BRD-K92317137_-666_THP1_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

310 genes differentially expressed following the BRD-K92317137_-666_THP1_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADIRF adipogenesis regulatory factor
ADM adrenomedullin
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ALDOC aldolase C, fructose-bisphosphate
ANPEP alanyl (membrane) aminopeptidase
AQP9 aquaporin 9
AREG amphiregulin
ATF3 activating transcription factor 3
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
AVPI1 arginine vasopressin-induced 1
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BAG3 BCL2-associated athanogene 3
BCL2A1 BCL2-related protein A1
BCL3 B-cell CLL/lymphoma 3
BHLHE40 basic helix-loop-helix family, member e40
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BPGM 2,3-bisphosphoglycerate mutase
BTG1 B-cell translocation gene 1, anti-proliferative
C5AR1 complement component 5a receptor 1
CCL4 chemokine (C-C motif) ligand 4
CCNG2 cyclin G2
CD14 CD14 molecule
CD163 CD163 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHMP1B charged multivesicular body protein 1B
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLEC2B C-type lectin domain family 2, member B
CLIC4 chloride intracellular channel 4
COL6A2 collagen, type VI, alpha 2
CORO1C coronin, actin binding protein, 1C
CSRP1 cysteine and glycine-rich protein 1
CTH cystathionine gamma-lyase
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL8 chemokine (C-X-C motif) ligand 8
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DLX2 distal-less homeobox 2
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DUSP1 dual specificity phosphatase 1
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
EFNB2 ephrin-B2
EGLN3 egl-9 family hypoxia-inducible factor 3
EIF1 eukaryotic translation initiation factor 1
EMP1 epithelial membrane protein 1
ERO1L ERO1-like (S. cerevisiae)
F2RL1 coagulation factor II (thrombin) receptor-like 1
FAM13A family with sequence similarity 13, member A
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
FOSL2 FOS-like antigen 2
FOXO3 forkhead box O3
FTH1 ferritin, heavy polypeptide 1
FYN FYN proto-oncogene, Src family tyrosine kinase
G0S2 G0/G1 switch 2
GABARAPL1 GABA(A) receptor-associated protein like 1
GDF15 growth differentiation factor 15
GLRX glutaredoxin (thioltransferase)
GLUL glutamate-ammonia ligase
GPR137B G protein-coupled receptor 137B
H2BFS H2B histone family, member S (pseudogene)
HBB hemoglobin, beta
HBEGF heparin-binding EGF-like growth factor
HBP1 HMG-box transcription factor 1
HCAR3 hydroxycarboxylic acid receptor 3
HILPDA hypoxia inducible lipid droplet-associated
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BC histone cluster 1, H2bc
HIST1H2BK histone cluster 1, H2bk
HK2 hexokinase 2
HMOX1 heme oxygenase 1
HSPA13 heat shock protein 70kDa family, member 13
HSPA1A heat shock 70kDa protein 1A
HSPA2 heat shock 70kDa protein 2
HSPA6 heat shock 70kDa protein 6 (HSP70B')
ICAM1 intercellular adhesion molecule 1
IER3 immediate early response 3
IFI27 interferon, alpha-inducible protein 27
IFI30 interferon, gamma-inducible protein 30
IL1B interleukin 1, beta
IL6 interleukin 6
INSIG1 insulin induced gene 1
IRF7 interferon regulatory factor 7
JMJD1C jumonji domain containing 1C
JUN jun proto-oncogene
KDM3A lysine (K)-specific demethylase 3A
KLF2 Kruppel-like factor 2
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
KLHL24 kelch-like family member 24
KRT17 keratin 17, type I
LAMP2 lysosomal-associated membrane protein 2
LDLR low density lipoprotein receptor
LGALS8 lectin, galactoside-binding, soluble, 8
LRP12 low density lipoprotein receptor-related protein 12
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MBOAT7 membrane bound O-acyltransferase domain containing 7
MCL1 myeloid cell leukemia 1
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MGAM maltase-glucoamylase
MIR22HG MIR22 host gene
MKRN1 makorin ring finger protein 1
MORC4 MORC family CW-type zinc finger 4
MT1F metallothionein 1F
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MT1M metallothionein 1M
MT1X metallothionein 1X
MT2A metallothionein 2A
MXI1 MAX interactor 1, dimerization protein
MYO1B myosin IB
NAMPT nicotinamide phosphoribosyltransferase
NDRG1 N-myc downstream regulated 1
NEU1 sialidase 1 (lysosomal sialidase)
NFIL3 nuclear factor, interleukin 3 regulated
NINJ1 ninjurin 1
NKX3-1 NK3 homeobox 1
NQO2 NAD(P)H dehydrogenase, quinone 2
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NRBF2 nuclear receptor binding factor 2
NRN1 neuritin 1
NUPL1 nucleoporin like 1
OASL 2'-5'-oligoadenylate synthetase-like
OSER1 oxidative stress responsive serine-rich 1
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PDE4B phosphodiesterase 4B, cAMP-specific
PDGFA platelet-derived growth factor alpha polypeptide
PELI1 pellino E3 ubiquitin protein ligase 1
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PGK1 phosphoglycerate kinase 1
PHIP pleckstrin homology domain interacting protein
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAUR plasminogen activator, urokinase receptor
PLIN2 perilipin 2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPARG peroxisome proliferator-activated receptor gamma
PPM1A protein phosphatase, Mg2+/Mn2+ dependent, 1A
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PSAP prosaposin
PTP4A1 protein tyrosine phosphatase type IVA, member 1
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
RGCC regulator of cell cycle
RGS2 regulator of G-protein signaling 2
RHOB ras homolog family member B
RIOK3 RIO kinase 3
S100P S100 calcium binding protein P
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SCGB2A2 secretoglobin, family 2A, member 2
SDC4 syndecan 4
SEC24A SEC24 family member A
SERINC1 serine incorporator 1
SGK1 serum/glucocorticoid regulated kinase 1
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMOX spermine oxidase
SMPDL3A sphingomyelin phosphodiesterase, acid-like 3A
SNAI2 snail family zinc finger 2
SOD2 superoxide dismutase 2, mitochondrial
SPARCL1 SPARC-like 1 (hevin)
SPRY4 sprouty homolog 4 (Drosophila)
SQSTM1 sequestosome 1
SSFA2 sperm specific antigen 2
STC1 stanniocalcin 1
STC2 stanniocalcin 2
TBX3 T-box 3
TERF2IP telomeric repeat binding factor 2, interacting protein
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGFBI transforming growth factor, beta-induced, 68kDa
TICAM1 toll-like receptor adaptor molecule 1
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM45A transmembrane protein 45A
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TREM1 triggering receptor expressed on myeloid cells 1
TRIB1 tribbles pseudokinase 1
TRIB3 tribbles pseudokinase 3
TSC22D1 TSC22 domain family, member 1
TSC22D3 TSC22 domain family, member 3
TUBB2A tubulin, beta 2A class IIa
TUFT1 tuftelin 1
UBAP1 ubiquitin associated protein 1
VEGFA vascular endothelial growth factor A
WIPF2 WAS/WASL interacting protein family, member 2
WIPI1 WD repeat domain, phosphoinositide interacting 1
WSB1 WD repeat and SOCS box containing 1
YPEL5 yippee-like 5 (Drosophila)
ZFP36 ZFP36 ring finger protein
ZNF292 zinc finger protein 292

decreased expression

Symbol Name
ACTN1 actinin, alpha 1
ADGRG6 adhesion G protein-coupled receptor G6
AIMP2 aminoacyl tRNA synthetase complex-interacting multifunctional protein 2
AKAP1 A kinase (PRKA) anchor protein 1
ALG8 ALG8, alpha-1,3-glucosyltransferase
BCL2 B-cell CLL/lymphoma 2
C14ORF159 chromosome 14 open reading frame 159
C1QBP complement component 1, q subcomponent binding protein
C3 complement component 3
C7 complement component 7
CAD carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
CCL19 chemokine (C-C motif) ligand 19
CD24 CD24 molecule
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CFB complement factor B
CPM carboxypeptidase M
CTPS1 CTP synthase 1
CXCL13 chemokine (C-X-C motif) ligand 13
DCTPP1 dCTP pyrophosphatase 1
DKC1 dyskeratosis congenita 1, dyskerin
DNPH1 2'-deoxynucleoside 5'-phosphate N-hydrolase 1
DPH2 DPH2 homolog (S. cerevisiae)
EBAG9 estrogen receptor binding site associated, antigen, 9
EIF5A eukaryotic translation initiation factor 5A
EXOSC4 exosome component 4
F13A1 coagulation factor XIII, A1 polypeptide
FAM216A family with sequence similarity 216, member A
FBLN1 fibulin 1
FCER1A Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
FGL1 fibrinogen-like 1
FPGS folylpolyglutamate synthase
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GNL3 guanine nucleotide binding protein-like 3 (nucleolar)
GOLGA8H golgin A8 family, member H
GPD1L glycerol-3-phosphate dehydrogenase 1-like
GREM1 gremlin 1, DAN family BMP antagonist
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IFRD2 interferon-related developmental regulator 2
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
LAMP5 lysosomal-associated membrane protein family, member 5
LPL lipoprotein lipase
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
LY75 lymphocyte antigen 75
MAN1C1 mannosidase, alpha, class 1C, member 1
MEIS1 Meis homeobox 1
METTL7A methyltransferase like 7A
MGAT2 mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
MGST2 microsomal glutathione S-transferase 2
MMP7 matrix metallopeptidase 7
MRPL15 mitochondrial ribosomal protein L15
MRPL3 mitochondrial ribosomal protein L3
MS4A6A membrane-spanning 4-domains, subfamily A, member 6A
MYB v-myb avian myeloblastosis viral oncogene homolog
MYC v-myc avian myelocytomatosis viral oncogene homolog
NARS2 asparaginyl-tRNA synthetase 2, mitochondrial (putative)
NAV2 neuron navigator 2
NME1 NME/NM23 nucleoside diphosphate kinase 1
NOC3L nucleolar complex associated 3 homolog (S. cerevisiae)
NOP16 NOP16 nucleolar protein
NOP56 NOP56 ribonucleoprotein
NREP neuronal regeneration related protein
PA2G4 proliferation-associated 2G4, 38kDa
PARP1 poly (ADP-ribose) polymerase 1
PCP4 Purkinje cell protein 4
PCYOX1L prenylcysteine oxidase 1 like
PEG3 paternally expressed 3
PFAS phosphoribosylformylglycinamidine synthase
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
PLA2G15 phospholipase A2, group XV
PLAC8 placenta-specific 8
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLR1C polymerase (RNA) I polypeptide C, 30kDa
POP5 processing of precursor 5, ribonuclease P/MRP subunit (S. cerevisiae)
PRKCD protein kinase C, delta
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PYCARD PYD and CARD domain containing
RFTN1 raftlin, lipid raft linker 1
RNASE6 ribonuclease, RNase A family, k6
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SCG5 secretogranin V
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SGCE sarcoglycan, epsilon
SLC29A1 solute carrier family 29 (equilibrative nucleoside transporter), member 1
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SRSF1 serine/arginine-rich splicing factor 1
ST5 suppression of tumorigenicity 5
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
STEAP3 STEAP family member 3, metalloreductase
SULF1 sulfatase 1
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TNS3 tensin 3
TRIM14 tripartite motif containing 14
TRIM22 tripartite motif containing 22
TSEN2 TSEN2 tRNA splicing endonuclease subunit
TSPYL5 TSPY-like 5
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
WDR12 WD repeat domain 12
WDR3 WD repeat domain 3
WDR74 WD repeat domain 74
ZFP36L2 ZFP36 ring finger protein-like 2