BRD-K92049597_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

81 genes differentially expressed following the BRD-K92049597_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
ACTA1 actin, alpha 1, skeletal muscle
CCDC86 coiled-coil domain containing 86
CD9 CD9 molecule
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CLC Charcot-Leyden crystal galectin
DCN decorin
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
FAM69A family with sequence similarity 69, member A
GULP1 GULP, engulfment adaptor PTB domain containing 1
HILPDA hypoxia inducible lipid droplet-associated
HYOU1 hypoxia up-regulated 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IGFBP5 insulin-like growth factor binding protein 5
KLHL41 kelch-like family member 41
KRT6A keratin 6A, type II
LDB3 LIM domain binding 3
LOC100505650 uncharacterized LOC100505650
MAP7 microtubule-associated protein 7
MB myoglobin
MTERF3 mitochondrial transcription termination factor 3
NEB nebulin
NNMT nicotinamide N-methyltransferase
PDE4DIP phosphodiesterase 4D interacting protein
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PRUNE2 prune homolog 2 (Drosophila)
RGCC regulator of cell cycle
RGS5 regulator of G-protein signaling 5
RPS5 ribosomal protein S5
RRAS2 related RAS viral (r-ras) oncogene homolog 2
RRP8 ribosomal RNA processing 8, methyltransferase, homolog (yeast)
SCGB2A1 secretoglobin, family 2A, member 1
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SLN sarcolipin
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TNNI2 troponin I type 2 (skeletal, fast)
TPM1 tropomyosin 1 (alpha)
TTN titin
TWIST1 twist family bHLH transcription factor 1
VCAM1 vascular cell adhesion molecule 1

decreased expression

Symbol Name
ACTN1 actinin, alpha 1
AREG amphiregulin
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1
C1ORF106 chromosome 1 open reading frame 106
CCL19 chemokine (C-C motif) ligand 19
CCNF cyclin F
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CHMP4A charged multivesicular body protein 4A
COL4A2 collagen, type IV, alpha 2
COL6A3 collagen, type VI, alpha 3
CTSH cathepsin H
CYR61 cysteine-rich, angiogenic inducer, 61
DKK1 dickkopf WNT signaling pathway inhibitor 1
FAM46A family with sequence similarity 46, member A
FOLR1 folate receptor 1 (adult)
IFI27 interferon, alpha-inducible protein 27
IGFBP7 insulin-like growth factor binding protein 7
IL7R interleukin 7 receptor
IRS2 insulin receptor substrate 2
ITGA6 integrin, alpha 6
KIF14 kinesin family member 14
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MGP matrix Gla protein
NT5E 5'-nucleotidase, ecto (CD73)
PLA2G16 phospholipase A2, group XVI
PLAC8 placenta-specific 8
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PNMA1 paraneoplastic Ma antigen 1
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SLC22A3 solute carrier family 22 (organic cation transporter), member 3
SOX9 SRY (sex determining region Y)-box 9
SPOP speckle-type POZ protein
SPTBN1 spectrin, beta, non-erythrocytic 1
SRC SRC proto-oncogene, non-receptor tyrosine kinase
TFPI2 tissue factor pathway inhibitor 2
TGFBI transforming growth factor, beta-induced, 68kDa
TMC5 transmembrane channel-like 5
TOP2A topoisomerase (DNA) II alpha 170kDa