BRD-K92428232_GSK-461364_A375_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
Similar Terms
Downloads & Tools

Genes

149 genes differentially expressed following the BRD-K92428232_GSK-461364_A375_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD2 abhydrolase domain containing 2
ACTN1 actinin, alpha 1
AGTR1 angiotensin II receptor, type 1
AKAP8L A kinase (PRKA) anchor protein 8-like
ANKRD27 ankyrin repeat domain 27 (VPS9 domain)
ANPEP alanyl (membrane) aminopeptidase
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
AZU1 azurocidin 1
CCND2 cyclin D2
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CFB complement factor B
CLC Charcot-Leyden crystal galectin
COCH cochlin
CSRP2 cysteine and glycine-rich protein 2
CTSW cathepsin W
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL8 chemokine (C-X-C motif) ligand 8
CYR61 cysteine-rich, angiogenic inducer, 61
DHRS2 dehydrogenase/reductase (SDR family) member 2
EGR1 early growth response 1
EGR2 early growth response 2
ELANE elastase, neutrophil expressed
ELF1 E74-like factor 1 (ets domain transcription factor)
FOS FBJ murine osteosarcoma viral oncogene homolog
GADD45A growth arrest and DNA-damage-inducible, alpha
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
GLUL glutamate-ammonia ligase
H2BFS H2B histone family, member S (pseudogene)
HBEGF heparin-binding EGF-like growth factor
HIST1H2AC histone cluster 1, H2ac
HIST1H2BC histone cluster 1, H2bc
HIST1H2BD histone cluster 1, H2bd
HIST1H2BE histone cluster 1, H2be
HIST1H2BF histone cluster 1, H2bf
HIST1H2BG histone cluster 1, H2bg
HIST1H2BH histone cluster 1, H2bh
HIST1H2BK histone cluster 1, H2bk
HNMT histamine N-methyltransferase
HOMER1 homer scaffolding protein 1
HSPB8 heat shock 22kDa protein 8
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IL1RN interleukin 1 receptor antagonist
KCTD5 potassium channel tetramerization domain containing 5
KLHDC10 kelch domain containing 10
LCN2 lipocalin 2
LRRC59 leucine rich repeat containing 59
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
LTF lactotransferrin
MEIS2 Meis homeobox 2
MMP7 matrix metallopeptidase 7
MMP9 matrix metallopeptidase 9
MSRA methionine sulfoxide reductase A
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MT1X metallothionein 1X
NFE2L2 nuclear factor, erythroid 2-like 2
NOP16 NOP16 nucleolar protein
NR4A3 nuclear receptor subfamily 4, group A, member 3
OLFM4 olfactomedin 4
PARP8 poly (ADP-ribose) polymerase family, member 8
PRSS2 protease, serine, 2 (trypsin 2)
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RBM25 RNA binding motif protein 25
REG1A regenerating islet-derived 1 alpha
SDC2 syndecan 2
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SPINK1 serine peptidase inhibitor, Kazal type 1
SPON1 spondin 1, extracellular matrix protein
STAT1 signal transducer and activator of transcription 1, 91kDa
STK38L serine/threonine kinase 38 like
TARP TCR gamma alternate reading frame protein
TCL1A T-cell leukemia/lymphoma 1A
TPM1 tropomyosin 1 (alpha)
VDAC1 voltage-dependent anion channel 1
ZEB2 zinc finger E-box binding homeobox 2
ZMAT3 zinc finger, matrin-type 3

decreased expression

Symbol Name
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AKR1C3 aldo-keto reductase family 1, member C3
ALDOC aldolase C, fructose-bisphosphate
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
BTBD3 BTB (POZ) domain containing 3
CADM1 cell adhesion molecule 1
CALR calreticulin
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CAPN3 calpain 3, (p94)
CCNE2 cyclin E2
CCNF cyclin F
CD59 CD59 molecule, complement regulatory protein
CDCA4 cell division cycle associated 4
CDK1 cyclin-dependent kinase 1
CKAP4 cytoskeleton-associated protein 4
CLEC7A C-type lectin domain family 7, member A
COL6A1 collagen, type VI, alpha 1
EFNA1 ephrin-A1
ENO2 enolase 2 (gamma, neuronal)
F2RL1 coagulation factor II (thrombin) receptor-like 1
FN1 fibronectin 1
GINS1 GINS complex subunit 1 (Psf1 homolog)
HELLS helicase, lymphoid-specific
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HLA-DRA major histocompatibility complex, class II, DR alpha
HSPA1A heat shock 70kDa protein 1A
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
MAP1B microtubule-associated protein 1B
MBP myelin basic protein
METRN meteorin, glial cell differentiation regulator
NAV2 neuron navigator 2
NISCH nischarin
NLRP2 NLR family, pyrin domain containing 2
NUSAP1 nucleolar and spindle associated protein 1
NVL nuclear VCP-like
OPHN1 oligophrenin 1
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PACSIN3 protein kinase C and casein kinase substrate in neurons 3
PLIN2 perilipin 2
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PSPH phosphoserine phosphatase
RPL27A ribosomal protein L27a
RPL37A ribosomal protein L37a
RPL38 ribosomal protein L38
RPS11 ribosomal protein S11
RRM2 ribonucleotide reductase M2
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A2 secretoglobin, family 2A, member 2
SEPP1 selenoprotein P, plasma, 1
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
STATH statherin
SVIL supervillin
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TOP2A topoisomerase (DNA) II alpha 170kDa
TUBB2A tubulin, beta 2A class IIa
UBE2A ubiquitin-conjugating enzyme E2A
UBE2C ubiquitin-conjugating enzyme E2C
UGP2 UDP-glucose pyrophosphorylase 2
WEE1 WEE1 G2 checkpoint kinase
WNT5A wingless-type MMTV integration site family, member 5A
ZBTB18 zinc finger and BTB domain containing 18
ZNF589 zinc finger protein 589
ZSCAN18 zinc finger and SCAN domain containing 18