptor B
JCHAIN joining chain of multimeric IgA and IgM
LOC100505650 uncharacterized LOC100505650
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MARCKS myristoylated alanine-rich protein kinase C substrate
MCAM melanoma cell adhesion molecule
MCM3 minichromosome maintenance complex component 3
MGAT2 mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
MRPL12 mitochondrial ribosomal protein L12
MSLN mesothelin
NUP43 nucleoporin 43kDa
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
OXTR oxytocin receptor
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta
PLAC8 placenta-specific 8
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POU2AF1 POU class 2 associating factor 1
PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2)
PROM1 prominin 1
PSMG1 proteasome (prosome, macropain) assembly chaperone 1
QPRT quinolinate phosphoribosyltransferase
RMI1 RecQ mediated genome instability 1
RRAS2 related RAS viral (r-ras) oncogene homolog 2
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SOX11 SRY (sex determining region Y)-box 11
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
SWAP70 SWAP switching B-cell complex 70kDa subunit
TBL2 transducin (beta)-like 2
TBP TATA box binding protein
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TMEM97 transmembrane protein 97
TOP2A topoisomerase (DNA) II alpha 170kDa
TSPYL5 TSPY-like 5
UGT2B28 UDP glucuronosyltransferase 2 family, polypeptide B28
XBP1 X-box binding protein 1