BRD-K92571446_WZ-3105_HCC515_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

215 genes differentially expressed following the BRD-K92571446_WZ-3105_HCC515_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ACKR3 atypical chemokine receptor 3
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ALB albumin
ALCAM activated leukocyte cell adhesion molecule
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ANGPTL2 angiopoietin-like 2
ANKRD36B ankyrin repeat domain 36B
AP3S1 adaptor-related protein complex 3, sigma 1 subunit
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
APLP2 amyloid beta (A4) precursor-like protein 2
APOD apolipoprotein D
AQP1 aquaporin 1 (Colton blood group)
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1
ASPN asporin
ATF3 activating transcription factor 3
ATP6AP1 ATPase, H+ transporting, lysosomal accessory protein 1
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
C6ORF62 chromosome 6 open reading frame 62
C9ORF16 chromosome 9 open reading frame 16
CADM1 cell adhesion molecule 1
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CAPG capping protein (actin filament), gelsolin-like
CCL19 chemokine (C-C motif) ligand 19
CCL20 chemokine (C-C motif) ligand 20
CCL5 chemokine (C-C motif) ligand 5
CD44 CD44 molecule (Indian blood group)
CD48 CD48 molecule
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CES1 carboxylesterase 1
CFB complement factor B
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
CLU clusterin
COL18A1 collagen, type XVIII, alpha 1
CPB1 carboxypeptidase B1 (tissue)
CPE carboxypeptidase E
CRABP2 cellular retinoic acid binding protein 2
CRTAP cartilage associated protein
CST3 cystatin C
CTGF connective tissue growth factor
CTSB cathepsin B
CTSS cathepsin S
CXCL10 chemokine (C-X-C motif) ligand 10
CYBB cytochrome b-245, beta polypeptide
CYR61 cysteine-rich, angiogenic inducer, 61
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
EGR1 early growth response 1
EIF5A eukaryotic translation initiation factor 5A
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
ESR1 estrogen receptor 1
FHL1 four and a half LIM domains 1
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
GADD45B growth arrest and DNA-damage-inducible, beta
GLUL glutamate-ammonia ligase
GOLGA8A golgin A8 family, member A
GOLGA8B golgin A8 family, member B
GPNMB glycoprotein (transmembrane) nmb
GPR137B G protein-coupled receptor 137B
GPX3 glutathione peroxidase 3
GRB14 growth factor receptor-bound protein 14
GUCY1B3 guanylate cyclase 1, soluble, beta 3
HACD3 3-hydroxyacyl-CoA dehydratase 3
HES1 hes family bHLH transcription factor 1
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HIP1 huntingtin interacting protein 1
HIST1H1C histone cluster 1, H1c
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
ICAM1 intercellular adhesion molecule 1
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IDS iduronate 2-sulfatase
IFI30 interferon, gamma-inducible protein 30
IFI6 interferon, alpha-inducible protein 6
IFITM1 interferon induced transmembrane protein 1
IGF1 insulin-like growth factor 1 (somatomedin C)
IGFBP3 insulin-like growth factor binding protein 3
IGFBP7 insulin-like growth factor binding protein 7
IL13RA1 interleukin 13 receptor, alpha 1
IL7R interleukin 7 receptor
ISG15 ISG15 ubiquitin-like modifier
KLHL24 kelch-like family member 24
LAMP1 lysosomal-associated membrane protein 1
LAMP2 lysosomal-associated membrane protein 2
LAMP3 lysosomal-associated membrane protein 3
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAN1A1 mannosidase, alpha, class 1A, member 1
MAN2B1 mannosidase, alpha, class 2B, member 1
MAN2B2 mannosidase, alpha, class 2B, member 2
MEIS1 Meis homeobox 1
MEIS2 Meis homeobox 2
MFAP2 microfibrillar-associated protein 2
MFAP5 microfibrillar associated protein 5
MME membrane metallo-endopeptidase
MMP9 matrix metallopeptidase 9
MXRA5 matrix-remodelling associated 5
MXRA7 matrix-remodelling associated 7
NPC2 Niemann-Pick disease, type C2
PCP4 Purkinje cell protein 4
PFN2 profilin 2
PLD3 phospholipase D family, member 3
PLTP phospholipid transfer protein
PROS1 protein S (alpha)
PSAP prosaposin
RBP1 retinol binding protein 1, cellular
RGS5 regulator of G-protein signaling 5
RHOQ ras homolog family member Q
RIOK3 RIO kinase 3
RSRP1 arginine/serine-rich protein 1
SAT1 spermidine/spermine N1-acetyltransferase 1
SCARB2 scavenger receptor class B, member 2
SCPEP1 serine carboxypeptidase 1
SDC2 syndecan 2
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SEPP1 selenoprotein P, plasma, 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SFTPC surfactant protein C
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SOD2 superoxide dismutase 2, mitochondrial
SOX4 SRY (sex determining region Y)-box 4
SPARCL1 SPARC-like 1 (hevin)
SPON2 spondin 2, extracellular matrix protein
STC1 stanniocalcin 1
SULF1 sulfatase 1
TCF4 transcription factor 4
THY1 Thy-1 cell surface antigen
TIMP3 TIMP metallopeptidase inhibitor 3
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMSB15A thymosin beta 15a
TPP1 tripeptidyl peptidase I
TRA2A transformer 2 alpha homolog (Drosophila)
TSPAN7 tetraspanin 7
TUSC3 tumor suppressor candidate 3
TYROBP TYRO protein tyrosine kinase binding protein
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
VDAC1 voltage-dependent anion channel 1
VEGFA vascular endothelial growth factor A
WASF3 WAS protein family, member 3
WIF1 WNT inhibitory factor 1
XIST X inactive specific transcript (non-protein coding)
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
AGR2 anterior gradient 2
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
AURKA aurora kinase A
CANT1 calcium activated nucleotidase 1
CAST calpastatin
CCNA2 cyclin A2
CDC20 cell division cycle 20
CDC42EP4 CDC42 effector protein (Rho GTPase binding) 4
CDCA4 cell division cycle associated 4
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta
CLTC clathrin, heavy chain (Hc)
CSE1L CSE1 chromosome segregation 1-like (yeast)
CSTF1 cleavage stimulation factor, 3' pre-RNA, subunit 1, 50kDa
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
EAPP E2F-associated phosphoprotein
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
FCGBP Fc fragment of IgG binding protein
G3BP2 GTPase activating protein (SH3 domain) binding protein 2
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
H2AFX H2A histone family, member X
HMGB2 high mobility group box 2
HOXB7 homeobox B7
HSPA8 heat shock 70kDa protein 8
IGFBP4 insulin-like growth factor binding protein 4
IMP3 IMP3, U3 small nucleolar ribonucleoprotein
IRS2 insulin receptor substrate 2
IVNS1ABP influenza virus NS1A binding protein
JADE2 jade family PHD finger 2
KDM5D lysine (K)-specific demethylase 5D
KRT15 keratin 15, type I
KRT18 keratin 18, type I
KRT19 keratin 19, type I
KRT7 keratin 7, type II
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MED1 mediator complex subunit 1
MRPL12 mitochondrial ribosomal protein L12
MYBPC1 myosin binding protein C, slow type
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NMI N-myc (and STAT) interactor
NOL11 nucleolar protein 11
NOP56 NOP56 ribonucleoprotein
NR2F2 nuclear receptor subfamily 2, group F, member 2
PCNA proliferating cell nuclear antigen
PDE4B phosphodiesterase 4B, cAMP-specific
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
PRC1 protein regulator of cytokinesis 1
PTPRK protein tyrosine phosphatase, receptor type, K
PUF60 poly-U binding splicing factor 60KDa
RAE1 ribonucleic acid export 1
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RGS2 regulator of G-protein signaling 2
RPS4Y1 ribosomal protein S4, Y-linked 1
S100P S100 calcium binding protein P
SLC38A2 solute carrier family 38, member 2
SPINK1 serine peptidase inhibitor, Kazal type 1
SRGN serglycin
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFF1 trefoil factor 1
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TMEM97 transmembrane protein 97
TOP2A topoisomerase (DNA) II alpha 170kDa
TRAPPC3 trafficking protein particle complex 3
TRIP6 thyroid hormone receptor interactor 6
TSPAN8 tetraspanin 8
TYMS thymidylate synthetase
USP1 ubiquitin specific peptidase 1
XBP1 X-box binding protein 1