BRD-K92571446_WZ-3105_HCC515_24_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

254 genes differentially expressed following the BRD-K92571446_WZ-3105_HCC515_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ADD3 adducin 3 (gamma)
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ALB albumin
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ANGPTL2 angiopoietin-like 2
AP3S1 adaptor-related protein complex 3, sigma 1 subunit
APLP2 amyloid beta (A4) precursor-like protein 2
APOD apolipoprotein D
AQP1 aquaporin 1 (Colton blood group)
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1
ASPN asporin
ATF3 activating transcription factor 3
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
BGN biglycan
C2 complement component 2
C4BPA complement component 4 binding protein, alpha
C6ORF62 chromosome 6 open reading frame 62
C9ORF16 chromosome 9 open reading frame 16
CADM1 cell adhesion molecule 1
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
CD44 CD44 molecule (Indian blood group)
CD9 CD9 molecule
CDC42 cell division cycle 42
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CES1 carboxylesterase 1
CFB complement factor B
CFI complement factor I
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
CLU clusterin
COL18A1 collagen, type XVIII, alpha 1
COL3A1 collagen, type III, alpha 1
COL6A2 collagen, type VI, alpha 2
COLEC11 collectin sub-family member 11
CPE carboxypeptidase E
CRABP2 cellular retinoic acid binding protein 2
CRTAP cartilage associated protein
CSRP2 cysteine and glycine-rich protein 2
CTGF connective tissue growth factor
CTSB cathepsin B
CTSS cathepsin S
CXCL2 chemokine (C-X-C motif) ligand 2
CYBB cytochrome b-245, beta polypeptide
CYR61 cysteine-rich, angiogenic inducer, 61
DUSP1 dual specificity phosphatase 1
ECM1 extracellular matrix protein 1
EGR1 early growth response 1
EIF5A eukaryotic translation initiation factor 5A
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EPB41L4B erythrocyte membrane protein band 4.1 like 4B
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FABP4 fatty acid binding protein 4, adipocyte
FHL1 four and a half LIM domains 1
FMO2 flavin containing monooxygenase 2 (non-functional)
FOS FBJ murine osteosarcoma viral oncogene homolog
GAA glucosidase, alpha; acid
GADD45B growth arrest and DNA-damage-inducible, beta
GAP43 growth associated protein 43
GATAD1 GATA zinc finger domain containing 1
GLUL glutamate-ammonia ligase
GM2A GM2 ganglioside activator
GNAS GNAS complex locus
GOLGA8A golgin A8 family, member A
GOLGA8B golgin A8 family, member B
GPNMB glycoprotein (transmembrane) nmb
GPX3 glutathione peroxidase 3
GRB14 growth factor receptor-bound protein 14
GSN gelsolin
GUSB glucuronidase, beta
GUSBP3 glucuronidase, beta pseudogene 3
HES1 hes family bHLH transcription factor 1
HIP1 huntingtin interacting protein 1
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2AE histone cluster 1, H2ae
HIST1H2BD histone cluster 1, H2bd
HIST1H2BG histone cluster 1, H2bg
HIST1H2BH histone cluster 1, H2bh
HIST2H2BE histone cluster 2, H2be
ICAM1 intercellular adhesion molecule 1
IDS iduronate 2-sulfatase
IFI30 interferon, gamma-inducible protein 30
IFI6 interferon, alpha-inducible protein 6
IFITM1 interferon induced transmembrane protein 1
IGFBP7 insulin-like growth factor binding protein 7
KCNQ1 potassium channel, voltage gated KQT-like subfamily Q, member 1
LAMP1 lysosomal-associated membrane protein 1
LAMP2 lysosomal-associated membrane protein 2
LAMP3 lysosomal-associated membrane protein 3
LGALS3 lectin, galactoside-binding, soluble, 3
LOC100272216 uncharacterized LOC100272216
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MEIS1 Meis homeobox 1
MFAP2 microfibrillar-associated protein 2
MME membrane metallo-endopeptidase
MMP9 matrix metallopeptidase 9
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1X metallothionein 1X
MXRA7 matrix-remodelling associated 7
NACA nascent polypeptide-associated complex alpha subunit
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NPC2 Niemann-Pick disease, type C2
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5
PDIA5 protein disulfide isomerase family A, member 5
PECAM1 platelet/endothelial cell adhesion molecule 1
PFN2 profilin 2
PHKB phosphorylase kinase, beta
PIGT phosphatidylinositol glycan anchor biosynthesis, class T
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PLTP phospholipid transfer protein
PROS1 protein S (alpha)
PRSS21 protease, serine, 21 (testisin)
PTN pleiotrophin
RBP1 retinol binding protein 1, cellular
REL v-rel avian reticuloendotheliosis viral oncogene homolog
RGS5 regulator of G-protein signaling 5
RNF130 ring finger protein 130
RRAGD Ras-related GTP binding D
RSRP1 arginine/serine-rich protein 1
SAT1 spermidine/spermine N1-acetyltransferase 1
SCARB2 scavenger receptor class B, member 2
SCPEP1 serine carboxypeptidase 1
SDC2 syndecan 2
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SEPP1 selenoprotein P, plasma, 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SFTPC surfactant protein C
SH3BGRL SH3 domain binding glutamate-rich protein like
SHANK2 SH3 and multiple ankyrin repeat domains 2
SLC47A1 solute carrier family 47 (multidrug and toxin extrusion), member 1
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
SOD2 superoxide dismutase 2, mitochondrial
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPARCL1 SPARC-like 1 (hevin)
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
SPON2 spondin 2, extracellular matrix protein
STC1 stanniocalcin 1
TAGLN transgelin
TCF4 transcription factor 4
TGFB1 transforming growth factor, beta 1
THY1 Thy-1 cell surface antigen
TIMP3 TIMP metallopeptidase inhibitor 3
TMEM176B transmembrane protein 176B
TMSB15A thymosin beta 15a
TPP1 tripeptidyl peptidase I
TRA2A transformer 2 alpha homolog (Drosophila)
TSC22D3 TSC22 domain family, member 3
TSPAN7 tetraspanin 7
TUSC3 tumor suppressor candidate 3
TYROBP TYRO protein tyrosine kinase binding protein
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
VDAC1 voltage-dependent anion channel 1
VEGFA vascular endothelial growth factor A
WIF1 WNT inhibitory factor 1
XIST X inactive specific transcript (non-protein coding)
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ADAM10 ADAM metallopeptidase domain 10
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide
AP2B1 adaptor-related protein complex 2, beta 1 subunit
ASF1A anti-silencing function 1A histone chaperone
ATMIN ATM interactor
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
AURKA aurora kinase A
BCLAF1 BCL2-associated transcription factor 1
CCNA2 cyclin A2
CCNB2 cyclin B2
CDC20 cell division cycle 20
CDC42EP4 CDC42 effector protein (Rho GTPase binding) 4
CDCA4 cell division cycle associated 4
CDK1 cyclin-dependent kinase 1
CDK7 cyclin-dependent kinase 7
CENPF centromere protein F, 350/400kDa
CLTC clathrin, heavy chain (Hc)
CSE1L CSE1 chromosome segregation 1-like (yeast)
CSTF1 cleavage stimulation factor, 3' pre-RNA, subunit 1, 50kDa
DAPK1 death-associated protein kinase 1
DCK deoxycytidine kinase
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EAPP E2F-associated phosphoprotein
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
G3BP2 GTPase activating protein (SH3 domain) binding protein 2
GALNT7 polypeptide N-acetylgalactosaminyltransferase 7
GAR1 GAR1 ribonucleoprotein
GLRX glutaredoxin (thioltransferase)
GRSF1 G-rich RNA sequence binding factor 1
H2AFX H2A histone family, member X
HMGB2 high mobility group box 2
HSPA1A heat shock 70kDa protein 1A
HSPA8 heat shock 70kDa protein 8
HSPD1 heat shock 60kDa protein 1 (chaperonin)
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial
IGFBP4 insulin-like growth factor binding protein 4
IMP3 IMP3, U3 small nucleolar ribonucleoprotein
IVNS1ABP influenza virus NS1A binding protein
KDM5D lysine (K)-specific demethylase 5D
KRT15 keratin 15, type I
KRT18 keratin 18, type I
LBR lamin B receptor
LMNB1 lamin B1
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LTF lactotransferrin
MACF1 microtubule-actin crosslinking factor 1
MARCKS myristoylated alanine-rich protein kinase C substrate
MED1 mediator complex subunit 1
MKI67 marker of proliferation Ki-67
MRPL12 mitochondrial ribosomal protein L12
MRPL17 mitochondrial ribosomal protein L17
MRPS2 mitochondrial ribosomal protein S2
MSMB microseminoprotein, beta-
MYBPC1 myosin binding protein C, slow type
NAV3 neuron navigator 3
NCL nucleolin
NMI N-myc (and STAT) interactor
NOL11 nucleolar protein 11
NUP54 nucleoporin 54kDa
PBK PDZ binding kinase
PCNA proliferating cell nuclear antigen
PDE4B phosphodiesterase 4B, cAMP-specific
PFDN4 prefoldin subunit 4
PLAC8 placenta-specific 8
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
PSMD12 proteasome (prosome, macropain) 26S subunit, non-ATPase, 12
RAD23B RAD23 homolog B (S. cerevisiae)
RAE1 ribonucleic acid export 1
RGS2 regulator of G-protein signaling 2
RPS4Y1 ribosomal protein S4, Y-linked 1
S100P S100 calcium binding protein P
SLC38A2 solute carrier family 38, member 2
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFF1 trefoil factor 1
TMEM97 transmembrane protein 97
TNPO1 transportin 1
TOP2A topoisomerase (DNA) II alpha 170kDa
TRAPPC3 trafficking protein particle complex 3
TUBB4B tubulin, beta 4B class IVb
TYMS thymidylate synthetase
UBE2I ubiquitin-conjugating enzyme E2I
UQCRFS1 ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1
USP1 ubiquitin specific peptidase 1
USP7 ubiquitin specific peptidase 7 (herpes virus-associated)
VCP valosin containing protein
XBP1 X-box binding protein 1