BRD-K92571446_WZ-3105_HCC515_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

218 genes differentially expressed following the BRD-K92571446_WZ-3105_HCC515_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ACKR3 atypical chemokine receptor 3
ADD3 adducin 3 (gamma)
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ALB albumin
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ANGPTL2 angiopoietin-like 2
ANPEP alanyl (membrane) aminopeptidase
AP3S1 adaptor-related protein complex 3, sigma 1 subunit
APLP2 amyloid beta (A4) precursor-like protein 2
APOC2 apolipoprotein C-II
AQP1 aquaporin 1 (Colton blood group)
AQP9 aquaporin 9
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1
ASPN asporin
ATF3 activating transcription factor 3
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
C2 complement component 2
C6ORF48 chromosome 6 open reading frame 48
C6ORF62 chromosome 6 open reading frame 62
C9ORF16 chromosome 9 open reading frame 16
CADM1 cell adhesion molecule 1
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
CCL20 chemokine (C-C motif) ligand 20
CD44 CD44 molecule (Indian blood group)
CD9 CD9 molecule
CES1 carboxylesterase 1
CFB complement factor B
CH25H cholesterol 25-hydroxylase
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLU clusterin
COL18A1 collagen, type XVIII, alpha 1
COL3A1 collagen, type III, alpha 1
COL5A2 collagen, type V, alpha 2
COL6A1 collagen, type VI, alpha 1
COL6A2 collagen, type VI, alpha 2
CPB1 carboxypeptidase B1 (tissue)
CPE carboxypeptidase E
CRTAP cartilage associated protein
CSRP2 cysteine and glycine-rich protein 2
CSTA cystatin A (stefin A)
CTGF connective tissue growth factor
CTSB cathepsin B
CTSS cathepsin S
CXCL8 chemokine (C-X-C motif) ligand 8
CYR61 cysteine-rich, angiogenic inducer, 61
DST dystonin
E2F2 E2F transcription factor 2
ECM1 extracellular matrix protein 1
EGR1 early growth response 1
EIF5A eukaryotic translation initiation factor 5A
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FBP1 fructose-1,6-bisphosphatase 1
FGF13 fibroblast growth factor 13
FHL1 four and a half LIM domains 1
FN1 fibronectin 1
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GEM GTP binding protein overexpressed in skeletal muscle
GLUL glutamate-ammonia ligase
GM2A GM2 ganglioside activator
GPNMB glycoprotein (transmembrane) nmb
GPR137B G protein-coupled receptor 137B
GPX3 glutathione peroxidase 3
GRB14 growth factor receptor-bound protein 14
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
GUCY1B3 guanylate cyclase 1, soluble, beta 3
HACD3 3-hydroxyacyl-CoA dehydratase 3
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HIST1H1C histone cluster 1, H1c
HIST1H2BC histone cluster 1, H2bc
HIST1H2BG histone cluster 1, H2bg
HIST1H3H histone cluster 1, H3h
HIST2H2BE histone cluster 2, H2be
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IDS iduronate 2-sulfatase
IFI30 interferon, gamma-inducible protein 30
IFI6 interferon, alpha-inducible protein 6
IFITM1 interferon induced transmembrane protein 1
IGFBP7 insulin-like growth factor binding protein 7
IL1R1 interleukin 1 receptor, type I
IL6 interleukin 6
IL7R interleukin 7 receptor
JAM2 junctional adhesion molecule 2
KLHL24 kelch-like family member 24
LAMP1 lysosomal-associated membrane protein 1
LAMP3 lysosomal-associated membrane protein 3
LGALS3 lectin, galactoside-binding, soluble, 3
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAN1A1 mannosidase, alpha, class 1A, member 1
MAN1C1 mannosidase, alpha, class 1C, member 1
MAN2B2 mannosidase, alpha, class 2B, member 2
MDK midkine (neurite growth-promoting factor 2)
MEIS2 Meis homeobox 2
METRN meteorin, glial cell differentiation regulator
MFAP2 microfibrillar-associated protein 2
MME membrane metallo-endopeptidase
MMP9 matrix metallopeptidase 9
MXRA7 matrix-remodelling associated 7
NEBL nebulette
NR4A1 nuclear receptor subfamily 4, group A, member 1
NTS neurotensin
OPTN optineurin
PAM peptidylglycine alpha-amidating monooxygenase
PCBP2 poly(rC) binding protein 2
PCP4 Purkinje cell protein 4
PDE1A phosphodiesterase 1A, calmodulin-dependent
PDK4 pyruvate dehydrogenase kinase, isozyme 4
PDP1 pyruvate dehyrogenase phosphatase catalytic subunit 1
PECAM1 platelet/endothelial cell adhesion molecule 1
PFN2 profilin 2
PLD3 phospholipase D family, member 3
PLTP phospholipid transfer protein
PROS1 protein S (alpha)
PSAP prosaposin
RBP1 retinol binding protein 1, cellular
RCBTB1 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1
REL v-rel avian reticuloendotheliosis viral oncogene homolog
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGS5 regulator of G-protein signaling 5
RHOQ ras homolog family member Q
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
RRAGD Ras-related GTP binding D
RSRP1 arginine/serine-rich protein 1
SAT1 spermidine/spermine N1-acetyltransferase 1
SCPEP1 serine carboxypeptidase 1
SDC2 syndecan 2
SEPP1 selenoprotein P, plasma, 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SFRP1 secreted frizzled-related protein 1
SFTPC surfactant protein C
SH2D1A SH2 domain containing 1A
SOX4 SRY (sex determining region Y)-box 4
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPARCL1 SPARC-like 1 (hevin)
SPON2 spondin 2, extracellular matrix protein
STC1 stanniocalcin 1
TCF4 transcription factor 4
THY1 Thy-1 cell surface antigen
TIMP3 TIMP metallopeptidase inhibitor 3
TRA2A transformer 2 alpha homolog (Drosophila)
TSPAN7 tetraspanin 7
TTC3 tetratricopeptide repeat domain 3
TUSC3 tumor suppressor candidate 3
TWIST1 twist family bHLH transcription factor 1
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
VDAC1 voltage-dependent anion channel 1
VEGFA vascular endothelial growth factor A
WASF3 WAS protein family, member 3
WIF1 WNT inhibitory factor 1
XIST X inactive specific transcript (non-protein coding)
ZNF331 zinc finger protein 331
ZNF91 zinc finger protein 91
ZSCAN18 zinc finger and SCAN domain containing 18

decreased expression

Symbol Name
ABCE1 ATP-binding cassette, sub-family E (OABP), member 1
ADGRG6 adhesion G protein-coupled receptor G6
AFF1 AF4/FMR2 family, member 1
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
AURKA aurora kinase A
C1ORF116 chromosome 1 open reading frame 116
CAB39 calcium binding protein 39
CANT1 calcium activated nucleotidase 1
CASP7 caspase 7, apoptosis-related cysteine peptidase
CCNA2 cyclin A2
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta
CLTC clathrin, heavy chain (Hc)
CSTF1 cleavage stimulation factor, 3' pre-RNA, subunit 1, 50kDa
EAPP E2F-associated phosphoprotein
G3BP2 GTPase activating protein (SH3 domain) binding protein 2
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class)
H2AFX H2A histone family, member X
HMGB2 high mobility group box 2
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPA8 heat shock 70kDa protein 8
IMP3 IMP3, U3 small nucleolar ribonucleoprotein
IRS2 insulin receptor substrate 2
IVNS1ABP influenza virus NS1A binding protein
KIF14 kinesin family member 14
KRT15 keratin 15, type I
LBR lamin B receptor
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MED1 mediator complex subunit 1
MKI67 marker of proliferation Ki-67
MRPL12 mitochondrial ribosomal protein L12
NMI N-myc (and STAT) interactor
NOC3L nucleolar complex associated 3 homolog (S. cerevisiae)
NOL11 nucleolar protein 11
PCNA proliferating cell nuclear antigen
PDE4B phosphodiesterase 4B, cAMP-specific
PLAC8 placenta-specific 8
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
PRC1 protein regulator of cytokinesis 1
PSMD12 proteasome (prosome, macropain) 26S subunit, non-ATPase, 12
PUF60 poly-U binding splicing factor 60KDa
RAB4A RAB4A, member RAS oncogene family
RCHY1 ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase
RGS2 regulator of G-protein signaling 2
SMC4 structural maintenance of chromosomes 4
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TMEM97 transmembrane protein 97
TOMM70A translocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae)
TOP2A topoisomerase (DNA) II alpha 170kDa
TYMS thymidylate synthetase
USO1 USO1 vesicle transport factor
USP1 ubiquitin specific peptidase 1
USP7 ubiquitin specific peptidase 7 (herpes virus-associated)
XBP1 X-box binding protein 1