BRD-K92571446_WZ-3105_HCC515_24_h_0.37_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

245 genes differentially expressed following the BRD-K92571446_WZ-3105_HCC515_24_h_0.37_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AAK1 AP2 associated kinase 1
ACKR3 atypical chemokine receptor 3
ADIRF adipogenesis regulatory factor
ADM adrenomedullin
ALB albumin
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ANPEP alanyl (membrane) aminopeptidase
AP3S1 adaptor-related protein complex 3, sigma 1 subunit
APLP2 amyloid beta (A4) precursor-like protein 2
APOD apolipoprotein D
AQP1 aquaporin 1 (Colton blood group)
AQP9 aquaporin 9
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1
ASPN asporin
ATF3 activating transcription factor 3
ATP6AP1 ATPase, H+ transporting, lysosomal accessory protein 1
ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b
ATP6V0E2 ATPase, H+ transporting V0 subunit e2
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
BCL6 B-cell CLL/lymphoma 6
BSCL2 Berardinelli-Seip congenital lipodystrophy 2 (seipin)
BSG basigin (Ok blood group)
C1ORF54 chromosome 1 open reading frame 54
C6ORF48 chromosome 6 open reading frame 48
C6ORF62 chromosome 6 open reading frame 62
CAPG capping protein (actin filament), gelsolin-like
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
CCL20 chemokine (C-C motif) ligand 20
CD44 CD44 molecule (Indian blood group)
CD93 CD93 molecule
CDC42 cell division cycle 42
CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CES1 carboxylesterase 1
CFD complement factor D (adipsin)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLDN5 claudin 5
CLU clusterin
COL6A2 collagen, type VI, alpha 2
COL6A3 collagen, type VI, alpha 3
CPE carboxypeptidase E
CRTAP cartilage associated protein
CSRP2 cysteine and glycine-rich protein 2
CST3 cystatin C
CSTA cystatin A (stefin A)
CTGF connective tissue growth factor
CTSB cathepsin B
CTSL cathepsin L
CXCL8 chemokine (C-X-C motif) ligand 8
CYBA cytochrome b-245, alpha polypeptide
CYBB cytochrome b-245, beta polypeptide
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
CYR61 cysteine-rich, angiogenic inducer, 61
E2F2 E2F transcription factor 2
EGR1 early growth response 1
EIF5A eukaryotic translation initiation factor 5A
EMP3 epithelial membrane protein 3
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EPAS1 endothelial PAS domain protein 1
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
EZR ezrin
FABP4 fatty acid binding protein 4, adipocyte
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
FGF13 fibroblast growth factor 13
FN1 fibronectin 1
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
G0S2 G0/G1 switch 2
GADD45A growth arrest and DNA-damage-inducible, alpha
GLUL glutamate-ammonia ligase
GOLGA8A golgin A8 family, member A
GOLGA8B golgin A8 family, member B
GPNMB glycoprotein (transmembrane) nmb
GPR137B G protein-coupled receptor 137B
GPX3 glutathione peroxidase 3
GRB14 growth factor receptor-bound protein 14
GREB1 growth regulation by estrogen in breast cancer 1
GREM1 gremlin 1, DAN family BMP antagonist
GRN granulin
GSN gelsolin
GUCY1B3 guanylate cyclase 1, soluble, beta 3
HACD3 3-hydroxyacyl-CoA dehydratase 3
HBEGF heparin-binding EGF-like growth factor
HCK HCK proto-oncogene, Src family tyrosine kinase
HEXB hexosaminidase B (beta polypeptide)
HIST1H1C histone cluster 1, H1c
HIST1H2AE histone cluster 1, H2ae
HIST1H2BC histone cluster 1, H2bc
HIST1H2BG histone cluster 1, H2bg
HIST2H2BE histone cluster 2, H2be
HNRNPL heterogeneous nuclear ribonucleoprotein L
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IDS iduronate 2-sulfatase
IFI30 interferon, gamma-inducible protein 30
IFI6 interferon, alpha-inducible protein 6
IFITM1 interferon induced transmembrane protein 1
IGFBP3 insulin-like growth factor binding protein 3
IGFBP7 insulin-like growth factor binding protein 7
JAG1 jagged 1
KLHL24 kelch-like family member 24
LAMP1 lysosomal-associated membrane protein 1
LAMP2 lysosomal-associated membrane protein 2
LCN2 lipocalin 2
LGALS1 lectin, galactoside-binding, soluble, 1
LGALS3 lectin, galactoside-binding, soluble, 3
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAP2K3 mitogen-activated protein kinase kinase 3
MEIS2 Meis homeobox 2
METRN meteorin, glial cell differentiation regulator
MFAP5 microfibrillar associated protein 5
MICB MHC class I polypeptide-related sequence B
MIR22HG MIR22 host gene
MME membrane metallo-endopeptidase
MMP9 matrix metallopeptidase 9
MXRA7 matrix-remodelling associated 7
NKG7 natural killer cell granule protein 7
NPC2 Niemann-Pick disease, type C2
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
PAM peptidylglycine alpha-amidating monooxygenase
PCBP2 poly(rC) binding protein 2
PCDH9 protocadherin 9
PCOLCE2 procollagen C-endopeptidase enhancer 2
PDE2A phosphodiesterase 2A, cGMP-stimulated
PDE8B phosphodiesterase 8B
PECAM1 platelet/endothelial cell adhesion molecule 1
PFN2 profilin 2
PHACTR1 phosphatase and actin regulator 1
PI3 peptidase inhibitor 3, skin-derived
PLA1A phospholipase A1 member A
PLAU plasminogen activator, urokinase
PLTP phospholipid transfer protein
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPAP2B phosphatidic acid phosphatase type 2B
PRCP prolylcarboxypeptidase (angiotensinase C)
PRNP prion protein
PROS1 protein S (alpha)
PRR7 proline rich 7 (synaptic)
PSAP prosaposin
RBP4 retinol binding protein 4, plasma
REEP5 receptor accessory protein 5
REG1A regenerating islet-derived 1 alpha
RGS5 regulator of G-protein signaling 5
RHOQ ras homolog family member Q
RNF11 ring finger protein 11
RRAGD Ras-related GTP binding D
RSRP1 arginine/serine-rich protein 1
SAT1 spermidine/spermine N1-acetyltransferase 1
SCPEP1 serine carboxypeptidase 1
SDCBP syndecan binding protein (syntenin)
SEPP1 selenoprotein P, plasma, 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SFN stratifin
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
SOD2 superoxide dismutase 2, mitochondrial
SOX4 SRY (sex determining region Y)-box 4
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPARCL1 SPARC-like 1 (hevin)
SPON2 spondin 2, extracellular matrix protein
SRSF6 serine/arginine-rich splicing factor 6
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma)
STC1 stanniocalcin 1
STC2 stanniocalcin 2
STEAP1 six transmembrane epithelial antigen of the prostate 1
TAPBP TAP binding protein (tapasin)
TCF4 transcription factor 4
TGFB1 transforming growth factor, beta 1
THY1 Thy-1 cell surface antigen
TIMP3 TIMP metallopeptidase inhibitor 3
TMBIM6 transmembrane BAX inhibitor motif containing 6
TMEM14B transmembrane protein 14B
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TRA2A transformer 2 alpha homolog (Drosophila)
TRD T cell receptor delta locus
TSC22D3 TSC22 domain family, member 3
TSPAN7 tetraspanin 7
TUBB2A tubulin, beta 2A class IIa
TUSC3 tumor suppressor candidate 3
TWIST1 twist family bHLH transcription factor 1
TYROBP TYRO protein tyrosine kinase binding protein
UBE2C ubiquitin-conjugating enzyme E2C
VDAC1 voltage-dependent anion channel 1
VEGFA vascular endothelial growth factor A
WASF3 WAS protein family, member 3
WIF1 WNT inhibitory factor 1
XIST X inactive specific transcript (non-protein coding)
ZFP36 ZFP36 ring finger protein
ZNF331 zinc finger protein 331
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ARFIP1 ADP-ribosylation factor interacting protein 1
ARFIP2 ADP-ribosylation factor interacting protein 2
ASF1A anti-silencing function 1A histone chaperone
ATF1 activating transcription factor 1
AURKA aurora kinase A
CASP8AP2 caspase 8 associated protein 2
CCNA2 cyclin A2
EAPP E2F-associated phosphoprotein
GALNT7 polypeptide N-acetylgalactosaminyltransferase 7
GRSF1 G-rich RNA sequence binding factor 1
GSPT2 G1 to S phase transition 2
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPA8 heat shock 70kDa protein 8
IFI44L interferon-induced protein 44-like
IGFBP4 insulin-like growth factor binding protein 4
IGL immunoglobulin lambda locus
JADE2 jade family PHD finger 2
KRT7 keratin 7, type II
LRBA LPS-responsive vesicle trafficking, beach and anchor containing
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MELK maternal embryonic leucine zipper kinase
MRPL12 mitochondrial ribosomal protein L12
MYLK myosin light chain kinase
NIF3L1 NIF3 NGG1 interacting factor 3-like 1 (S. cerevisiae)
NLRP2 NLR family, pyrin domain containing 2
NMI N-myc (and STAT) interactor
NOC3L nucleolar complex associated 3 homolog (S. cerevisiae)
NOL11 nucleolar protein 11
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1
PCNA proliferating cell nuclear antigen
PHIP pleckstrin homology domain interacting protein
PLAC8 placenta-specific 8
POP4 processing of precursor 4, ribonuclease P/MRP subunit (S. cerevisiae)
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
PSMD12 proteasome (prosome, macropain) 26S subunit, non-ATPase, 12
PSMG1 proteasome (prosome, macropain) assembly chaperone 1
RAB4A RAB4A, member RAS oncogene family
RFC2 replication factor C (activator 1) 2, 40kDa
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13
SPINK1 serine peptidase inhibitor, Kazal type 1
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TMEM97 transmembrane protein 97
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TOMM70A translocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae)
TOP2A topoisomerase (DNA) II alpha 170kDa
TRAPPC3 trafficking protein particle complex 3
UMPS uridine monophosphate synthetase
USO1 USO1 vesicle transport factor
XBP1 X-box binding protein 1