BRD-K92571446_WZ-3105_BT20_3_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

98 genes differentially expressed following the BRD-K92571446_WZ-3105_BT20_3_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADD3 adducin 3 (gamma)
ADRB2 adrenoceptor beta 2, surface
APOD apolipoprotein D
BCAT1 branched chain amino-acid transaminase 1, cytosolic
BCL2A1 BCL2-related protein A1
CD59 CD59 molecule, complement regulatory protein
CFH complement factor H
CHGB chromogranin B
CXCL5 chemokine (C-X-C motif) ligand 5
DES desmin
ERAP1 endoplasmic reticulum aminopeptidase 1
FKBP11 FK506 binding protein 11, 19 kDa
FKBP1B FK506 binding protein 1B, 12.6 kDa
FOLR1 folate receptor 1 (adult)
G0S2 G0/G1 switch 2
GUSBP3 glucuronidase, beta pseudogene 3
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
NREP neuronal regeneration related protein
OAT ornithine aminotransferase
PAM peptidylglycine alpha-amidating monooxygenase
PAPSS1 3'-phosphoadenosine 5'-phosphosulfate synthase 1
PDE4DIP phosphodiesterase 4D interacting protein
PKP4 plakophilin 4
PRAME preferentially expressed antigen in melanoma
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SEPT11 septin 11
TSPAN8 tetraspanin 8
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative)
WIF1 WNT inhibitory factor 1
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble

decreased expression

Symbol Name
ADM adrenomedullin
ANPEP alanyl (membrane) aminopeptidase
ARID4B AT rich interactive domain 4B (RBP1-like)
AURKA aurora kinase A
BAMBI BMP and activin membrane-bound inhibitor
BCL6 B-cell CLL/lymphoma 6
CA2 carbonic anhydrase II
CCNE2 cyclin E2
CD24 CD24 molecule
CDC25A cell division cycle 25A
CDCA4 cell division cycle associated 4
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CYR61 cysteine-rich, angiogenic inducer, 61
DDX28 DEAD (Asp-Glu-Ala-Asp) box polypeptide 28
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
EFS embryonal Fyn-associated substrate
EGR2 early growth response 2
FOSL1 FOS-like antigen 1
FOXO1 forkhead box O1
FZD5 frizzled class receptor 5
FZD7 frizzled class receptor 7
GADD45A growth arrest and DNA-damage-inducible, alpha
GATA2 GATA binding protein 2
GOLT1B golgi transport 1B
GPRC5A G protein-coupled receptor, class C, group 5, member A
GSPT2 G1 to S phase transition 2
HES1 hes family bHLH transcription factor 1
HMOX1 heme oxygenase 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IER2 immediate early response 2
IER5 immediate early response 5
KRT15 keratin 15, type I
MCL1 myeloid cell leukemia 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NGDN neuroguidin, EIF4E binding protein
NR4A2 nuclear receptor subfamily 4, group A, member 2
PDZK1IP1 PDZK1 interacting protein 1
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PLK2 polo-like kinase 2
PPAP2B phosphatidic acid phosphatase type 2B
RBM15 RNA binding motif protein 15
RND3 Rho family GTPase 3
RNF138 ring finger protein 138, E3 ubiquitin protein ligase
RPP38 ribonuclease P/MRP 38kDa subunit
SASH1 SAM and SH3 domain containing 1
SCAF8 SR-related CTD-associated factor 8
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SMG8 SMG8 nonsense mediated mRNA decay factor
SPRED2 sprouty-related, EVH1 domain containing 2
TBPL1 TBP-like 1
TBX3 T-box 3
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TFF1 trefoil factor 1
TGIF1 TGFB-induced factor homeobox 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TLE4 transducin-like enhancer of split 4
TPBG trophoblast glycoprotein
WEE1 WEE1 G2 checkpoint kinase
ZFP36 ZFP36 ring finger protein
ZFP36L2 ZFP36 ring finger protein-like 2
ZHX2 zinc fingers and homeoboxes 2