BRD-K92428232_GSK-461364_MCF7_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

137 genes differentially expressed following the BRD-K92428232_GSK-461364_MCF7_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
AMIGO2 adhesion molecule with Ig-like domain 2
AUTS2 autism susceptibility candidate 2
CCL5 chemokine (C-C motif) ligand 5
CDA cytidine deaminase
CLIC3 chloride intracellular channel 3
CLSTN1 calsyntenin 1
COCH cochlin
COTL1 coactosin-like F-actin binding protein 1
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXCL3 chemokine (C-X-C motif) ligand 3
DACH1 dachshund family transcription factor 1
DMD dystrophin
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3
FKBP11 FK506 binding protein 11, 19 kDa
FLRT2 fibronectin leucine rich transmembrane protein 2
GATA6 GATA binding protein 6
GHR growth hormone receptor
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2
HSPB8 heat shock 22kDa protein 8
IGHM immunoglobulin heavy constant mu
MBTPS1 membrane-bound transcription factor peptidase, site 1
MEF2C myocyte enhancer factor 2C
MICAL1 microtubule associated monooxygenase, calponin and LIM domain containing 1
NSMF NMDA receptor synaptonuclear signaling and neuronal migration factor
P3H2 prolyl 3-hydroxylase 2
PCSK6 proprotein convertase subtilisin/kexin type 6
PHLDA1 pleckstrin homology-like domain, family A, member 1
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLBD1 phospholipase B domain containing 1
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific)
PODXL podocalyxin-like
PRKCZ protein kinase C, zeta
PROM1 prominin 1
PTGER2 prostaglandin E receptor 2 (subtype EP2), 53kDa
RBM25 RNA binding motif protein 25
RBP1 retinol binding protein 1, cellular
RHOC ras homolog family member C
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SRPX sushi-repeat containing protein, X-linked
TCL1A T-cell leukemia/lymphoma 1A
TPM1 tropomyosin 1 (alpha)
U2AF1 U2 small nuclear RNA auxiliary factor 1
ZDHHC11 zinc finger, DHHC-type containing 11

decreased expression

Symbol Name
ADAMDEC1 ADAM-like, decysin 1
AHNAK2 AHNAK nucleoprotein 2
AHR aryl hydrocarbon receptor
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ARMCX2 armadillo repeat containing, X-linked 2
ATAD2 ATPase family, AAA domain containing 2
B3GNT1
BPHL biphenyl hydrolase-like (serine hydrolase)
CCNE2 cyclin E2
CD24 CD24 molecule
CDCA4 cell division cycle associated 4
CDK1 cyclin-dependent kinase 1
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CFB complement factor B
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHN1 chimerin 1
CHN2 chimerin 2
COL3A1 collagen, type III, alpha 1
COPS7A COP9 signalosome subunit 7A
CPD carboxypeptidase D
CPE carboxypeptidase E
CRABP1 cellular retinoic acid binding protein 1
CXADR coxsackie virus and adenovirus receptor
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL11 chemokine (C-X-C motif) ligand 11
CXCL9 chemokine (C-X-C motif) ligand 9
DSP desmoplakin
ECT2 epithelial cell transforming 2
ENO2 enolase 2 (gamma, neuronal)
ESR1 estrogen receptor 1
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FCGBP Fc fragment of IgG binding protein
FKBP5 FK506 binding protein 5
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
GLUL glutamate-ammonia ligase
GPNMB glycoprotein (transmembrane) nmb
GTPBP8 GTP-binding protein 8 (putative)
GUSBP3 glucuronidase, beta pseudogene 3
H2AFX H2A histone family, member X
HIST1H1C histone cluster 1, H1c
HMGB2 high mobility group box 2
HOXC6 homeobox C6
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IL1R1 interleukin 1 receptor, type I
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KRT15 keratin 15, type I
KRT2 keratin 2, type II
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
LXN latexin
LYZ lysozyme
MAB21L2 mab-21-like 2 (C. elegans)
MAOA monoamine oxidase A
MAPT microtubule-associated protein tau
METTL7A methyltransferase like 7A
MKI67 marker of proliferation Ki-67
MMP12 matrix metallopeptidase 12
NR4A2 nuclear receptor subfamily 4, group A, member 2
NUSAP1 nucleolar and spindle associated protein 1
PACSIN3 protein kinase C and casein kinase substrate in neurons 3
PBK PDZ binding kinase
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
POLQ polymerase (DNA directed), theta
RAB31 RAB31, member RAS oncogene family
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RELN reelin
RNASE4 ribonuclease, RNase A family, 4
S100A14 S100 calcium binding protein A14
SCGB1D2 secretoglobin, family 1D, member 2
SEPP1 selenoprotein P, plasma, 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINB4 serpin peptidase inhibitor, clade B (ovalbumin), member 4
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3
SRGN serglycin
SST somatostatin
ST6GALNAC5 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
STAT1 signal transducer and activator of transcription 1, 91kDa
STC2 stanniocalcin 2
SYBU syntabulin (syntaxin-interacting)
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TMEM176B transmembrane protein 176B
TOP2A topoisomerase (DNA) II alpha 170kDa
UBA6 ubiquitin-like modifier activating enzyme 6
UBE2C ubiquitin-conjugating enzyme E2C
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
VEGFA vascular endothelial growth factor A
WFDC2 WAP four-disulfide core domain 2
XBP1 X-box binding protein 1
XIST X inactive specific transcript (non-protein coding)