BRD-K91836367_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

93 genes differentially expressed following the BRD-K91836367_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
BEX4 brain expressed, X-linked 4
BID BH3 interacting domain death agonist
CA2 carbonic anhydrase II
CAST calpastatin
CD200 CD200 molecule
CDS1 CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1
CECR1 cat eye syndrome chromosome region, candidate 1
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
COL5A2 collagen, type V, alpha 2
CRABP2 cellular retinoic acid binding protein 2
CTBP2 C-terminal binding protein 2
EGF epidermal growth factor
EIF5A eukaryotic translation initiation factor 5A
FAM49A family with sequence similarity 49, member A
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FUT1 fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group)
HIST1H2BG histone cluster 1, H2bg
HOXB2 homeobox B2
IGFBP5 insulin-like growth factor binding protein 5
IGKC immunoglobulin kappa constant
JCHAIN joining chain of multimeric IgA and IgM
KLHL9 kelch-like family member 9
LRRC15 leucine rich repeat containing 15
LRRC17 leucine rich repeat containing 17
MEF2C myocyte enhancer factor 2C
MSN moesin
MYO1B myosin IB
NEB nebulin
NLGN4X neuroligin 4, X-linked
NPTX2 neuronal pentraxin II
NR1H2 nuclear receptor subfamily 1, group H, member 2
OAT ornithine aminotransferase
PEX11A peroxisomal biogenesis factor 11 alpha
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
REEP1 receptor accessory protein 1
RGCC regulator of cell cycle
SC5D sterol-C5-desaturase
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SFRP4 secreted frizzled-related protein 4
SST somatostatin
SVIL supervillin
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TRIB2 tribbles pseudokinase 2
TRIM2 tripartite motif containing 2
UBQLN2 ubiquilin 2
VTCN1 V-set domain containing T cell activation inhibitor 1
WARS tryptophanyl-tRNA synthetase
WLS wntless Wnt ligand secretion mediator
ZSCAN31 zinc finger and SCAN domain containing 31

decreased expression

Symbol Name
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ACSL5 acyl-CoA synthetase long-chain family member 5
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALOX5AP arachidonate 5-lipoxygenase-activating protein
AMDHD2 amidohydrolase domain containing 2
CA12 carbonic anhydrase XII
CCDC85B coiled-coil domain containing 85B
CHPT1 choline phosphotransferase 1
CLU clusterin
CSK c-src tyrosine kinase
CTTN cortactin
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL8 chemokine (C-X-C motif) ligand 8
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
ECI2 enoyl-CoA delta isomerase 2
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
ENO2 enolase 2 (gamma, neuronal)
F5 coagulation factor V (proaccelerin, labile factor)
FABP5 fatty acid binding protein 5 (psoriasis-associated)
GRIA2 glutamate receptor, ionotropic, AMPA 2
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IGFBP4 insulin-like growth factor binding protein 4
IL6R interleukin 6 receptor
LAMC1 laminin, gamma 1 (formerly LAMB2)
MET MET proto-oncogene, receptor tyrosine kinase
MGLL monoglyceride lipase
MSRB2 methionine sulfoxide reductase B2
MTCL1 microtubule crosslinking factor 1
MYCBP MYC binding protein
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NNMT nicotinamide N-methyltransferase
PCOLCE2 procollagen C-endopeptidase enhancer 2
PEBP1 phosphatidylethanolamine binding protein 1
RAD51C RAD51 paralog C
TESC tescalcin
TLR4 toll-like receptor 4
TRAK1 trafficking protein, kinesin binding 1
UBE2E1 ubiquitin-conjugating enzyme E2E 1