BRD-K92158425_N-((5-chloro-1H-benzo[d]imidazol-2-yl)methyl)-2-morpholino-9-(thiophen-3-yl)-9H-purin-6-amine_HT29_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

240 genes differentially expressed following the BRD-K92158425_N-((5-chloro-1H-benzo[d]imidazol-2-yl)methyl)-2-morpholino-9-(thiophen-3-yl)-9H-purin-6-amine_HT29_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
ACTR2 ARP2 actin-related protein 2 homolog (yeast)
ADD3 adducin 3 (gamma)
AIDA axin interactor, dorsalization associated
ATF3 activating transcription factor 3
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
BEX4 brain expressed, X-linked 4
BSG basigin (Ok blood group)
BTG2 BTG family, member 2
C21ORF33 chromosome 21 open reading frame 33
CD177 CD177 molecule
CD24 CD24 molecule
CLIC4 chloride intracellular channel 4
CLIC5 chloride intracellular channel 5
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
COMMD8 COMM domain containing 8
CTSB cathepsin B
CYR61 cysteine-rich, angiogenic inducer, 61
DCN decorin
DKK3 dickkopf WNT signaling pathway inhibitor 3
DNAJC10 DnaJ (Hsp40) homolog, subfamily C, member 10
DPYSL3 dihydropyrimidinase-like 3
EGR1 early growth response 1
FKBP1A FK506 binding protein 1A, 12kDa
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
GADD45B growth arrest and DNA-damage-inducible, beta
GULP1 GULP, engulfment adaptor PTB domain containing 1
HES1 hes family bHLH transcription factor 1
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IER3 immediate early response 3
IFITM3 interferon induced transmembrane protein 3
IGFBP5 insulin-like growth factor binding protein 5
IGFBP7 insulin-like growth factor binding protein 7
L1CAM L1 cell adhesion molecule
LAPTM4B lysosomal protein transmembrane 4 beta
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LTA4H leukotriene A4 hydrolase
LUM lumican
MFAP2 microfibrillar-associated protein 2
MME membrane metallo-endopeptidase
MMP9 matrix metallopeptidase 9
NR4A1 nuclear receptor subfamily 4, group A, member 1
NREP neuronal regeneration related protein
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PDLIM1 PDZ and LIM domain 1
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PROSC proline synthetase co-transcribed homolog (bacterial)
PSPH phosphoserine phosphatase
RBP1 retinol binding protein 1, cellular
RGS5 regulator of G-protein signaling 5
RPRD1A regulation of nuclear pre-mRNA domain containing 1A
RPS4Y1 ribosomal protein S4, Y-linked 1
RPS5 ribosomal protein S5
SCARB2 scavenger receptor class B, member 2
SEPT2 septin 2
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SKP1 S-phase kinase-associated protein 1
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SRP9 signal recognition particle 9kDa
THBS1 thrombospondin 1
THBS2 thrombospondin 2
TMSB15A thymosin beta 15a
TNNC1 troponin C type 1 (slow)
TNNT1 troponin T type 1 (skeletal, slow)
TUBA1A tubulin, alpha 1a
TUSC3 tumor suppressor candidate 3
VIM vimentin
VTCN1 V-set domain containing T cell activation inhibitor 1
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
ZSCAN18 zinc finger and SCAN domain containing 18

decreased expression

Symbol Name
ABCF3 ATP-binding cassette, sub-family F (GCN20), member 3
ACBD3 acyl-CoA binding domain containing 3
ACTN1 actinin, alpha 1
ADGRG2 adhesion G protein-coupled receptor G2
ADNP activity-dependent neuroprotector homeobox
ADO 2-aminoethanethiol (cysteamine) dioxygenase
AIM1 absent in melanoma 1
AKR1C3 aldo-keto reductase family 1, member C3
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
AURKA aurora kinase A
AXIN1 axin 1
BAG3 BCL2-associated athanogene 3
BAG5 BCL2-associated athanogene 5
BLCAP bladder cancer associated protein
BMP4 bone morphogenetic protein 4
C14ORF169 chromosome 14 open reading frame 169
CANT1 calcium activated nucleotidase 1
CAPN6 calpain 6
CCNA2 cyclin A2
CCNB1 cyclin B1
CCNF cyclin F
CDC25A cell division cycle 25A
CDC25B cell division cycle 25B
CDC42EP4 CDC42 effector protein (Rho GTPase binding) 4
CDC6 cell division cycle 6
CDK7 cyclin-dependent kinase 7
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta
CENPA centromere protein A
CHERP calcium homeostasis endoplasmic reticulum protein
COIL coilin
CSNK1D casein kinase 1, delta
DBF4 DBF4 zinc finger
DDX28 DEAD (Asp-Glu-Ala-Asp) box polypeptide 28
DDX39A DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2
DUSP14 dual specificity phosphatase 14
EPS8 epidermal growth factor receptor pathway substrate 8
ETV5 ets variant 5
F5 coagulation factor V (proaccelerin, labile factor)
FAM208B family with sequence similarity 208, member B
FAM46A family with sequence similarity 46, member A
FGF13 fibroblast growth factor 13
FOSL1 FOS-like antigen 1
FOXJ3 forkhead box J3
FRAT2 frequently rearranged in advanced T-cell lymphomas 2
GABPB1 GA binding protein transcription factor, beta subunit 1
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GDF15 growth differentiation factor 15
GEMIN4 gem (nuclear organelle) associated protein 4
GNE glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
GOSR1 golgi SNAP receptor complex member 1
GRWD1 glutamate-rich WD repeat containing 1
GSPT2 G1 to S phase transition 2
H2AFX H2A histone family, member X
HMOX1 heme oxygenase 1
HSPA14 heat shock 70kDa protein 14
HSPH1 heat shock 105kDa/110kDa protein 1
IMP3 IMP3, U3 small nucleolar ribonucleoprotein
INPP1 inositol polyphosphate-1-phosphatase
ISG20L2 interferon stimulated exonuclease gene 20kDa-like 2
JADE2 jade family PHD finger 2
JMJD6 jumonji domain containing 6
KANK1 KN motif and ankyrin repeat domains 1
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KEAP1 kelch-like ECH-associated protein 1
KIF20A kinesin family member 20A
KLHL21 kelch-like family member 21
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
LYZ lysozyme
MAP1S microtubule-associated protein 1S
MAPK6 mitogen-activated protein kinase 6
MARCH3 membrane-associated ring finger (C3HC4) 3, E3 ubiquitin protein ligase
METTL18 methyltransferase like 18
MFSD5 major facilitator superfamily domain containing 5
MLPH melanophilin
MTF2 metal response element binding transcription factor 2
MYC v-myc avian myelocytomatosis viral oncogene homolog
NDC80 NDC80 kinetochore complex component
NET1 neuroepithelial cell transforming 1
NGDN neuroguidin, EIF4E binding protein
NOL11 nucleolar protein 11
NOP16 NOP16 nucleolar protein
NOP56 NOP56 ribonucleoprotein
NR2F6 nuclear receptor subfamily 2, group F, member 6
NRIP1 nuclear receptor interacting protein 1
NUFIP1 nuclear fragile X mental retardation protein interacting protein 1
NUP62 nucleoporin 62kDa
NXT1 nuclear transport factor 2-like export factor 1
PATZ1 POZ (BTB) and AT hook containing zinc finger 1
PDS5B PDS5 cohesin associated factor B
PELO pelota homolog (Drosophila)
PFKP phosphofructokinase, platelet
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLK1 polo-like kinase 1
PPARG peroxisome proliferator-activated receptor gamma
PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2)
PROM1 prominin 1
RAE1 ribonucleic acid export 1
RBM15 RNA binding motif protein 15
RGS2 regulator of G-protein signaling 2
RNF139 ring finger protein 139
RNF219 ring finger protein 219
RNF4 ring finger protein 4
RNMT RNA (guanine-7-) methyltransferase
RPP38 ribonuclease P/MRP 38kDa subunit
RREB1 ras responsive element binding protein 1
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
RYBP RING1 and YY1 binding protein
S100P S100 calcium binding protein P
SACS sacsin molecular chaperone
SASH1 SAM and SH3 domain containing 1
SCAF8 SR-related CTD-associated factor 8
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SLC38A2 solute carrier family 38, member 2
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SOX9 SRY (sex determining region Y)-box 9
SPRY2 sprouty homolog 2 (Drosophila)
SRGN serglycin
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACC2 transforming, acidic coiled-coil containing protein 2
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa
TAF9 TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa
TBP TATA box binding protein
TBPL1 TBP-like 1
TCERG1 transcription elongation regulator 1
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TEX10 testis expressed 10
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TFF1 trefoil factor 1
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TM4SF4 transmembrane 4 L six family member 4
TMEM11 transmembrane protein 11
TMEM2 transmembrane protein 2
TNPO1 transportin 1
TOMM70A translocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae)
TSC22D2 TSC22 domain family, member 2
TSKU tsukushi, small leucine rich proteoglycan
TXLNA taxilin alpha
UBAP2L ubiquitin associated protein 2-like
UBE2S ubiquitin-conjugating enzyme E2S
UMPS uridine monophosphate synthetase
USP22 ubiquitin specific peptidase 22
UTP3 UTP3, small subunit (SSU) processome component, homolog (S. cerevisiae)
VPS37B vacuolar protein sorting 37 homolog B (S. cerevisiae)
WAPAL wings apart-like homolog (Drosophila)
WEE1 WEE1 G2 checkpoint kinase
WIPF2 WAS/WASL interacting protein family, member 2
XBP1 X-box binding protein 1
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1
ZBTB18 zinc finger and BTB domain containing 18
ZCCHC2 zinc finger, CCHC domain containing 2
ZNF574 zinc finger protein 574
ZYX zyxin