BRD-K92428232_GSK-461364_HA1E_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
Similar Terms
Downloads & Tools

Genes

183 genes differentially expressed following the BRD-K92428232_GSK-461364_HA1E_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ACAA1 acetyl-CoA acyltransferase 1
ACACB acetyl-CoA carboxylase beta
ACSL5 acyl-CoA synthetase long-chain family member 5
ADD3 adducin 3 (gamma)
AKAP8L A kinase (PRKA) anchor protein 8-like
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
AURKA aurora kinase A
BCHE butyrylcholinesterase
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
CHL1 cell adhesion molecule L1-like
CLEC2B C-type lectin domain family 2, member B
COCH cochlin
COL15A1 collagen, type XV, alpha 1
COX11 COX11 cytochrome c oxidase copper chaperone
EDNRB endothelin receptor type B
EIF5B eukaryotic translation initiation factor 5B
EPHB2 EPH receptor B2
ERAP2 endoplasmic reticulum aminopeptidase 2
FABP4 fatty acid binding protein 4, adipocyte
FAM171A1 family with sequence similarity 171, member A1
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
HIST1H2AC histone cluster 1, H2ac
HIST1H2BC histone cluster 1, H2bc
HIST1H2BH histone cluster 1, H2bh
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
HOXB7 homeobox B7
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IGKV1-5 immunoglobulin kappa variable 1-5
IMPA1 inositol(myo)-1(or 4)-monophosphatase 1
IQGAP2 IQ motif containing GTPase activating protein 2
JADE2 jade family PHD finger 2
KIF14 kinesin family member 14
LCN2 lipocalin 2
LIMS1 LIM and senescent cell antigen-like domains 1
LYPD1 LY6/PLAUR domain containing 1
MALT1 MALT1 paracaspase
MERTK MER proto-oncogene, tyrosine kinase
METTL5 methyltransferase like 5
MPPED2 metallophosphoesterase domain containing 2
MTA1 metastasis associated 1
NAAA N-acylethanolamine acid amidase
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NSA2 NSA2 ribosome biogenesis homolog (S. cerevisiae)
NT5E 5'-nucleotidase, ecto (CD73)
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PCDH9 protocadherin 9
PDLIM5 PDZ and LIM domain 5
PFDN4 prefoldin subunit 4
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1)
PSMD4 proteasome (prosome, macropain) 26S subunit, non-ATPase, 4
REEP5 receptor accessory protein 5
RPS11 ribosomal protein S11
S100A7 S100 calcium binding protein A7
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SEC62 SEC62 homolog (S. cerevisiae)
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SORBS1 sorbin and SH3 domain containing 1
SOX9 SRY (sex determining region Y)-box 9
SRP72 signal recognition particle 72kDa
STEAP1 six transmembrane epithelial antigen of the prostate 1
TARS threonyl-tRNA synthetase
TCF4 transcription factor 4
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TWF1 twinfilin actin binding protein 1
VCAN versican
VDAC1 voltage-dependent anion channel 1
WSB2 WD repeat and SOCS box containing 2
ZMYND8 zinc finger, MYND-type containing 8
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ADM adrenomedullin
AHNAK2 AHNAK nucleoprotein 2
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)
AKR7A3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase)
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ASCL1 achaete-scute family bHLH transcription factor 1
ATF3 activating transcription factor 3
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BANF1 barrier to autointegration factor 1
BTG1 B-cell translocation gene 1, anti-proliferative
BTG2 BTG family, member 2
C10ORF10 chromosome 10 open reading frame 10
CA9 carbonic anhydrase IX
CADM1 cell adhesion molecule 1
CCL19 chemokine (C-C motif) ligand 19
CCL2 chemokine (C-C motif) ligand 2
CCNE2 cyclin E2
CDCA4 cell division cycle associated 4
CDK1 cyclin-dependent kinase 1
CETN2 centrin, EF-hand protein, 2
CFD complement factor D (adipsin)
CLIC3 chloride intracellular channel 3
CLU clusterin
COPS7A COP9 signalosome subunit 7A
CREG1 cellular repressor of E1A-stimulated genes 1
CYB5A cytochrome b5 type A (microsomal)
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DRAM1 DNA-damage regulated autophagy modulator 1
DUSP5 dual specificity phosphatase 5
ENO2 enolase 2 (gamma, neuronal)
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
FABP7 fatty acid binding protein 7, brain
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)
FOXJ3 forkhead box J3
FRY furry homolog (Drosophila)
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GADD45B growth arrest and DNA-damage-inducible, beta
GLUL glutamate-ammonia ligase
GPNMB glycoprotein (transmembrane) nmb
HILPDA hypoxia inducible lipid droplet-associated
HLA-G major histocompatibility complex, class I, G
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HOPX HOP homeobox
HSPA2 heat shock 70kDa protein 2
IER3 immediate early response 3
IFITM1 interferon induced transmembrane protein 1
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP5 insulin-like growth factor binding protein 5
IL32 interleukin 32
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
INSIG1 insulin induced gene 1
IRF9 interferon regulatory factor 9
JUN jun proto-oncogene
KDM5D lysine (K)-specific demethylase 5D
KLF10 Kruppel-like factor 10
KLHDC2 kelch domain containing 2
KLHL21 kelch-like family member 21
KRT7 keratin 7, type II
LGALS3 lectin, galactoside-binding, soluble, 3
LITAF lipopolysaccharide-induced TNF factor
LMCD1 LIM and cysteine-rich domains 1
LPCAT1 lysophosphatidylcholine acyltransferase 1
LUM lumican
LYZ lysozyme
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MBP myelin basic protein
MCM5 minichromosome maintenance complex component 5
MSMB microseminoprotein, beta-
MYC v-myc avian myelocytomatosis viral oncogene homolog
NAV2 neuron navigator 2
NDRG1 N-myc downstream regulated 1
NEFL neurofilament, light polypeptide
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NISCH nischarin
NR2F2 nuclear receptor subfamily 2, group F, member 2
NREP neuronal regeneration related protein
NUPR1 nuclear protein, transcriptional regulator, 1
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PCBP2 poly(rC) binding protein 2
PGD phosphogluconate dehydrogenase
PIM1 Pim-1 proto-oncogene, serine/threonine kinase
PPL periplakin
PPP1R3C protein phosphatase 1, regulatory subunit 3C
RNASE4 ribonuclease, RNase A family, 4
RPS4Y1 ribosomal protein S4, Y-linked 1
RTN2 reticulon 2
S100A11 S100 calcium binding protein A11
S100A8 S100 calcium binding protein A8
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SFN stratifin
SIK1 salt-inducible kinase 1
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SOX4 SRY (sex determining region Y)-box 4
SPAG4 sperm associated antigen 4
STAT1 signal transducer and activator of transcription 1, 91kDa
SULF1 sulfatase 1
TACC2 transforming, acidic coiled-coil containing protein 2
TACSTD2 tumor-associated calcium signal transducer 2
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TMEM45A transmembrane protein 45A
TOPBP1 topoisomerase (DNA) II binding protein 1
TPM2 tropomyosin 2 (beta)
TRDV3 T cell receptor delta variable 3
TXNIP thioredoxin interacting protein
WEE1 WEE1 G2 checkpoint kinase
ZFP36L2 ZFP36 ring finger protein-like 2