BRD-K92428232_GSK-461364_HEPG2_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

88 genes differentially expressed following the BRD-K92428232_GSK-461364_HEPG2_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACLY ATP citrate lyase
AIM1 absent in melanoma 1
ALOX15B arachidonate 15-lipoxygenase, type B
AUTS2 autism susceptibility candidate 2
BAG3 BCL2-associated athanogene 3
CCND2 cyclin D2
CD24 CD24 molecule
COCH cochlin
DHCR24 24-dehydrocholesterol reductase
FGF13 fibroblast growth factor 13
GPRC5B G protein-coupled receptor, class C, group 5, member B
GRB10 growth factor receptor-bound protein 10
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSPA1A heat shock 70kDa protein 1A
INPP5D inositol polyphosphate-5-phosphatase, 145kDa
KLHDC10 kelch domain containing 10
KYNU kynureninase
MFSD10 major facilitator superfamily domain containing 10
PALLD palladin, cytoskeletal associated protein
PDZK1IP1 PDZK1 interacting protein 1
PFKP phosphofructokinase, platelet
PRSS2 protease, serine, 2 (trypsin 2)
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SLC43A3 solute carrier family 43, member 3
SLC44A4 solute carrier family 44, member 4
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2
TM4SF1 transmembrane 4 L six family member 1
TSPAN8 tetraspanin 8
VAMP8 vesicle-associated membrane protein 8
VDAC1 voltage-dependent anion channel 1
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADAM12 ADAM metallopeptidase domain 12
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AHR aryl hydrocarbon receptor
ANGPT1 angiopoietin 1
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CD14 CD14 molecule
CD200 CD200 molecule
CDK1 cyclin-dependent kinase 1
CKAP4 cytoskeleton-associated protein 4
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
COL6A3 collagen, type VI, alpha 3
CPNE3 copine III
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL9 chemokine (C-X-C motif) ligand 9
CYP4F3 cytochrome P450, family 4, subfamily F, polypeptide 3
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
EMP1 epithelial membrane protein 1
FZD6 frizzled class receptor 6
G0S2 G0/G1 switch 2
GATA3 GATA binding protein 3
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GTPBP8 GTP-binding protein 8 (putative)
HBB hemoglobin, beta
HBD hemoglobin, delta
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HSPA13 heat shock protein 70kDa family, member 13
IFI6 interferon, alpha-inducible protein 6
IFITM1 interferon induced transmembrane protein 1
IGKC immunoglobulin kappa constant
IGKV4-1 immunoglobulin kappa variable 4-1
IGL immunoglobulin lambda locus
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
LPAR1 lysophosphatidic acid receptor 1
LRRC17 leucine rich repeat containing 17
MMP9 matrix metallopeptidase 9
MX1 MX dynamin-like GTPase 1
NID1 nidogen 1
NOTCH3 notch 3
PACSIN3 protein kinase C and casein kinase substrate in neurons 3
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PLBD1 phospholipase B domain containing 1
POSTN periostin, osteoblast specific factor
PPAP2B phosphatidic acid phosphatase type 2B
RNASE4 ribonuclease, RNase A family, 4
RTN1 reticulon 1
SCGB2A1 secretoglobin, family 2A, member 1
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4
TOP2A topoisomerase (DNA) II alpha 170kDa
TRD T cell receptor delta locus
TRDV3 T cell receptor delta variable 3
UBE2C ubiquitin-conjugating enzyme E2C
WNT5A wingless-type MMTV integration site family, member 5A