BRD-K92428232_GSK-461364_A549_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

54 genes differentially expressed following the BRD-K92428232_GSK-461364_A549_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AURKA aurora kinase A
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CX3CR1 chemokine (C-X3-C motif) receptor 1
CYTL1 cytokine-like 1
EGR1 early growth response 1
GNAS GNAS complex locus
HMG20B high mobility group 20B
JMJD6 jumonji domain containing 6
PDIA5 protein disulfide isomerase family A, member 5
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
TGFBI transforming growth factor, beta-induced, 68kDa
TMEM158 transmembrane protein 158 (gene/pseudogene)
WT1 Wilms tumor 1

decreased expression

Symbol Name
AGR2 anterior gradient 2
AKR1C3 aldo-keto reductase family 1, member C3
ANK2 ankyrin 2, neuronal
CALD1 caldesmon 1
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CCNF cyclin F
CDCA4 cell division cycle associated 4
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CDK1 cyclin-dependent kinase 1
CLU clusterin
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CRIP1 cysteine-rich protein 1 (intestinal)
DCN decorin
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
FBP1 fructose-1,6-bisphosphatase 1
FGG fibrinogen gamma chain
GULP1 GULP, engulfment adaptor PTB domain containing 1
HES1 hes family bHLH transcription factor 1
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
LAMP5 lysosomal-associated membrane protein family, member 5
MDK midkine (neurite growth-promoting factor 2)
MGP matrix Gla protein
NET1 neuroepithelial cell transforming 1
RAD51AP1 RAD51 associated protein 1
RNASE4 ribonuclease, RNase A family, 4
RRM2 ribonucleotide reductase M2
SNAP25 synaptosomal-associated protein, 25kDa
STMN2 stathmin 2
SYT1 synaptotagmin I
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TOP2A topoisomerase (DNA) II alpha 170kDa
UBE2A ubiquitin-conjugating enzyme E2A
UBE2C ubiquitin-conjugating enzyme E2C
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
WWTR1 WW domain containing transcription regulator 1
ZDHHC6 zinc finger, DHHC-type containing 6
ZWINT ZW10 interacting kinetochore protein