BRD-K92107474_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

85 genes differentially expressed following the BRD-K92107474_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
ALOX5 arachidonate 5-lipoxygenase
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
AUTS2 autism susceptibility candidate 2
AZGP1 alpha-2-glycoprotein 1, zinc-binding
B4GALT1 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1
BIRC3 baculoviral IAP repeat containing 3
CCL20 chemokine (C-C motif) ligand 20
COL11A1 collagen, type XI, alpha 1
COL1A1 collagen, type I, alpha 1
DCN decorin
EGR3 early growth response 3
FN1 fibronectin 1
FOXO1 forkhead box O1
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
HMOX1 heme oxygenase 1
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
LEF1 lymphoid enhancer-binding factor 1
MMP9 matrix metallopeptidase 9
NID2 nidogen 2 (osteonidogen)
NKX3-1 NK3 homeobox 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NT5E 5'-nucleotidase, ecto (CD73)
RBP4 retinol binding protein 4, plasma
RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis)
SCGB1D2 secretoglobin, family 1D, member 2
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SMARCA1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1
SORD sorbitol dehydrogenase
STEAP1 six transmembrane epithelial antigen of the prostate 1
TFPI2 tissue factor pathway inhibitor 2
THY1 Thy-1 cell surface antigen
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TSPAN5 tetraspanin 5
ZNF331 zinc finger protein 331

decreased expression

Symbol Name
ACTB actin, beta
ADAMDEC1 ADAM-like, decysin 1
AHR aryl hydrocarbon receptor
BASP1 brain abundant, membrane attached signal protein 1
BEX1 brain expressed, X-linked 1
CD58 CD58 molecule
CES2 carboxylesterase 2
CHEK1 checkpoint kinase 1
CLTB clathrin, light chain B
CSTA cystatin A (stefin A)
DSC2 desmocollin 2
EIF5 eukaryotic translation initiation factor 5
EPAS1 endothelial PAS domain protein 1
EXT1 exostosin glycosyltransferase 1
FABP5 fatty acid binding protein 5 (psoriasis-associated)
HEPH hephaestin
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HN1 hematological and neurological expressed 1
KIF14 kinesin family member 14
KRAS Kirsten rat sarcoma viral oncogene homolog
KRT6B keratin 6B, type II
LYZ lysozyme
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAPK6 mitogen-activated protein kinase 6
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain)
NXT2 nuclear transport factor 2-like export factor 2
OLFM4 olfactomedin 4
PALLD palladin, cytoskeletal associated protein
PLAC8 placenta-specific 8
PPIC peptidylprolyl isomerase C (cyclophilin C)
PTEN phosphatase and tensin homolog
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PXMP2 peroxisomal membrane protein 2, 22kDa
RALGDS ral guanine nucleotide dissociation stimulator
REG1A regenerating islet-derived 1 alpha
REG3A regenerating islet-derived 3 alpha
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SRC SRC proto-oncogene, non-receptor tyrosine kinase
STK38L serine/threonine kinase 38 like
SUB1 SUB1 homolog (S. cerevisiae)
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae)
TACC2 transforming, acidic coiled-coil containing protein 2
TM4SF1 transmembrane 4 L six family member 1
TMEM5 transmembrane protein 5