BRD-K92571446_WZ-3105_HA1E_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

216 genes differentially expressed following the BRD-K92571446_WZ-3105_HA1E_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ACKR3 atypical chemokine receptor 3
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADIRF adipogenesis regulatory factor
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ANGPTL2 angiopoietin-like 2
APOC2 apolipoprotein C-II
AQP1 aquaporin 1 (Colton blood group)
AREG amphiregulin
ARHGAP32 Rho GTPase activating protein 32
ARL4C ADP-ribosylation factor-like 4C
ASPN asporin
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BCL6 B-cell CLL/lymphoma 6
BLNK B-cell linker
BSG basigin (Ok blood group)
BTG2 BTG family, member 2
CA1 carbonic anhydrase I
CA2 carbonic anhydrase II
CALB1 calbindin 1, 28kDa
CAST calpastatin
CAV1 caveolin 1, caveolae protein, 22kDa
CD52 CD52 molecule
CD9 CD9 molecule
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CFD complement factor D (adipsin)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLEC11A C-type lectin domain family 11, member A
CLU clusterin
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
CPE carboxypeptidase E
CST3 cystatin C
CYP2J2 cytochrome P450, family 2, subfamily J, polypeptide 2
EGFL6 EGF-like-domain, multiple 6
EGR1 early growth response 1
EMP1 epithelial membrane protein 1
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EPAS1 endothelial PAS domain protein 1
ERBB4 erb-b2 receptor tyrosine kinase 4
ESR1 estrogen receptor 1
F3 coagulation factor III (thromboplastin, tissue factor)
FAM107A family with sequence similarity 107, member A
FBLN1 fibulin 1
FBP1 fructose-1,6-bisphosphatase 1
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FGFR3 fibroblast growth factor receptor 3
FGL2 fibrinogen-like 2
FHL1 four and a half LIM domains 1
FLT1 fms-related tyrosine kinase 1
FOLR1 folate receptor 1 (adult)
FOS FBJ murine osteosarcoma viral oncogene homolog
FOXF1 forkhead box F1
FRY furry homolog (Drosophila)
GLUL glutamate-ammonia ligase
GM2A GM2 ganglioside activator
GNLY granulysin
GPM6A glycoprotein M6A
GPM6B glycoprotein M6B
GPR37 G protein-coupled receptor 37 (endothelin receptor type B-like)
HACD3 3-hydroxyacyl-CoA dehydratase 3
HES1 hes family bHLH transcription factor 1
HIST1H1C histone cluster 1, H1c
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IDS iduronate 2-sulfatase
IFITM1 interferon induced transmembrane protein 1
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IL1A interleukin 1, alpha
IL1RN interleukin 1 receptor antagonist
IRF6 interferon regulatory factor 6
ITFG1 integrin alpha FG-GAP repeat containing 1
ITM2C integral membrane protein 2C
JADE2 jade family PHD finger 2
JAG1 jagged 1
JAM2 junctional adhesion molecule 2
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
LAMP3 lysosomal-associated membrane protein 3
LGALS3 lectin, galactoside-binding, soluble, 3
LTBP1 latent transforming growth factor beta binding protein 1
LYN LYN proto-oncogene, Src family tyrosine kinase
MAN1A1 mannosidase, alpha, class 1A, member 1
MDFIC MyoD family inhibitor domain containing
MEF2C myocyte enhancer factor 2C
MEIS1 Meis homeobox 1
MEIS2 Meis homeobox 2
METRN meteorin, glial cell differentiation regulator
MMP12 matrix metallopeptidase 12
MMP9 matrix metallopeptidase 9
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1H metallothionein 1H
MT1X metallothionein 1X
NEBL nebulette
NR4A2 nuclear receptor subfamily 4, group A, member 2
NT5E 5'-nucleotidase, ecto (CD73)
PCDH17 protocadherin 17
PCSK1 proprotein convertase subtilisin/kexin type 1
PERP PERP, TP53 apoptosis effector
PGK1 phosphoglycerate kinase 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PKP2 plakophilin 2
PLVAP plasmalemma vesicle associated protein
PPT1 palmitoyl-protein thioesterase 1
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRKCB protein kinase C, beta
PTN pleiotrophin
PTPRC protein tyrosine phosphatase, receptor type, C
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RBP1 retinol binding protein 1, cellular
RBP4 retinol binding protein 4, plasma
RCAN2 regulator of calcineurin 2
RGCC regulator of cell cycle
RGS16 regulator of G-protein signaling 16
RGS5 regulator of G-protein signaling 5
RNASET2 ribonuclease T2
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SCG2 secretogranin II
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SELENBP1 selenium binding protein 1
SEPP1 selenoprotein P, plasma, 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SNX10 sorting nexin 10
SOX17 SRY (sex determining region Y)-box 17
SPARCL1 SPARC-like 1 (hevin)
STC1 stanniocalcin 1
SULF1 sulfatase 1
TF transferrin
TGFB1 transforming growth factor, beta 1
THY1 Thy-1 cell surface antigen
TIMP3 TIMP metallopeptidase inhibitor 3
TMEM231 transmembrane protein 231
TMEM47 transmembrane protein 47
TNNT1 troponin T type 1 (skeletal, slow)
TOX thymocyte selection-associated high mobility group box
TPBG trophoblast glycoprotein
TYROBP TYRO protein tyrosine kinase binding protein
VEGFA vascular endothelial growth factor A
WLS wntless Wnt ligand secretion mediator
ZNF331 zinc finger protein 331
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
AURKA aurora kinase A
BLMH bleomycin hydrolase
CCNA2 cyclin A2
CD24 CD24 molecule
CDC25B cell division cycle 25B
CHEK2 checkpoint kinase 2
CLTA clathrin, light chain A
COA3 cytochrome c oxidase assembly factor 3
CSE1L CSE1 chromosome segregation 1-like (yeast)
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYTL1 cytokine-like 1
DEGS1 delta(4)-desaturase, sphingolipid 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
EAPP E2F-associated phosphoprotein
EIF5A eukaryotic translation initiation factor 5A
FHL2 four and a half LIM domains 2
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GNAS GNAS complex locus
H2AFX H2A histone family, member X
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1
HOXC10 homeobox C10
HOXC6 homeobox C6
HSPA8 heat shock 70kDa protein 8
IGFBP4 insulin-like growth factor binding protein 4
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
KIF20A kinesin family member 20A
KRT10 keratin 10, type I
KRT15 keratin 15, type I
KRT7 keratin 7, type II
LAPTM4B lysosomal protein transmembrane 4 beta
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MALL mal, T-cell differentiation protein-like
MARCKS myristoylated alanine-rich protein kinase C substrate
NKX3-1 NK3 homeobox 1
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
NUP62 nucleoporin 62kDa
NXN nucleoredoxin
PACSIN2 protein kinase C and casein kinase substrate in neurons 2
PAX8 paired box 8
PCM1 pericentriolar material 1
PEG10 paternally expressed 10
QPCT glutaminyl-peptide cyclotransferase
RBPMS RNA binding protein with multiple splicing
RNPS1 RNA binding protein S1, serine-rich domain
RPL36AL ribosomal protein L36a-like
RRAS2 related RAS viral (r-ras) oncogene homolog 2
SACS sacsin molecular chaperone
SNX11 sorting nexin 11
TARS threonyl-tRNA synthetase
TBC1D4 TBC1 domain family, member 4
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFPI2 tissue factor pathway inhibitor 2
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TNPO1 transportin 1
TRAPPC3 trafficking protein particle complex 3
TXNDC9 thioredoxin domain containing 9
USP1 ubiquitin specific peptidase 1
VRK1 vaccinia related kinase 1
WDR6 WD repeat domain 6