BRD-K92317137_-666_SW620_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

192 genes differentially expressed following the BRD-K92317137_-666_SW620_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADM adrenomedullin
ADORA2B adenosine A2b receptor
AK4 adenylate kinase 4
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
AMIGO2 adhesion molecule with Ig-like domain 2
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
AXL AXL receptor tyrosine kinase
BHLHE40 basic helix-loop-helix family, member e40
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BTG1 B-cell translocation gene 1, anti-proliferative
C3ORF14 chromosome 3 open reading frame 14
CA2 carbonic anhydrase II
CCND1 cyclin D1
CCNE2 cyclin E2
CD24 CD24 molecule
CD52 CD52 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
COCH cochlin
COL11A1 collagen, type XI, alpha 1
COL5A2 collagen, type V, alpha 2
COL6A1 collagen, type VI, alpha 1
COL6A2 collagen, type VI, alpha 2
COMP cartilage oligomeric matrix protein
CRABP1 cellular retinoic acid binding protein 1
CTSK cathepsin K
CXCL8 chemokine (C-X-C motif) ligand 8
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYR61 cysteine-rich, angiogenic inducer, 61
DCN decorin
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DST dystonin
DUSP1 dual specificity phosphatase 1
DUSP5 dual specificity phosphatase 5
ECM1 extracellular matrix protein 1
EGFR epidermal growth factor receptor
EGR1 early growth response 1
EGR3 early growth response 3
EMP1 epithelial membrane protein 1
FAM129A family with sequence similarity 129, member A
FN1 fibronectin 1
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSL1 FOS-like antigen 1
FXYD5 FXYD domain containing ion transport regulator 5
GARS glycyl-tRNA synthetase
GEM GTP binding protein overexpressed in skeletal muscle
GLS glutaminase
GPNMB glycoprotein (transmembrane) nmb
GPRC5A G protein-coupled receptor, class C, group 5, member A
GREM1 gremlin 1, DAN family BMP antagonist
GULP1 GULP, engulfment adaptor PTB domain containing 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HES1 hes family bHLH transcription factor 1
HILPDA hypoxia inducible lipid droplet-associated
HK2 hexokinase 2
HMOX1 heme oxygenase 1
HPRT1 hypoxanthine phosphoribosyltransferase 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IER3 immediate early response 3
INHBA inhibin, beta A
JAG1 jagged 1
JCHAIN joining chain of multimeric IgA and IgM
JUNB jun B proto-oncogene
KDM3A lysine (K)-specific demethylase 3A
KLF4 Kruppel-like factor 4 (gut)
KRT14 keratin 14, type I
KRT17 keratin 17, type I
KRT6B keratin 6B, type II
LAMB3 laminin, beta 3
LIMCH1 LIM and calponin homology domains 1
LOXL2 lysyl oxidase-like 2
LRRC15 leucine rich repeat containing 15
LY96 lymphocyte antigen 96
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAN1A1 mannosidase, alpha, class 1A, member 1
MLF1 myeloid leukemia factor 1
MMP9 matrix metallopeptidase 9
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1M metallothionein 1M
MT1X metallothionein 1X
MXI1 MAX interactor 1, dimerization protein
MYOF myoferlin
NAMPT nicotinamide phosphoribosyltransferase
NDRG1 N-myc downstream regulated 1
NPTX2 neuronal pentraxin II
NR4A2 nuclear receptor subfamily 4, group A, member 2
OLFM4 olfactomedin 4
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
PENK proenkephalin
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PFKM phosphofructokinase, muscle
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PLXNA1 plexin A1
PPARG peroxisome proliferator-activated receptor gamma
PSD3 pleckstrin and Sec7 domain containing 3
PTPRE protein tyrosine phosphatase, receptor type, E
RND3 Rho family GTPase 3
RNMT RNA (guanine-7-) methyltransferase
RTN1 reticulon 1
S100A2 S100 calcium binding protein A2
S100A7 S100 calcium binding protein A7
S100A8 S100 calcium binding protein A8
SDC1 syndecan 1
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFN stratifin
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SIK1 salt-inducible kinase 1
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SMAD7 SMAD family member 7
SOX11 SRY (sex determining region Y)-box 11
SPRY4 sprouty homolog 4 (Drosophila)
SQSTM1 sequestosome 1
STC2 stanniocalcin 2
STEAP1 six transmembrane epithelial antigen of the prostate 1
STK26 serine/threonine protein kinase 26
SULF1 sulfatase 1
SYNM synemin, intermediate filament protein
TGFA transforming growth factor, alpha
TKT transketolase
TMEM30B transmembrane protein 30B
TMEM45A transmembrane protein 45A
TMSB15A thymosin beta 15a
TNC tenascin C
TPBG trophoblast glycoprotein
TRIB1 tribbles pseudokinase 1
TRIB3 tribbles pseudokinase 3
TUBB6 tubulin, beta 6 class V
TUFT1 tuftelin 1
TXNRD1 thioredoxin reductase 1
UBE3C ubiquitin protein ligase E3C
UGDH UDP-glucose 6-dehydrogenase
UPP1 uridine phosphorylase 1
VEGFA vascular endothelial growth factor A
XBP1 X-box binding protein 1
ZNF292 zinc finger protein 292

decreased expression

Symbol Name
AGR2 anterior gradient 2
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ASCL1 achaete-scute family bHLH transcription factor 1
ASRGL1 asparaginase like 1
AURKA aurora kinase A
AURKB aurora kinase B
B3GNT1
BIRC5 baculoviral IAP repeat containing 5
CCNA2 cyclin A2
CCNF cyclin F
CD200 CD200 molecule
CDC20 cell division cycle 20
COPS7A COP9 signalosome subunit 7A
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
DAPK1 death-associated protein kinase 1
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
ECI2 enoyl-CoA delta isomerase 2
FGG fibrinogen gamma chain
FOLR1 folate receptor 1 (adult)
GPC3 glypican 3
GPM6A glycoprotein M6A
GRWD1 glutamate-rich WD repeat containing 1
HIST1H2BG histone cluster 1, H2bg
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGFBP4 insulin-like growth factor binding protein 4
KIF20A kinesin family member 20A
KIF2C kinesin family member 2C
LAMP5 lysosomal-associated membrane protein family, member 5
LOC100505650 uncharacterized LOC100505650
MEIS1 Meis homeobox 1
PDZK1 PDZ domain containing 1
PEBP1 phosphatidylethanolamine binding protein 1
PLK1 polo-like kinase 1
RBP1 retinol binding protein 1, cellular
RGS5 regulator of G-protein signaling 5
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SOX4 SRY (sex determining region Y)-box 4
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TPX2 TPX2, microtubule-associated
TUBB2A tubulin, beta 2A class IIa