BRD-K92428232_GSK-461364_HEPG2_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

107 genes differentially expressed following the BRD-K92428232_GSK-461364_HEPG2_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ALCAM activated leukocyte cell adhesion molecule
ANXA1 annexin A1
BAG3 BCL2-associated athanogene 3
BAX BCL2-associated X protein
BZW2 basic leucine zipper and W2 domains 2
CLDN18 claudin 18
CLEC2B C-type lectin domain family 2, member B
COLEC12 collectin sub-family member 12
CXCR4 chemokine (C-X-C motif) receptor 4
CYR61 cysteine-rich, angiogenic inducer, 61
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42
DKK3 dickkopf WNT signaling pathway inhibitor 3
DLC1 DLC1 Rho GTPase activating protein
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6
FASTKD5 FAST kinase domains 5
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FOSL1 FOS-like antigen 1
GADD45B growth arrest and DNA-damage-inducible, beta
GLIPR1 GLI pathogenesis-related 1
HOPX HOP homeobox
IGFBP7 insulin-like growth factor binding protein 7
LAMC2 laminin, gamma 2
MT1E metallothionein 1E
MT1F metallothionein 1F
NDRG4 NDRG family member 4
PFKP phosphofructokinase, platelet
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
RBM34 RNA binding motif protein 34
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RPS11 ribosomal protein S11
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SQSTM1 sequestosome 1
TM4SF1 transmembrane 4 L six family member 1
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1

decreased expression

Symbol Name
ADD3 adducin 3 (gamma)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
ALOX5 arachidonate 5-lipoxygenase
ARG1 arginase 1
CD200 CD200 molecule
CD24 CD24 molecule
CD9 CD9 molecule
CDK1 cyclin-dependent kinase 1
CFD complement factor D (adipsin)
CKAP4 cytoskeleton-associated protein 4
COBLL1 cordon-bleu WH2 repeat protein-like 1
COL15A1 collagen, type XV, alpha 1
COL1A2 collagen, type I, alpha 2
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL9 chemokine (C-X-C motif) ligand 9
DEFB1 defensin, beta 1
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DNTT DNA nucleotidylexotransferase
DPT dermatopontin
DSP desmoplakin
DUSP2 dual specificity phosphatase 2
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FGB fibrinogen beta chain
FGG fibrinogen gamma chain
GLUL glutamate-ammonia ligase
HBB hemoglobin, beta
HMGB2 high mobility group box 2
HPN hepsin
IGFBP5 insulin-like growth factor binding protein 5
IGHM immunoglobulin heavy constant mu
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KNG1 kininogen 1
MAMLD1 mastermind-like domain containing 1
MAN1A1 mannosidase, alpha, class 1A, member 1
MAP2K6 mitogen-activated protein kinase kinase 6
MB myoglobin
MSMO1 methylsterol monooxygenase 1
MXI1 MAX interactor 1, dimerization protein
MXRA5 matrix-remodelling associated 5
NUSAP1 nucleolar and spindle associated protein 1
OSR2 odd-skipped related transciption factor 2
PACSIN3 protein kinase C and casein kinase substrate in neurons 3
PAH phenylalanine hydroxylase
PCOLCE2 procollagen C-endopeptidase enhancer 2
PCP4 Purkinje cell protein 4
PDGFRL platelet-derived growth factor receptor-like
PON3 paraoxonase 3
PPAP2B phosphatidic acid phosphatase type 2B
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PXMP2 peroxisomal membrane protein 2, 22kDa
RNASE4 ribonuclease, RNase A family, 4
S100P S100 calcium binding protein P
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SDC2 syndecan 2
SERPINA6 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6
SGMS1 sphingomyelin synthase 1
SGPP1 sphingosine-1-phosphate phosphatase 1
SPTSSA serine palmitoyltransferase, small subunit A
STAT1 signal transducer and activator of transcription 1, 91kDa
TMED2 transmembrane emp24 domain trafficking protein 2
TOP2A topoisomerase (DNA) II alpha 170kDa
TTN titin
UBE2C ubiquitin-conjugating enzyme E2C
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
UGDH UDP-glucose 6-dehydrogenase
XBP1 X-box binding protein 1