BRD-K92571446_WZ-3105_A549_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

262 genes differentially expressed following the BRD-K92571446_WZ-3105_A549_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ACKR3 atypical chemokine receptor 3
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADIPOQ adiponectin, C1Q and collagen domain containing
ADIRF adipogenesis regulatory factor
AIF1 allograft inflammatory factor 1
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ANO1 anoctamin 1, calcium activated chloride channel
ANOS1 anosmin 1
APOBEC3G apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G
AQP1 aquaporin 1 (Colton blood group)
ASPN asporin
ATF3 activating transcription factor 3
ATP6V0E2 ATPase, H+ transporting V0 subunit e2
C1ORF54 chromosome 1 open reading frame 54
C3 complement component 3
C9ORF16 chromosome 9 open reading frame 16
CADM1 cell adhesion molecule 1
CCL2 chemokine (C-C motif) ligand 2
CCL20 chemokine (C-C motif) ligand 20
CCL4 chemokine (C-C motif) ligand 4
CCL5 chemokine (C-C motif) ligand 5
CCL8 chemokine (C-C motif) ligand 8
CD14 CD14 molecule
CD163 CD163 molecule
CD36 CD36 molecule (thrombospondin receptor)
CD48 CD48 molecule
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CD9 CD9 molecule
CD93 CD93 molecule
CDO1 cysteine dioxygenase type 1
CFB complement factor B
CFI complement factor I
CHRDL1 chordin-like 1
CLU clusterin
COL11A1 collagen, type XI, alpha 1
COL6A2 collagen, type VI, alpha 2
CPE carboxypeptidase E
CSRP2 cysteine and glycine-rich protein 2
CTGF connective tissue growth factor
CTSB cathepsin B
CUX2 cut-like homeobox 2
CXCL10 chemokine (C-X-C motif) ligand 10
CYR61 cysteine-rich, angiogenic inducer, 61
DDR1 discoidin domain receptor tyrosine kinase 1
DKK3 dickkopf WNT signaling pathway inhibitor 3
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15
DPYSL3 dihydropyrimidinase-like 3
DSP desmoplakin
EGR1 early growth response 1
EGR2 early growth response 2
EGR3 early growth response 3
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
EIF5A eukaryotic translation initiation factor 5A
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EPCAM epithelial cell adhesion molecule
ESR1 estrogen receptor 1
F13A1 coagulation factor XIII, A1 polypeptide
F3 coagulation factor III (thromboplastin, tissue factor)
FABP4 fatty acid binding protein 4, adipocyte
FAM198B family with sequence similarity 198, member B
FBLN1 fibulin 1
FCGR1B Fc fragment of IgG, high affinity Ib, receptor (CD64)
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FZD1 frizzled class receptor 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GLUL glutamate-ammonia ligase
GNL3L guanine nucleotide binding protein-like 3 (nucleolar)-like
GPM6A glycoprotein M6A
GPM6B glycoprotein M6B
GPNMB glycoprotein (transmembrane) nmb
GPR183 G protein-coupled receptor 183
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HDAC9 histone deacetylase 9
HIST1H1C histone cluster 1, H1c
HIST1H2BC histone cluster 1, H2bc
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HLA-DPB1 major histocompatibility complex, class II, DP beta 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HLA-F major histocompatibility complex, class I, F
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IDO1 indoleamine 2,3-dioxygenase 1
IER3 immediate early response 3
IFI27 interferon, alpha-inducible protein 27
IFI30 interferon, gamma-inducible protein 30
IFI6 interferon, alpha-inducible protein 6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFITM1 interferon induced transmembrane protein 1
IFITM2 interferon induced transmembrane protein 2
IFITM3 interferon induced transmembrane protein 3
IGFBP7 insulin-like growth factor binding protein 7
IL13RA2 interleukin 13 receptor, alpha 2
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
IL7R interleukin 7 receptor
ISG15 ISG15 ubiquitin-like modifier
KRT23 keratin 23, type I
LAGE3 L antigen family, member 3
LAMP1 lysosomal-associated membrane protein 1
LCN2 lipocalin 2
LDB2 LIM domain binding 2
LEF1 lymphoid enhancer-binding factor 1
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LPPR4 lipid phosphate phosphatase-related protein type 4
LRRC17 leucine rich repeat containing 17
MCUR1 mitochondrial calcium uniporter regulator 1
MME membrane metallo-endopeptidase
MMP9 matrix metallopeptidase 9
MS4A4A membrane-spanning 4-domains, subfamily A, member 4A
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1X metallothionein 1X
MXRA5 matrix-remodelling associated 5
MXRA7 matrix-remodelling associated 7
MYL9 myosin, light chain 9, regulatory
NDUFC2 NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 2, 14.5kDa
NELL2 NEL-like 2 (chicken)
NMU neuromedin U
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A3 nuclear receptor subfamily 4, group A, member 3
OLR1 oxidized low density lipoprotein (lectin-like) receptor 1
ORM1 orosomucoid 1
PAK6 p21 protein (Cdc42/Rac)-activated kinase 6
PCDH7 protocadherin 7
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PDE8B phosphodiesterase 8B
PDIA3 protein disulfide isomerase family A, member 3
PDZD2 PDZ domain containing 2
PHACTR1 phosphatase and actin regulator 1
PLAU plasminogen activator, urokinase
PLTP phospholipid transfer protein
PLVAP plasmalemma vesicle associated protein
PPT1 palmitoyl-protein thioesterase 1
PRDX2 peroxiredoxin 2
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRSS21 protease, serine, 21 (testisin)
PTPRC protein tyrosine phosphatase, receptor type, C
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RBP1 retinol binding protein 1, cellular
RBP4 retinol binding protein 4, plasma
REEP1 receptor accessory protein 1
RGS10 regulator of G-protein signaling 10
RGS16 regulator of G-protein signaling 16
RGS5 regulator of G-protein signaling 5
RSAD2 radical S-adenosyl methionine domain containing 2
RTN1 reticulon 1
S100A8 S100 calcium binding protein A8
SAT1 spermidine/spermine N1-acetyltransferase 1
SCG2 secretogranin II
SCGB2A1 secretoglobin, family 2A, member 1
SCUBE2 signal peptide, CUB domain, EGF-like 2
SDC2 syndecan 2
SEPP1 selenoprotein P, plasma, 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SFN stratifin
SFRP4 secreted frizzled-related protein 4
SLC26A4 solute carrier family 26 (anion exchanger), member 4
SNAI2 snail family zinc finger 2
SOD2 superoxide dismutase 2, mitochondrial
SOX17 SRY (sex determining region Y)-box 17
SPARCL1 SPARC-like 1 (hevin)
STC1 stanniocalcin 1
SULF1 sulfatase 1
TGFB3 transforming growth factor, beta 3
THBS1 thrombospondin 1
THBS2 thrombospondin 2
THY1 Thy-1 cell surface antigen
TIMP3 TIMP metallopeptidase inhibitor 3
TMEM14B transmembrane protein 14B
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM30B transmembrane protein 30B
TMSB15A thymosin beta 15a
TRD T cell receptor delta locus
TRDV3 T cell receptor delta variable 3
TTC3 tetratricopeptide repeat domain 3
TWIST1 twist family bHLH transcription factor 1
TXNIP thioredoxin interacting protein
VDAC1 voltage-dependent anion channel 1
VNN1 vanin 1
VSIG4 V-set and immunoglobulin domain containing 4
VTCN1 V-set domain containing T cell activation inhibitor 1
WIF1 WNT inhibitory factor 1

decreased expression

Symbol Name
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ACBD3 acyl-CoA binding domain containing 3
ADGRG2 adhesion G protein-coupled receptor G2
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
AQP3 aquaporin 3 (Gill blood group)
ASCC3 activating signal cointegrator 1 complex subunit 3
ASXL2 additional sex combs like transcriptional regulator 2
BASP1 brain abundant, membrane attached signal protein 1
BLMH bleomycin hydrolase
CASP7 caspase 7, apoptosis-related cysteine peptidase
CCNB2 cyclin B2
CDC25B cell division cycle 25B
CDC42EP4 CDC42 effector protein (Rho GTPase binding) 4
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CHMP6 charged multivesicular body protein 6
DGKD diacylglycerol kinase, delta 130kDa
DKK1 dickkopf WNT signaling pathway inhibitor 1
ELANE elastase, neutrophil expressed
ERBB2 erb-b2 receptor tyrosine kinase 2
FBL fibrillarin
GAREM GRB2 associated, regulator of MAPK1
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type
GPX2 glutathione peroxidase 2
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPA8 heat shock 70kDa protein 8
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP4 insulin-like growth factor binding protein 4
IRS2 insulin receptor substrate 2
KAZN kazrin, periplakin interacting protein
KLF4 Kruppel-like factor 4 (gut)
KRT7 keratin 7, type II
LGR4 leucine-rich repeat containing G protein-coupled receptor 4
LIMCH1 LIM and calponin homology domains 1
LTF lactotransferrin
MAL mal, T-cell differentiation protein
MALL mal, T-cell differentiation protein-like
MB myoglobin
MELK maternal embryonic leucine zipper kinase
MTRR 5-methyltetrahydrofolate-homocysteine methyltransferase reductase
MTUS1 microtubule associated tumor suppressor 1
MYBPC1 myosin binding protein C, slow type
MYO10 myosin X
NUP85 nucleoporin 85kDa
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PDE4B phosphodiesterase 4B, cAMP-specific
PEG10 paternally expressed 10
PFKP phosphofructokinase, platelet
PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2)
PRKCA protein kinase C, alpha
PRKD3 protein kinase D3
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTP4A1 protein tyrosine phosphatase type IVA, member 1
RGS2 regulator of G-protein signaling 2
RNF111 ring finger protein 111
RRAS2 related RAS viral (r-ras) oncogene homolog 2
S100P S100 calcium binding protein P
SLC38A2 solute carrier family 38, member 2
SRGN serglycin
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
TACC2 transforming, acidic coiled-coil containing protein 2
TFF1 trefoil factor 1
TOX3 TOX high mobility group box family member 3
TRIM16 tripartite motif containing 16
TSPYL5 TSPY-like 5
URI1 URI1, prefoldin-like chaperone
XBP1 X-box binding protein 1