BRD-K92428232_GSK-461364_HT29_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

92 genes differentially expressed following the BRD-K92428232_GSK-461364_HT29_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AFP alpha-fetoprotein
AMDHD2 amidohydrolase domain containing 2
AMIGO2 adhesion molecule with Ig-like domain 2
ATF3 activating transcription factor 3
BZW2 basic leucine zipper and W2 domains 2
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CLU clusterin
CNPY3 canopy FGF signaling regulator 3
CYR61 cysteine-rich, angiogenic inducer, 61
DAXX death-domain associated protein
DHCR24 24-dehydrocholesterol reductase
DLK1 delta-like 1 homolog (Drosophila)
EGR1 early growth response 1
EGR3 early growth response 3
FCMR Fc fragment of IgM receptor
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSL1 FOS-like antigen 1
FTH1 ferritin, heavy polypeptide 1
GDF15 growth differentiation factor 15
HEPH hephaestin
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HOOK2 hook microtubule-tethering protein 2
INSIG1 insulin induced gene 1
KYNU kynureninase
LDLR low density lipoprotein receptor
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAST4 microtubule associated serine/threonine kinase family member 4
MSMO1 methylsterol monooxygenase 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
OSBPL3 oxysterol binding protein-like 3
PDGFD platelet derived growth factor D
PDZK1IP1 PDZK1 interacting protein 1
PFKP phosphofructokinase, platelet
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLA2G16 phospholipase A2, group XVI
PLK2 polo-like kinase 2
PRDX2 peroxiredoxin 2
RAP1GAP RAP1 GTPase activating protein
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SDC4 syndecan 4
SEPT9 septin 9
SLC43A3 solute carrier family 43, member 3
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SNX10 sorting nexin 10
SQSTM1 sequestosome 1
TFF1 trefoil factor 1
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TM4SF1 transmembrane 4 L six family member 1
TRAC T cell receptor alpha constant
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
CD93 CD93 molecule
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CDK1 cyclin-dependent kinase 1
CENPA centromere protein A
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CXCL12 chemokine (C-X-C motif) ligand 12
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EIF4B eukaryotic translation initiation factor 4B
EXOSC4 exosome component 4
FCN1 ficolin (collagen/fibrinogen domain containing) 1
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GTPBP8 GTP-binding protein 8 (putative)
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
KIF11 kinesin family member 11
KIF20A kinesin family member 20A
LST1 leukocyte specific transcript 1
LYPLA1 lysophospholipase I
MN1 meningioma (disrupted in balanced translocation) 1
MOXD1 monooxygenase, DBH-like 1
MSH6 mutS homolog 6
NDNF neuron-derived neurotrophic factor
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NLRP2 NLR family, pyrin domain containing 2
NR2F2 nuclear receptor subfamily 2, group F, member 2
NUSAP1 nucleolar and spindle associated protein 1
PLEKHA5 pleckstrin homology domain containing, family A member 5
PRAME preferentially expressed antigen in melanoma
PXMP2 peroxisomal membrane protein 2, 22kDa
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
SRGN serglycin
TFPI2 tissue factor pathway inhibitor 2
TMEM45A transmembrane protein 45A
TMPO thymopoietin
TMSB15A thymosin beta 15a
TOP2A topoisomerase (DNA) II alpha 170kDa
UBE2A ubiquitin-conjugating enzyme E2A
UBE2C ubiquitin-conjugating enzyme E2C
WNT5A wingless-type MMTV integration site family, member 5A