BRD-K92317137_-666_NCIH1836_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

203 genes differentially expressed following the BRD-K92317137_-666_NCIH1836_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADM adrenomedullin
AEBP1 AE binding protein 1
AKAP8L A kinase (PRKA) anchor protein 8-like
ALDOC aldolase C, fructose-bisphosphate
APOD apolipoprotein D
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BAG3 BCL2-associated athanogene 3
BCL6 B-cell CLL/lymphoma 6
BIK BCL2-interacting killer (apoptosis-inducing)
BRD2 bromodomain containing 2
BUD31 BUD31 homolog (S. cerevisiae)
C6ORF48 chromosome 6 open reading frame 48
CCNL1 cyclin L1
CD163 CD163 molecule
CD24 CD24 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDC25A cell division cycle 25A
CDC6 cell division cycle 6
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN2AIP CDKN2A interacting protein
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CEMIP cell migration inducing protein, hyaluronan binding
CHMP1B charged multivesicular body protein 1B
CKS2 CDC28 protein kinase regulatory subunit 2
CLEC11A C-type lectin domain family 11, member A
CNN3 calponin 3, acidic
COL5A2 collagen, type V, alpha 2
COMP cartilage oligomeric matrix protein
CRISP3 cysteine-rich secretory protein 3
CSRP1 cysteine and glycine-rich protein 1
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DHRS2 dehydrogenase/reductase (SDR family) member 2
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP1 dual specificity phosphatase 1
DUSP2 dual specificity phosphatase 2
DUSP5 dual specificity phosphatase 5
EIF5 eukaryotic translation initiation factor 5
ELANE elastase, neutrophil expressed
EZR ezrin
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FTH1 ferritin, heavy polypeptide 1
GABPB1 GA binding protein transcription factor, beta subunit 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GCLM glutamate-cysteine ligase, modifier subunit
GLUL glutamate-ammonia ligase
GPRC5A G protein-coupled receptor, class C, group 5, member A
H1F0 H1 histone family, member 0
H2BFS H2B histone family, member S (pseudogene)
HBD hemoglobin, delta
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HEXIM1 hexamethylene bis-acetamide inducible 1
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2AE histone cluster 1, H2ae
HIST1H2BD histone cluster 1, H2bd
HIST1H2BF histone cluster 1, H2bf
HIST1H2BG histone cluster 1, H2bg
HIST1H2BK histone cluster 1, H2bk
HIST1H3H histone cluster 1, H3h
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA9 heat shock 70kDa protein 9 (mortalin)
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPH1 heat shock 105kDa/110kDa protein 1
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IDI1 isopentenyl-diphosphate delta isomerase 1
IER5 immediate early response 5
IFRD1 interferon-related developmental regulator 1
INPP5F inositol polyphosphate-5-phosphatase F
JMJD6 jumonji domain containing 6
JUNB jun B proto-oncogene
JUND jun D proto-oncogene
KLF4 Kruppel-like factor 4 (gut)
KRT19 keratin 19, type I
LCN2 lipocalin 2
LDLR low density lipoprotein receptor
LGALS8 lectin, galactoside-binding, soluble, 8
LRRC15 leucine rich repeat containing 15
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MCL1 myeloid cell leukemia 1
MGEA5 meningioma expressed antigen 5 (hyaluronidase)
MIR22HG MIR22 host gene
MS4A3 membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)
MSX1 msh homeobox 1
MXI1 MAX interactor 1, dimerization protein
NAMPT nicotinamide phosphoribosyltransferase
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NEU1 sialidase 1 (lysosomal sialidase)
NOLC1 nucleolar and coiled-body phosphoprotein 1
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
NXF1 nuclear RNA export factor 1
OSER1 oxidative stress responsive serine-rich 1
PELI1 pellino E3 ubiquitin protein ligase 1
PLK2 polo-like kinase 2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PNP purine nucleoside phosphorylase
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PPP1R2 protein phosphatase 1, regulatory (inhibitor) subunit 2
PTP4A1 protein tyrosine phosphatase type IVA, member 1
REL v-rel avian reticuloendotheliosis viral oncogene homolog
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGS2 regulator of G-protein signaling 2
RHOB ras homolog family member B
RIOK3 RIO kinase 3
RNMT RNA (guanine-7-) methyltransferase
S100A4 S100 calcium binding protein A4
S100A6 S100 calcium binding protein A6
S100P S100 calcium binding protein P
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SFRP4 secreted frizzled-related protein 4
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SNX6 sorting nexin 6
SPRED2 sprouty-related, EVH1 domain containing 2
SRGN serglycin
SRSF6 serine/arginine-rich splicing factor 6
SRSF7 serine/arginine-rich splicing factor 7
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa
TIMP3 TIMP metallopeptidase inhibitor 3
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TOB1 transducer of ERBB2, 1
TPBG trophoblast glycoprotein
TPD52 tumor protein D52
TRA2B transformer 2 beta homolog (Drosophila)
VCAM1 vascular cell adhesion molecule 1
VEGFA vascular endothelial growth factor A
WBP5 WW domain binding protein 5
WSB1 WD repeat and SOCS box containing 1
ZFAND5 zinc finger, AN1-type domain 5
ZFP36 ZFP36 ring finger protein
ZFP36L2 ZFP36 ring finger protein-like 2
ZNF394 zinc finger protein 394

decreased expression

Symbol Name
ACTG2 actin, gamma 2, smooth muscle, enteric
ADGRG6 adhesion G protein-coupled receptor G6
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADIPOQ adiponectin, C1Q and collagen domain containing
AHNAK2 AHNAK nucleoprotein 2
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
B3GNT1
CA12 carbonic anhydrase XII
CDK19 cyclin-dependent kinase 19
CELF2 CUGBP, Elav-like family member 2
CXCL14 chemokine (C-X-C motif) ligand 14
DIXDC1 DIX domain containing 1
DSC3 desmocollin 3
EI24 etoposide induced 2.4
FAM134B family with sequence similarity 134, member B
FHL1 four and a half LIM domains 1
FSD1 fibronectin type III and SPRY domain containing 1
GALNT11 polypeptide N-acetylgalactosaminyltransferase 11
GNPTAB N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits
IGSF3 immunoglobulin superfamily, member 3
LAMP3 lysosomal-associated membrane protein 3
LPL lipoprotein lipase
LRRN3 leucine rich repeat neuronal 3
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MAGED1 melanoma antigen family D1
MATN2 matrilin 2
MMP12 matrix metallopeptidase 12
NAV2 neuron navigator 2
NFIB nuclear factor I/B
NT5DC2 5'-nucleotidase domain containing 2
OSBPL8 oxysterol binding protein-like 8
PDE4B phosphodiesterase 4B, cAMP-specific
PDZK1IP1 PDZK1 interacting protein 1
PDZRN3 PDZ domain containing ring finger 3
PI3 peptidase inhibitor 3, skin-derived
PLK1 polo-like kinase 1
PROM1 prominin 1
PSD3 pleckstrin and Sec7 domain containing 3
PTGIS prostaglandin I2 (prostacyclin) synthase
SFRP1 secreted frizzled-related protein 1
SLAMF7 SLAM family member 7
SLC43A3 solute carrier family 43, member 3
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SOX4 SRY (sex determining region Y)-box 4
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TFPI2 tissue factor pathway inhibitor 2
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast)
TMF1 TATA element modulatory factor 1
TNS3 tensin 3
TUSC3 tumor suppressor candidate 3
TYRP1 tyrosinase-related protein 1
VIM vimentin
VNN1 vanin 1