BRD-K92571446_WZ-3105_A549_24_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

247 genes differentially expressed following the BRD-K92571446_WZ-3105_A549_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ACKR3 atypical chemokine receptor 3
ADD3 adducin 3 (gamma)
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADIRF adipogenesis regulatory factor
AIF1 allograft inflammatory factor 1
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ANO1 anoctamin 1, calcium activated chloride channel
ANOS1 anosmin 1
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
AQP1 aquaporin 1 (Colton blood group)
ASPN asporin
ATF3 activating transcription factor 3
ATM ATM serine/threonine kinase
BDH1 3-hydroxybutyrate dehydrogenase, type 1
BEX1 brain expressed, X-linked 1
BHLHE41 basic helix-loop-helix family, member e41
C1ORF54 chromosome 1 open reading frame 54
C3 complement component 3
CADM1 cell adhesion molecule 1
CCL4 chemokine (C-C motif) ligand 4
CCL5 chemokine (C-C motif) ligand 5
CCL8 chemokine (C-C motif) ligand 8
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CFB complement factor B
CFI complement factor I
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
COL11A1 collagen, type XI, alpha 1
COL1A2 collagen, type I, alpha 2
COLEC12 collectin sub-family member 12
CPE carboxypeptidase E
CPVL carboxypeptidase, vitellogenic-like
CTGF connective tissue growth factor
CTSK cathepsin K
CTSO cathepsin O
CXCL10 chemokine (C-X-C motif) ligand 10
CXCR4 chemokine (C-X-C motif) receptor 4
CYP2J2 cytochrome P450, family 2, subfamily J, polypeptide 2
CYR61 cysteine-rich, angiogenic inducer, 61
DDR2 discoidin domain receptor tyrosine kinase 2
DENND2D DENN/MADD domain containing 2D
DKK3 dickkopf WNT signaling pathway inhibitor 3
ECM1 extracellular matrix protein 1
ECM2 extracellular matrix protein 2, female organ and adipocyte specific
EFNB2 ephrin-B2
EGFL6 EGF-like-domain, multiple 6
EGR1 early growth response 1
EGR2 early growth response 2
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EPCAM epithelial cell adhesion molecule
ESR1 estrogen receptor 1
FABP4 fatty acid binding protein 4, adipocyte
FAM107A family with sequence similarity 107, member A
FAP fibroblast activation protein, alpha
FBP1 fructose-1,6-bisphosphatase 1
FGL2 fibrinogen-like 2
FHL1 four and a half LIM domains 1
FLT1 fms-related tyrosine kinase 1
FMO2 flavin containing monooxygenase 2 (non-functional)
FOLR1 folate receptor 1 (adult)
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FXYD6 FXYD domain containing ion transport regulator 6
GADD45B growth arrest and DNA-damage-inducible, beta
GLT8D2 glycosyltransferase 8 domain containing 2
GM2A GM2 ganglioside activator
GPER1 G protein-coupled estrogen receptor 1
GPM6A glycoprotein M6A
GPNMB glycoprotein (transmembrane) nmb
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HDAC9 histone deacetylase 9
HIST1H1C histone cluster 1, H1c
HLA-DMA major histocompatibility complex, class II, DM alpha
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HLA-DPB1 major histocompatibility complex, class II, DP beta 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
IDO1 indoleamine 2,3-dioxygenase 1
IFI6 interferon, alpha-inducible protein 6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFITM1 interferon induced transmembrane protein 1
IFITM3 interferon induced transmembrane protein 3
IGFBP7 insulin-like growth factor binding protein 7
IL13RA2 interleukin 13 receptor, alpha 2
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
INHBA inhibin, beta A
IRF6 interferon regulatory factor 6
ISG15 ISG15 ubiquitin-like modifier
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
JAM2 junctional adhesion molecule 2
LAMP3 lysosomal-associated membrane protein 3
LAPTM5 lysosomal protein transmembrane 5
LCN2 lipocalin 2
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
LDB2 LIM domain binding 2
LEF1 lymphoid enhancer-binding factor 1
LRRC17 leucine rich repeat containing 17
LY96 lymphocyte antigen 96
MATN2 matrilin 2
MCUR1 mitochondrial calcium uniporter regulator 1
MEF2C myocyte enhancer factor 2C
MEIS1 Meis homeobox 1
MME membrane metallo-endopeptidase
MMP9 matrix metallopeptidase 9
MT1E metallothionein 1E
MT1F metallothionein 1F
MXRA5 matrix-remodelling associated 5
MYLK myosin light chain kinase
PAK6 p21 protein (Cdc42/Rac)-activated kinase 6
PDIA3 protein disulfide isomerase family A, member 3
PECAM1 platelet/endothelial cell adhesion molecule 1
PHACTR1 phosphatase and actin regulator 1
PLAT plasminogen activator, tissue
PLAU plasminogen activator, urokinase
PLTP phospholipid transfer protein
PLVAP plasmalemma vesicle associated protein
PLXDC1 plexin domain containing 1
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PSPH phosphoserine phosphatase
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTPRC protein tyrosine phosphatase, receptor type, C
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RBP1 retinol binding protein 1, cellular
RGS10 regulator of G-protein signaling 10
RGS16 regulator of G-protein signaling 16
RGS5 regulator of G-protein signaling 5
RSAD2 radical S-adenosyl methionine domain containing 2
SCD5 stearoyl-CoA desaturase 5
SCG5 secretogranin V
SELE selectin E
SERINC5 serine incorporator 5
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SFRP4 secreted frizzled-related protein 4
SLC25A14 solute carrier family 25 (mitochondrial carrier, brain), member 14
SLC35A3 solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3
SOD2 superoxide dismutase 2, mitochondrial
SORT1 sortilin 1
SOX17 SRY (sex determining region Y)-box 17
SPARCL1 SPARC-like 1 (hevin)
SPINT1 serine peptidase inhibitor, Kunitz type 1
SPON1 spondin 1, extracellular matrix protein
STAP2 signal transducing adaptor family member 2
STC1 stanniocalcin 1
STON1 stonin 1
SULF1 sulfatase 1
TCF4 transcription factor 4
TDO2 tryptophan 2,3-dioxygenase
THBS2 thrombospondin 2
THY1 Thy-1 cell surface antigen
TIMP3 TIMP metallopeptidase inhibitor 3
TMEM176A transmembrane protein 176A
TMEM176B transmembrane protein 176B
TMEM231 transmembrane protein 231
TMEM47 transmembrane protein 47
TMOD1 tropomodulin 1
TMSB15A thymosin beta 15a
TPP1 tripeptidyl peptidase I
TWIST1 twist family bHLH transcription factor 1
VNN1 vanin 1
WASF3 WAS protein family, member 3
WFDC2 WAP four-disulfide core domain 2
WLS wntless Wnt ligand secretion mediator
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
ADGRG2 adhesion G protein-coupled receptor G2
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
AQP3 aquaporin 3 (Gill blood group)
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2
ASCC3 activating signal cointegrator 1 complex subunit 3
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
AURKA aurora kinase A
AUTS2 autism susceptibility candidate 2
BTG1 B-cell translocation gene 1, anti-proliferative
CA12 carbonic anhydrase XII
CCNA2 cyclin A2
CCNB2 cyclin B2
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CXCL14 chemokine (C-X-C motif) ligand 14
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EPS8 epidermal growth factor receptor pathway substrate 8
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM13A family with sequence similarity 13, member A
FBL fibrillarin
GLOD4 glyoxalase domain containing 4
GPX2 glutathione peroxidase 2
GRWD1 glutamate-rich WD repeat containing 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPA1A heat shock 70kDa protein 1A
HSPA8 heat shock 70kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
IGF1R insulin-like growth factor 1 receptor
IGFBP4 insulin-like growth factor binding protein 4
IL1R2 interleukin 1 receptor, type II
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
KIF23 kinesin family member 23
KRT15 keratin 15, type I
KRT7 keratin 7, type II
LASP1 LIM and SH3 protein 1
LTF lactotransferrin
MALL mal, T-cell differentiation protein-like
MED1 mediator complex subunit 1
MRPS2 mitochondrial ribosomal protein S2
MTCL1 microtubule crosslinking factor 1
MYBPC1 myosin binding protein C, slow type
MYO10 myosin X
NQO1 NAD(P)H dehydrogenase, quinone 1
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PBK PDZ binding kinase
PCNA proliferating cell nuclear antigen
PDE4B phosphodiesterase 4B, cAMP-specific
PDE4D phosphodiesterase 4D, cAMP-specific
PFKP phosphofructokinase, platelet
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta
PKM pyruvate kinase, muscle
PLK1 polo-like kinase 1
PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2)
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
PRKCA protein kinase C, alpha
PSMD11 proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
RACGAP1 Rac GTPase activating protein 1
RAE1 ribonucleic acid export 1
RGS2 regulator of G-protein signaling 2
RNPS1 RNA binding protein S1, serine-rich domain
S100P S100 calcium binding protein P
SACS sacsin molecular chaperone
SFN stratifin
SMC4 structural maintenance of chromosomes 4
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TM4SF1 transmembrane 4 L six family member 1
TMEM97 transmembrane protein 97
TOMM70A translocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae)
TSKU tsukushi, small leucine rich proteoglycan
UBE2C ubiquitin-conjugating enzyme E2C
UGDH UDP-glucose 6-dehydrogenase
YBX3 Y box binding protein 3