BRD-K92301463_-666_HCC515_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

59 genes differentially expressed following the BRD-K92301463_-666_HCC515_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ATF3 activating transcription factor 3
BHLHE40 basic helix-loop-helix family, member e40
CTSL cathepsin L
CXCL8 chemokine (C-X-C motif) ligand 8
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
EGR1 early growth response 1
EGR3 early growth response 3
FASTKD5 FAST kinase domains 5
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
G6PD glucose-6-phosphate dehydrogenase
GCLC glutamate-cysteine ligase, catalytic subunit
GEM GTP binding protein overexpressed in skeletal muscle
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IL1RN interleukin 1 receptor antagonist
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KLF4 Kruppel-like factor 4 (gut)
KYNU kynureninase
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
NRIP1 nuclear receptor interacting protein 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLIN2 perilipin 2
PPP1R15A protein phosphatase 1, regulatory subunit 15A
RGS2 regulator of G-protein signaling 2
SATB1 SATB homeobox 1
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SERTAD2 SERTA domain containing 2
SNX10 sorting nexin 10
SOX9 SRY (sex determining region Y)-box 9
STX1A syntaxin 1A (brain)
TCTA T-cell leukemia translocation altered
TKT transketolase
TUBB2A tubulin, beta 2A class IIa
TXNRD1 thioredoxin reductase 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)

decreased expression

Symbol Name
ASS1 argininosuccinate synthase 1
CALB1 calbindin 1, 28kDa
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CPA3 carboxypeptidase A3 (mast cell)
CYBA cytochrome b-245, alpha polypeptide
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
GSTM3 glutathione S-transferase mu 3 (brain)
HOXA5 homeobox A5
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
INPP5A inositol polyphosphate-5-phosphatase, 40kDa
NEBL nebulette
NUAK1 NUAK family, SNF1-like kinase, 1
PEG10 paternally expressed 10
SCUBE2 signal peptide, CUB domain, EGF-like 2
VTCN1 V-set domain containing T cell activation inhibitor 1