BRD-K92571446_WZ-3105_BT20_24_h_0.12_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

168 genes differentially expressed following the BRD-K92571446_WZ-3105_BT20_24_h_0.12_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
AKAP12 A kinase (PRKA) anchor protein 12
AQP9 aquaporin 9
ARG1 arginase 1
ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b
ATP6V0E2 ATPase, H+ transporting V0 subunit e2
BAG3 BCL2-associated athanogene 3
BCAT1 branched chain amino-acid transaminase 1, cytosolic
BCL6 B-cell CLL/lymphoma 6
CADM1 cell adhesion molecule 1
CCL19 chemokine (C-C motif) ligand 19
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLU clusterin
COL6A3 collagen, type VI, alpha 3
CPE carboxypeptidase E
CSRP2 cysteine and glycine-rich protein 2
CST3 cystatin C
CSTA cystatin A (stefin A)
CTSL cathepsin L
CTTN cortactin
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL8 chemokine (C-X-C motif) ligand 8
DEFB1 defensin, beta 1
DUSP2 dual specificity phosphatase 2
EGR1 early growth response 1
EGR3 early growth response 3
ENC1 ectodermal-neural cortex 1 (with BTB domain)
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
ESR1 estrogen receptor 1
ETNPPL ethanolamine-phosphate phospho-lyase
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FASTKD5 FAST kinase domains 5
FERMT2 fermitin family member 2
FGFR1 fibroblast growth factor receptor 1
FUCA1 fucosidase, alpha-L- 1, tissue
G0S2 G0/G1 switch 2
GMPR guanosine monophosphate reductase
GPNMB glycoprotein (transmembrane) nmb
H2BFS H2B histone family, member S (pseudogene)
HIST1H1C histone cluster 1, H1c
HIST1H2BD histone cluster 1, H2bd
HIST1H2BF histone cluster 1, H2bf
HIST1H2BG histone cluster 1, H2bg
HIST1H2BH histone cluster 1, H2bh
HIST1H2BK histone cluster 1, H2bk
HLA-DPB1 major histocompatibility complex, class II, DP beta 1
HSPA1A heat shock 70kDa protein 1A
IER3 immediate early response 3
IGF1 insulin-like growth factor 1 (somatomedin C)
IGFBP3 insulin-like growth factor binding protein 3
IL1R1 interleukin 1 receptor, type I
IL1RN interleukin 1 receptor antagonist
IL6 interleukin 6
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAN2B1 mannosidase, alpha, class 2B, member 1
METTL7A methyltransferase like 7A
MMP9 matrix metallopeptidase 9
MT1X metallothionein 1X
MYH11 myosin, heavy chain 11, smooth muscle
MYLK myosin light chain kinase
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NUAK1 NUAK family, SNF1-like kinase, 1
PCBP2 poly(rC) binding protein 2
PCLO piccolo presynaptic cytomatrix protein
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1
PLA2G7 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTN pleiotrophin
RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis)
RPS4Y1 ribosomal protein S4, Y-linked 1
SDC2 syndecan 2
SEPP1 selenoprotein P, plasma, 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SFN stratifin
SH3BGRL SH3 domain binding glutamate-rich protein like
SKP1 S-phase kinase-associated protein 1
SPARCL1 SPARC-like 1 (hevin)
STC1 stanniocalcin 1
STK17A serine/threonine kinase 17a
STK39 serine threonine kinase 39
TCF4 transcription factor 4
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TMSB15A thymosin beta 15a
TPSAB1 tryptase alpha/beta 1
TSC22D3 TSC22 domain family, member 3
WT1 Wilms tumor 1
ZNF423 zinc finger protein 423

decreased expression

Symbol Name
ADGRG6 adhesion G protein-coupled receptor G6
ALCAM activated leukocyte cell adhesion molecule
ALOX5 arachidonate 5-lipoxygenase
AMIGO2 adhesion molecule with Ig-like domain 2
ANXA3 annexin A3
ARFIP2 ADP-ribosylation factor interacting protein 2
BASP1 brain abundant, membrane attached signal protein 1
C1ORF106 chromosome 1 open reading frame 106
CASP8AP2 caspase 8 associated protein 2
CAV2 caveolin 2
CCND2 cyclin D2
CD24 CD24 molecule
CDC25B cell division cycle 25B
COA3 cytochrome c oxidase assembly factor 3
CXCL11 chemokine (C-X-C motif) ligand 11
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EFNA1 ephrin-A1
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2
ERBB2 erb-b2 receptor tyrosine kinase 2
FAM57A family with sequence similarity 57, member A
FGFR4 fibroblast growth factor receptor 4
FNDC3B fibronectin type III domain containing 3B
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GOLGA8A golgin A8 family, member A
IFI44L interferon-induced protein 44-like
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
KIAA0125 KIAA0125
KRT7 keratin 7, type II
LAPTM4B lysosomal protein transmembrane 4 beta
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
MANSC1 MANSC domain containing 1
MAPK13 mitogen-activated protein kinase 13
MRPL12 mitochondrial ribosomal protein L12
MRPS16 mitochondrial ribosomal protein S16
MYBPC1 myosin binding protein C, slow type
N4BP2L2 NEDD4 binding protein 2-like 2
NEB nebulin
NFIB nuclear factor I/B
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NMI N-myc (and STAT) interactor
NT5E 5'-nucleotidase, ecto (CD73)
OBSL1 obscurin-like 1
PDZRN3 PDZ domain containing ring finger 3
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta
PLAC8 placenta-specific 8
PLCB4 phospholipase C, beta 4
PLXNC1 plexin C1
PNMA2 paraneoplastic Ma antigen 2
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa
PPAP2C phosphatidic acid phosphatase type 2C
PRMT1 protein arginine methyltransferase 1
PROM1 prominin 1
PTP4A1 protein tyrosine phosphatase type IVA, member 1
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SF3B3 splicing factor 3b, subunit 3, 130kDa
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLPI secretory leukocyte peptidase inhibitor
STAT1 signal transducer and activator of transcription 1, 91kDa
SVIL supervillin
TES testin LIM domain protein
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TNS3 tensin 3
TOX3 TOX high mobility group box family member 3
TP53 tumor protein p53
TPD52L1 tumor protein D52-like 1
TPM1 tropomyosin 1 (alpha)
TRIM14 tripartite motif containing 14
TRIM16 tripartite motif containing 16
TRIP6 thyroid hormone receptor interactor 6
TSPAN8 tetraspanin 8
TTN titin
VCAN versican