BRD-K92317137_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

274 genes differentially expressed following the BRD-K92317137_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACSL3 acyl-CoA synthetase long-chain family member 3
ADM adrenomedullin
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ANKRD12 ankyrin repeat domain 12
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
ARC activity-regulated cytoskeleton-associated protein
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATG101 autophagy related 101
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
AUTS2 autism susceptibility candidate 2
AZU1 azurocidin 1
BHLHE40 basic helix-loop-helix family, member e40
BIK BCL2-interacting killer (apoptosis-inducing)
BTG1 B-cell translocation gene 1, anti-proliferative
CANX calnexin
CAPN2 calpain 2, (m/II) large subunit
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CEMIP cell migration inducing protein, hyaluronan binding
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CLGN calmegin
CLU clusterin
COL6A1 collagen, type VI, alpha 1
COL6A2 collagen, type VI, alpha 2
COL9A3 collagen, type IX, alpha 3
COTL1 coactosin-like F-actin binding protein 1
CSRP2 cysteine and glycine-rich protein 2
CTGF connective tissue growth factor
CTH cystathionine gamma-lyase
CXCL8 chemokine (C-X-C motif) ligand 8
CXCR4 chemokine (C-X-C motif) receptor 4
CYR61 cysteine-rich, angiogenic inducer, 61
DACH1 dachshund family transcription factor 1
DDAH1 dimethylarginine dimethylaminohydrolase 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DLX2 distal-less homeobox 2
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DUSP1 dual specificity phosphatase 1
DUSP2 dual specificity phosphatase 2
DUSP5 dual specificity phosphatase 5
EGR1 early growth response 1
EGR3 early growth response 3
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3
EIF5 eukaryotic translation initiation factor 5
ELANE elastase, neutrophil expressed
EPHA2 EPH receptor A2
EPRS glutamyl-prolyl-tRNA synthetase
EPS8 epidermal growth factor receptor pathway substrate 8
EZR ezrin
FAM46A family with sequence similarity 46, member A
FCGRT Fc fragment of IgG, receptor, transporter, alpha
FN1 fibronectin 1
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
FOSL2 FOS-like antigen 2
FOXD1 forkhead box D1
FOXF1 forkhead box F1
GADD45B growth arrest and DNA-damage-inducible, beta
GEM GTP binding protein overexpressed in skeletal muscle
HBEGF heparin-binding EGF-like growth factor
HCAR3 hydroxycarboxylic acid receptor 3
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HPCAL1 hippocalcin-like 1
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA1A heat shock 70kDa protein 1A
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPH1 heat shock 105kDa/110kDa protein 1
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IER2 immediate early response 2
IFRD1 interferon-related developmental regulator 1
IGHD immunoglobulin heavy constant delta
IL6ST interleukin 6 signal transducer
INSIG1 insulin induced gene 1
IRS2 insulin receptor substrate 2
JMJD6 jumonji domain containing 6
JUN jun proto-oncogene
JUNB jun B proto-oncogene
JUND jun D proto-oncogene
KDM5D lysine (K)-specific demethylase 5D
KDM6B lysine (K)-specific demethylase 6B
KLF2 Kruppel-like factor 2
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
KLF9 Kruppel-like factor 9
LDLR low density lipoprotein receptor
LEF1 lymphoid enhancer-binding factor 1
LIF leukemia inhibitory factor
LPAR1 lysophosphatidic acid receptor 1
LYST lysosomal trafficking regulator
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MARCH6 membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligase
MCL1 myeloid cell leukemia 1
MIR22HG MIR22 host gene
MSLN mesothelin
MSX1 msh homeobox 1
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1HL1 metallothionein 1H-like 1
MT1M metallothionein 1M
MT1X metallothionein 1X
MVP major vault protein
NAV3 neuron navigator 3
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NFE2L2 nuclear factor, erythroid 2-like 2
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
ODC1 ornithine decarboxylase 1
OSMR oncostatin M receptor
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1
PDP1 pyruvate dehyrogenase phosphatase catalytic subunit 1
PELI1 pellino E3 ubiquitin protein ligase 1
PER1 period circadian clock 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PKD1P1 polycystic kidney disease 1 (autosomal dominant) pseudogene 1
PLAUR plasminogen activator, urokinase receptor
PLK2 polo-like kinase 2
PNKP polynucleotide kinase 3'-phosphatase
PPARG peroxisome proliferator-activated receptor gamma
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRTN3 proteinase 3
PTX3 pentraxin 3, long
RBP4 retinol binding protein 4, plasma
RCAN1 regulator of calcineurin 1
RGS2 regulator of G-protein signaling 2
RHOB ras homolog family member B
RND3 Rho family GTPase 3
RPS4Y1 ribosomal protein S4, Y-linked 1
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
SAT1 spermidine/spermine N1-acetyltransferase 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SERTAD2 SERTA domain containing 2
SIK1 salt-inducible kinase 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLIT2 slit homolog 2 (Drosophila)
SOCS2 suppressor of cytokine signaling 2
SOX9 SRY (sex determining region Y)-box 9
SPRED2 sprouty-related, EVH1 domain containing 2
SPRY4 sprouty homolog 4 (Drosophila)
SQSTM1 sequestosome 1
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
STX1A syntaxin 1A (brain)
TARS threonyl-tRNA synthetase
TBX3 T-box 3
TGFA transforming growth factor, alpha
TGFBI transforming growth factor, beta-induced, 68kDa
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TIMP3 TIMP metallopeptidase inhibitor 3
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TRIB1 tribbles pseudokinase 1
TRIB3 tribbles pseudokinase 3
TRIO trio Rho guanine nucleotide exchange factor
TUBB2B tubulin, beta 2B class IIb
TXNRD1 thioredoxin reductase 1
UGCG UDP-glucose ceramide glucosyltransferase
VEGFA vascular endothelial growth factor A
WARS tryptophanyl-tRNA synthetase
ZBTB20 zinc finger and BTB domain containing 20
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ABLIM1 actin binding LIM protein 1
ACTA2 actin, alpha 2, smooth muscle, aorta
AHNAK2 AHNAK nucleoprotein 2
APP amyloid beta (A4) precursor protein
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
B3GNT1
BDH1 3-hydroxybutyrate dehydrogenase, type 1
BHLHE41 basic helix-loop-helix family, member e41
BNC2 basonuclin 2
C14ORF169 chromosome 14 open reading frame 169
CA12 carbonic anhydrase XII
CD58 CD58 molecule
CELSR2 cadherin, EGF LAG seven-pass G-type receptor 2
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
CLCA4 chloride channel accessory 4
COX11 COX11 cytochrome c oxidase copper chaperone
CPE carboxypeptidase E
CTSC cathepsin C
CYP26B1 cytochrome P450, family 26, subfamily B, polypeptide 1
DMD dystrophin
DUOX2 dual oxidase 2
ENO1 enolase 1, (alpha)
ESR1 estrogen receptor 1
FCGBP Fc fragment of IgG binding protein
GATA3 GATA binding protein 3
GBAS glioblastoma amplified sequence
GEMIN2 gem (nuclear organelle) associated protein 2
GINS1 GINS complex subunit 1 (Psf1 homolog)
GJA1 gap junction protein, alpha 1, 43kDa
GREM1 gremlin 1, DAN family BMP antagonist
GRWD1 glutamate-rich WD repeat containing 1
GSPT2 G1 to S phase transition 2
H2AFX H2A histone family, member X
HIST1H1C histone cluster 1, H1c
HIST1H4C histone cluster 1, H4c
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMGN3 high mobility group nucleosomal binding domain 3
HN1 hematological and neurological expressed 1
HOPX HOP homeobox
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IGSF3 immunoglobulin superfamily, member 3
IMP3 IMP3, U3 small nucleolar ribonucleoprotein
KRT15 keratin 15, type I
KRT6B keratin 6B, type II
MGAT2 mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
MGP matrix Gla protein
MMP9 matrix metallopeptidase 9
MREG melanoregulin
MRPL15 mitochondrial ribosomal protein L15
MYH10 myosin, heavy chain 10, non-muscle
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NFIB nuclear factor I/B
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NME4 NME/NM23 nucleoside diphosphate kinase 4
NPY1R neuropeptide Y receptor Y1
NSL1 NSL1, MIS12 kinetochore complex component
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
NUP62 nucleoporin 62kDa
PDLIM3 PDZ and LIM domain 3
PFN2 profilin 2
PLK1 polo-like kinase 1
PLN phospholamban
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
POLR1C polymerase (RNA) I polypeptide C, 30kDa
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RPP38 ribonuclease P/MRP 38kDa subunit
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
S100A9 S100 calcium binding protein A9
SEMA6A sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SESN1 sestrin 1
SH3BGRL SH3 domain binding glutamate-rich protein like
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SOX4 SRY (sex determining region Y)-box 4
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SULF1 sulfatase 1
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
SYNGR2 synaptogyrin 2
TGFBR3 transforming growth factor, beta receptor III
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TRIM29 tripartite motif containing 29
TYROBP TYRO protein tyrosine kinase binding protein
ZFP36L2 ZFP36 ring finger protein-like 2
ZNF185 zinc finger protein 185 (LIM domain)
ZNF589 zinc finger protein 589