BRD-K92571446_WZ-3105_A549_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

263 genes differentially expressed following the BRD-K92571446_WZ-3105_A549_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ACKR3 atypical chemokine receptor 3
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADI1 acireductone dioxygenase 1
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ANOS1 anosmin 1
APLP2 amyloid beta (A4) precursor-like protein 2
APOBEC3G apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G
AQP1 aquaporin 1 (Colton blood group)
ASPN asporin
ATF3 activating transcription factor 3
C1ORF54 chromosome 1 open reading frame 54
C3 complement component 3
C9ORF16 chromosome 9 open reading frame 16
CADM1 cell adhesion molecule 1
CALD1 caldesmon 1
CASP1 caspase 1, apoptosis-related cysteine peptidase
CASP10 caspase 10, apoptosis-related cysteine peptidase
CCL2 chemokine (C-C motif) ligand 2
CCL20 chemokine (C-C motif) ligand 20
CCL5 chemokine (C-C motif) ligand 5
CCL8 chemokine (C-C motif) ligand 8
CCNA1 cyclin A1
CD14 CD14 molecule
CD163 CD163 molecule
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CD93 CD93 molecule
CFB complement factor B
CFI complement factor I
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
COG5 component of oligomeric golgi complex 5
COL11A1 collagen, type XI, alpha 1
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
COL6A2 collagen, type VI, alpha 2
COLEC12 collectin sub-family member 12
CPE carboxypeptidase E
CPQ carboxypeptidase Q
CSRP2 cysteine and glycine-rich protein 2
CTGF connective tissue growth factor
CTSB cathepsin B
CTSO cathepsin O
CUTA cutA divalent cation tolerance homolog (E. coli)
CXCL10 chemokine (C-X-C motif) ligand 10
CYR61 cysteine-rich, angiogenic inducer, 61
DDOST dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit (non-catalytic)
DKK3 dickkopf WNT signaling pathway inhibitor 3
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15
DPYSL3 dihydropyrimidinase-like 3
ECM2 extracellular matrix protein 2, female organ and adipocyte specific
EFNA1 ephrin-A1
EGR1 early growth response 1
EGR2 early growth response 2
EGR3 early growth response 3
EIF5A eukaryotic translation initiation factor 5A
EMP1 epithelial membrane protein 1
EPCAM epithelial cell adhesion molecule
ESR1 estrogen receptor 1
F3 coagulation factor III (thromboplastin, tissue factor)
FABP4 fatty acid binding protein 4, adipocyte
FAM198B family with sequence similarity 198, member B
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GBP1 guanylate binding protein 1, interferon-inducible
GPER1 G protein-coupled estrogen receptor 1
GPM6A glycoprotein M6A
GPM6B glycoprotein M6B
GPNMB glycoprotein (transmembrane) nmb
GRIA2 glutamate receptor, ionotropic, AMPA 2
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
GUCY1B3 guanylate cyclase 1, soluble, beta 3
HDAC9 histone deacetylase 9
HIST1H1C histone cluster 1, H1c
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HLA-F major histocompatibility complex, class I, F
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IDO1 indoleamine 2,3-dioxygenase 1
IER3 immediate early response 3
IFI6 interferon, alpha-inducible protein 6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFITM1 interferon induced transmembrane protein 1
IFITM2 interferon induced transmembrane protein 2
IFITM3 interferon induced transmembrane protein 3
IGFBP7 insulin-like growth factor binding protein 7
IGLL1 immunoglobulin lambda-like polypeptide 1
IL13RA2 interleukin 13 receptor, alpha 2
IL1B interleukin 1, beta
IL7R interleukin 7 receptor
ISG15 ISG15 ubiquitin-like modifier
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
JUN jun proto-oncogene
LAMP2 lysosomal-associated membrane protein 2
LDB2 LIM domain binding 2
LEF1 lymphoid enhancer-binding factor 1
LOX lysyl oxidase
LRRC17 leucine rich repeat containing 17
LTBP1 latent transforming growth factor beta binding protein 1
LY96 lymphocyte antigen 96
MCUR1 mitochondrial calcium uniporter regulator 1
MECOM MDS1 and EVI1 complex locus
MME membrane metallo-endopeptidase
MMP9 matrix metallopeptidase 9
MS4A4A membrane-spanning 4-domains, subfamily A, member 4A
MSX1 msh homeobox 1
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1X metallothionein 1X
MXRA5 matrix-remodelling associated 5
MXRA7 matrix-remodelling associated 7
MYL9 myosin, light chain 9, regulatory
NDUFA13 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13
NDUFC2 NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 2, 14.5kDa
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A3 nuclear receptor subfamily 4, group A, member 3
ORM1 orosomucoid 1
OSR2 odd-skipped related transciption factor 2
PCDH7 protocadherin 7
PDE8B phosphodiesterase 8B
PDZD2 PDZ domain containing 2
PHACTR1 phosphatase and actin regulator 1
PLAT plasminogen activator, tissue
PLAU plasminogen activator, urokinase
PLTP phospholipid transfer protein
PLVAP plasmalemma vesicle associated protein
PLXDC1 plexin domain containing 1
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPT1 palmitoyl-protein thioesterase 1
PRDX2 peroxiredoxin 2
PRDX4 peroxiredoxin 4
PRKCI protein kinase C, iota
PTPRC protein tyrosine phosphatase, receptor type, C
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RBP1 retinol binding protein 1, cellular
RGL1 ral guanine nucleotide dissociation stimulator-like 1
RGS10 regulator of G-protein signaling 10
RGS16 regulator of G-protein signaling 16
RGS5 regulator of G-protein signaling 5
RSAD2 radical S-adenosyl methionine domain containing 2
S100A2 S100 calcium binding protein A2
SAT1 spermidine/spermine N1-acetyltransferase 1
SCD5 stearoyl-CoA desaturase 5
SCG2 secretogranin II
SCGB2A1 secretoglobin, family 2A, member 1
SDC2 syndecan 2
SEPP1 selenoprotein P, plasma, 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SFN stratifin
SFRP4 secreted frizzled-related protein 4
SOD2 superoxide dismutase 2, mitochondrial
SOX17 SRY (sex determining region Y)-box 17
SPARCL1 SPARC-like 1 (hevin)
SPON1 spondin 1, extracellular matrix protein
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma)
SSR4 signal sequence receptor, delta
STAP2 signal transducing adaptor family member 2
STC1 stanniocalcin 1
SULF1 sulfatase 1
TDO2 tryptophan 2,3-dioxygenase
THBS1 thrombospondin 1
THY1 Thy-1 cell surface antigen
TIMP3 TIMP metallopeptidase inhibitor 3
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMSB15A thymosin beta 15a
TPP1 tripeptidyl peptidase I
TRD T cell receptor delta locus
TRDV3 T cell receptor delta variable 3
TTC3 tetratricopeptide repeat domain 3
TXNIP thioredoxin interacting protein
VEGFA vascular endothelial growth factor A
VNN1 vanin 1
WASF3 WAS protein family, member 3
WIF1 WNT inhibitory factor 1
WLS wntless Wnt ligand secretion mediator

decreased expression

Symbol Name
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ADGRG2 adhesion G protein-coupled receptor G2
ADGRG6 adhesion G protein-coupled receptor G6
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
AQP3 aquaporin 3 (Gill blood group)
ASCC3 activating signal cointegrator 1 complex subunit 3
ASXL2 additional sex combs like transcriptional regulator 2
ATMIN ATM interactor
AURKA aurora kinase A
BASP1 brain abundant, membrane attached signal protein 1
BAZ1A bromodomain adjacent to zinc finger domain, 1A
BLMH bleomycin hydrolase
BRCA1 breast cancer 1, early onset
CA12 carbonic anhydrase XII
CBX6 chromobox homolog 6
CCNA2 cyclin A2
CCNB2 cyclin B2
CDC25B cell division cycle 25B
CDC42EP4 CDC42 effector protein (Rho GTPase binding) 4
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CHPT1 choline phosphotransferase 1
DDIT4 DNA-damage-inducible transcript 4
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
EAPP E2F-associated phosphoprotein
ERBB2 erb-b2 receptor tyrosine kinase 2
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FBL fibrillarin
GNE glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
GPX2 glutathione peroxidase 2
GRB10 growth factor receptor-bound protein 10
HOXC6 homeobox C6
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPA2 heat shock 70kDa protein 2
HSPA8 heat shock 70kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
IGFBP4 insulin-like growth factor binding protein 4
IL1R2 interleukin 1 receptor, type II
IRS2 insulin receptor substrate 2
KAZN kazrin, periplakin interacting protein
KRT7 keratin 7, type II
MAL mal, T-cell differentiation protein
MALL mal, T-cell differentiation protein-like
MED1 mediator complex subunit 1
MELK maternal embryonic leucine zipper kinase
MTCL1 microtubule crosslinking factor 1
MTUS1 microtubule associated tumor suppressor 1
MYBPC1 myosin binding protein C, slow type
MYO10 myosin X
MYO1E myosin IE
NAV2 neuron navigator 2
PCM1 pericentriolar material 1
PDE4B phosphodiesterase 4B, cAMP-specific
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta
PLAC8 placenta-specific 8
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2)
PRKCA protein kinase C, alpha
RAB4A RAB4A, member RAS oncogene family
RGS2 regulator of G-protein signaling 2
RNF111 ring finger protein 111
S100P S100 calcium binding protein P
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SGCE sarcoglycan, epsilon
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SPINK1 serine peptidase inhibitor, Kazal type 1
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
TACC2 transforming, acidic coiled-coil containing protein 2
TFF1 trefoil factor 1
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TOX3 TOX high mobility group box family member 3
TRIM16 tripartite motif containing 16
TSPYL5 TSPY-like 5
UGDH UDP-glucose 6-dehydrogenase
XBP1 X-box binding protein 1
YBX3 Y box binding protein 3
ZMYM2 zinc finger, MYM-type 2