BRD-K92428232_GSK-461364_HCC515_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

84 genes differentially expressed following the BRD-K92428232_GSK-461364_HCC515_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ANXA1 annexin A1
AURKA aurora kinase A
BIRC5 baculoviral IAP repeat containing 5
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CCNB1 cyclin B1
CCT6A chaperonin containing TCP1, subunit 6A (zeta 1)
CDC25B cell division cycle 25B
CDCA8 cell division cycle associated 8
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDKN3 cyclin-dependent kinase inhibitor 3
COL2A1 collagen, type II, alpha 1
CTSD cathepsin D
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
ESPL1 extra spindle pole bodies homolog 1 (S. cerevisiae)
FSCN1 fascin actin-bundling protein 1
H2AFV H2A histone family, member V
HIST1H2AC histone cluster 1, H2ac
HK1 hexokinase 1
KIF20A kinesin family member 20A
KLK10 kallikrein-related peptidase 10
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
KRT23 keratin 23, type I
LAMP3 lysosomal-associated membrane protein 3
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LTBP1 latent transforming growth factor beta binding protein 1
LYZ lysozyme
MELK maternal embryonic leucine zipper kinase
MFAP5 microfibrillar associated protein 5
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NDC80 NDC80 kinetochore complex component
NUP62 nucleoporin 62kDa
PLK1 polo-like kinase 1
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1
TPX2 TPX2, microtubule-associated
TRPS1 trichorhinophalangeal syndrome I
WT1 Wilms tumor 1
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)

decreased expression

Symbol Name
ADCK3 aarF domain containing kinase 3
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ANXA3 annexin A3
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BASP1 brain abundant, membrane attached signal protein 1
BLNK B-cell linker
C8ORF4 chromosome 8 open reading frame 4
CASP7 caspase 7, apoptosis-related cysteine peptidase
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
CLU clusterin
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL6 chemokine (C-X-C motif) ligand 6
DNMBP dynamin binding protein
DST dystonin
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)
GALNT14 polypeptide N-acetylgalactosaminyltransferase 14
GATA3 GATA binding protein 3
GPM6B glycoprotein M6B
GPX1 glutathione peroxidase 1
GSTP1 glutathione S-transferase pi 1
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
IGHM immunoglobulin heavy constant mu
JCHAIN joining chain of multimeric IgA and IgM
KIAA1033 KIAA1033
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
LSP1 lymphocyte-specific protein 1
ME2 malic enzyme 2, NAD(+)-dependent, mitochondrial
MYC v-myc avian myelocytomatosis viral oncogene homolog
NAMPT nicotinamide phosphoribosyltransferase
NPTX2 neuronal pentraxin II
PCNA proliferating cell nuclear antigen
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
PSD3 pleckstrin and Sec7 domain containing 3
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RGS5 regulator of G-protein signaling 5
S100A9 S100 calcium binding protein A9
SLC15A2 solute carrier family 15 (oligopeptide transporter), member 2
SPINK1 serine peptidase inhibitor, Kazal type 1
SPTBN1 spectrin, beta, non-erythrocytic 1
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10