BRD-K92317137_-666_HT29_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

380 genes differentially expressed following the BRD-K92317137_-666_HT29_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ABHD3 abhydrolase domain containing 3
ACSL3 acyl-CoA synthetase long-chain family member 3
ADIRF adipogenesis regulatory factor
ADM adrenomedullin
AGR2 anterior gradient 2
AHNAK AHNAK nucleoprotein
AKAP12 A kinase (PRKA) anchor protein 12
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ANKRD10 ankyrin repeat domain 10
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
AQP1 aquaporin 1 (Colton blood group)
ARC activity-regulated cytoskeleton-associated protein
ARID4B AT rich interactive domain 4B (RBP1-like)
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
AXL AXL receptor tyrosine kinase
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BAG3 BCL2-associated athanogene 3
BCL3 B-cell CLL/lymphoma 3
BHLHE40 basic helix-loop-helix family, member e40
BLNK B-cell linker
BLVRB biliverdin reductase B
BRD2 bromodomain containing 2
BTG1 B-cell translocation gene 1, anti-proliferative
BTG2 BTG family, member 2
C1QA complement component 1, q subcomponent, A chain
C1QB complement component 1, q subcomponent, B chain
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CAPRIN2 caprin family member 2
CAV1 caveolin 1, caveolae protein, 22kDa
CCNL1 cyclin L1
CD163 CD163 molecule
CD69 CD69 molecule
CD83 CD83 molecule
CD9 CD9 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CLDN4 claudin 4
COL6A2 collagen, type VI, alpha 2
COL9A3 collagen, type IX, alpha 3
COTL1 coactosin-like F-actin binding protein 1
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CRYAB crystallin, alpha B
CSRP2 cysteine and glycine-rich protein 2
CTSH cathepsin H
CTSL cathepsin L
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
CYR61 cysteine-rich, angiogenic inducer, 61
CYTH1 cytohesin 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DHRS2 dehydrogenase/reductase (SDR family) member 2
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
DSP desmoplakin
DST dystonin
DUSP1 dual specificity phosphatase 1
DUSP2 dual specificity phosphatase 2
DUSP5 dual specificity phosphatase 5
EFHD1 EF-hand domain family, member D1
EFNB2 ephrin-B2
EGR1 early growth response 1
EGR2 early growth response 2
EGR3 early growth response 3
EIF5 eukaryotic translation initiation factor 5
EMP1 epithelial membrane protein 1
EPCAM epithelial cell adhesion molecule
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
EZR ezrin
F3 coagulation factor III (thromboplastin, tissue factor)
FBN2 fibrillin 2
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
FCMR Fc fragment of IgM receptor
FHL2 four and a half LIM domains 2
FOLR1 folate receptor 1 (adult)
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
FOSL2 FOS-like antigen 2
FXYD3 FXYD domain containing ion transport regulator 3
FZD10 frizzled class receptor 10
FZD7 frizzled class receptor 7
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GAS6 growth arrest-specific 6
GATA2 GATA binding protein 2
GEM GTP binding protein overexpressed in skeletal muscle
GPRC5A G protein-coupled receptor, class C, group 5, member A
HBB hemoglobin, beta
HBEGF heparin-binding EGF-like growth factor
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H2BK histone cluster 1, H2bk
HIST1H4H histone cluster 1, H4h
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HN1 hematological and neurological expressed 1
HPCAL1 hippocalcin-like 1
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSPA1A heat shock 70kDa protein 1A
HSPA2 heat shock 70kDa protein 2
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
HSPB1 heat shock 27kDa protein 1
HSPB8 heat shock 22kDa protein 8
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPE1 heat shock 10kDa protein 1
HSPH1 heat shock 105kDa/110kDa protein 1
HYOU1 hypoxia up-regulated 1
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IER2 immediate early response 2
IER3 immediate early response 3
IER5 immediate early response 5
IFI27 interferon, alpha-inducible protein 27
IFRD1 interferon-related developmental regulator 1
IGF1R insulin-like growth factor 1 receptor
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2
IGFBP5 insulin-like growth factor binding protein 5
IGFBP7 insulin-like growth factor binding protein 7
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
IGL immunoglobulin lambda locus
IL6ST interleukin 6 signal transducer
INPP5A inositol polyphosphate-5-phosphatase, 40kDa
INSIG1 insulin induced gene 1
IRF1 interferon regulatory factor 1
IRF7 interferon regulatory factor 7
ISG20 interferon stimulated exonuclease gene 20kDa
ITGA6 integrin, alpha 6
JMJD6 jumonji domain containing 6
JUN jun proto-oncogene
JUNB jun B proto-oncogene
JUND jun D proto-oncogene
KDM3A lysine (K)-specific demethylase 3A
KDM6B lysine (K)-specific demethylase 6B
KLF10 Kruppel-like factor 10
KLF11 Kruppel-like factor 11
KLF2 Kruppel-like factor 2
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
KLF9 Kruppel-like factor 9
KRT14 keratin 14, type I
KRT17 keratin 17, type I
KRT19 keratin 19, type I
KRT5 keratin 5, type II
KRT6A keratin 6A, type II
LAMA3 laminin, alpha 3
LDLR low density lipoprotein receptor
LEF1 lymphoid enhancer-binding factor 1
LGALS3 lectin, galactoside-binding, soluble, 3
LINC00341 long intergenic non-protein coding RNA 341
LMNA lamin A/C
LMO4 LIM domain only 4
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MCL1 myeloid cell leukemia 1
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MGLL monoglyceride lipase
MICB MHC class I polypeptide-related sequence B
MINK1 misshapen-like kinase 1
MIR22HG MIR22 host gene
MKNK2 MAP kinase interacting serine/threonine kinase 2
MMP11 matrix metallopeptidase 11
MSMB microseminoprotein, beta-
MSX1 msh homeobox 1
MT1M metallothionein 1M
MT1X metallothionein 1X
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MTSS1 metastasis suppressor 1
MUC5B mucin 5B, oligomeric mucus/gel-forming
NAMPT nicotinamide phosphoribosyltransferase
NDRG1 N-myc downstream regulated 1
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NEU1 sialidase 1 (lysosomal sialidase)
NOTCH1 notch 1
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
OAT ornithine aminotransferase
ODC1 ornithine decarboxylase 1
OLFML2A olfactomedin-like 2A
OSR2 odd-skipped related transciption factor 2
OXSR1 oxidative stress responsive 1
PDGFA platelet-derived growth factor alpha polypeptide
PELI1 pellino E3 ubiquitin protein ligase 1
PER1 period circadian clock 1
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PIM1 Pim-1 proto-oncogene, serine/threonine kinase
PLAGL1 pleiomorphic adenoma gene-like 1
PLAT plasminogen activator, tissue
PLAUR plasminogen activator, urokinase receptor
PLD3 phospholipase D family, member 3
PLEC plectin
PLK2 polo-like kinase 2
PLTP phospholipid transfer protein
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PMP22 peripheral myelin protein 22
POR P450 (cytochrome) oxidoreductase
PPARD peroxisome proliferator-activated receptor delta
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRKCZ protein kinase C, zeta
PTP4A1 protein tyrosine phosphatase type IVA, member 1
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
RALGDS ral guanine nucleotide dissociation stimulator
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGS1 regulator of G-protein signaling 1
RGS16 regulator of G-protein signaling 16
RGS2 regulator of G-protein signaling 2
RHOB ras homolog family member B
RIOK3 RIO kinase 3
RND1 Rho family GTPase 1
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
RRBP1 ribosome binding protein 1
S100A10 S100 calcium binding protein A10
S100A14 S100 calcium binding protein A14
S100B S100 calcium binding protein B
S100P S100 calcium binding protein P
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCG5 secretogranin V
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SFN stratifin
SIK1 salt-inducible kinase 1
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMAD3 SMAD family member 3
SOCS3 suppressor of cytokine signaling 3
SOX9 SRY (sex determining region Y)-box 9
SPAG9 sperm associated antigen 9
SPTAN1 spectrin, alpha, non-erythrocytic 1
SPTBN1 spectrin, beta, non-erythrocytic 1
SQSTM1 sequestosome 1
STC2 stanniocalcin 2
STK10 serine/threonine kinase 10
STK17A serine/threonine kinase 17a
TGFA transforming growth factor, alpha
TGFBI transforming growth factor, beta-induced, 68kDa
THBD thrombomodulin
TICAM1 toll-like receptor adaptor molecule 1
TIMP2 TIMP metallopeptidase inhibitor 2
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TJP1 tight junction protein 1
TMEM2 transmembrane protein 2
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
TRIB1 tribbles pseudokinase 1
TRIB3 tribbles pseudokinase 3
TSC22D3 TSC22 domain family, member 3
TSPAN13 tetraspanin 13
TSPYL2 TSPY-like 2
TUBB2A tubulin, beta 2A class IIa
TUBB2B tubulin, beta 2B class IIb
TUFT1 tuftelin 1
TWIST1 twist family bHLH transcription factor 1
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
UBE2B ubiquitin-conjugating enzyme E2B
UBE2H ubiquitin-conjugating enzyme E2H
UGCG UDP-glucose ceramide glucosyltransferase
UGDH UDP-glucose 6-dehydrogenase
UPP1 uridine phosphorylase 1
VEGFA vascular endothelial growth factor A
XBP1 X-box binding protein 1
ZFP36 ZFP36 ring finger protein
ZFP36L1 ZFP36 ring finger protein-like 1
ZNF165 zinc finger protein 165

decreased expression

Symbol Name
ABCF3 ATP-binding cassette, sub-family F (GCN20), member 3
ABHD10 abhydrolase domain containing 10
ACTA2 actin, alpha 2, smooth muscle, aorta
AKR1C3 aldo-keto reductase family 1, member C3
ALDH1B1 aldehyde dehydrogenase 1 family, member B1
ALOX5AP arachidonate 5-lipoxygenase-activating protein
ANKRD46 ankyrin repeat domain 46
ANOS1 anosmin 1
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ARID5B AT rich interactive domain 5B (MRF1-like)
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
B3GNT1
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
BMP4 bone morphogenetic protein 4
BST2 bone marrow stromal cell antigen 2
C14ORF169 chromosome 14 open reading frame 169
CCNA2 cyclin A2
CCNF cyclin F
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CPD carboxypeptidase D
CSTF1 cleavage stimulation factor, 3' pre-RNA, subunit 1, 50kDa
DCUN1D1 DCN1, defective in cullin neddylation 1, domain containing 1
DUSP6 dual specificity phosphatase 6
EIF1AX eukaryotic translation initiation factor 1A, X-linked
EXOSC4 exosome component 4
FAM129A family with sequence similarity 129, member A
FGFR2 fibroblast growth factor receptor 2
FLRT2 fibronectin leucine rich transmembrane protein 2
GIMAP4 GTPase, IMAP family member 4
GLIPR1 GLI pathogenesis-related 1
GPR171 G protein-coupled receptor 171
GREM1 gremlin 1, DAN family BMP antagonist
GSPT2 G1 to S phase transition 2
GTF3A general transcription factor IIIA
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HOPX HOP homeobox
IDO1 indoleamine 2,3-dioxygenase 1
IL13RA2 interleukin 13 receptor, alpha 2
IMP3 IMP3, U3 small nucleolar ribonucleoprotein
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
JADE1 jade family PHD finger 1
KCNS3 potassium voltage-gated channel, modifier subfamily S, member 3
LAPTM4B lysosomal protein transmembrane 4 beta
LMO3 LIM domain only 3 (rhombotin-like 2)
LXN latexin
LY6E lymphocyte antigen 6 complex, locus E
MAN1A2 mannosidase, alpha, class 1A, member 2
MKL2 MKL/myocardin-like 2
MMP9 matrix metallopeptidase 9
MRPL17 mitochondrial ribosomal protein L17
MYC v-myc avian myelocytomatosis viral oncogene homolog
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NFIB nuclear factor I/B
NREP neuronal regeneration related protein
NRIP1 nuclear receptor interacting protein 1
PCDH7 protocadherin 7
PDE4B phosphodiesterase 4B, cAMP-specific
PDZK1IP1 PDZK1 interacting protein 1
PLK1 polo-like kinase 1
PLN phospholamban
POGLUT1 protein O-glucosyltransferase 1
POLR1C polymerase (RNA) I polypeptide C, 30kDa
POLR3K polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa
PRPF4 pre-mRNA processing factor 4
PTGIS prostaglandin I2 (prostacyclin) synthase
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RPP38 ribonuclease P/MRP 38kDa subunit
RRP8 ribosomal RNA processing 8, methyltransferase, homolog (yeast)
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SEPHS1 selenophosphate synthetase 1
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC25A15 solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SRGN serglycin
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TFPI2 tissue factor pathway inhibitor 2
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TMEM177 transmembrane protein 177
TMF1 TATA element modulatory factor 1
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TRIAP1 TP53 regulated inhibitor of apoptosis 1
TRIM27 tripartite motif containing 27
TYRP1 tyrosinase-related protein 1
UMPS uridine monophosphate synthetase
WNT5A wingless-type MMTV integration site family, member 5A
ZBED5 zinc finger, BED-type containing 5
ZNF22 zinc finger protein 22
ZNF586 zinc finger protein 586