BRD-K91701654_70970_VCAP_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

176 genes differentially expressed following the BRD-K91701654_70970_VCAP_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
ADD3 adducin 3 (gamma)
ADO 2-aminoethanethiol (cysteamine) dioxygenase
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AKAP8 A kinase (PRKA) anchor protein 8
ALB albumin
ALDOB aldolase B, fructose-bisphosphate
ARPP19 cAMP-regulated phosphoprotein, 19kDa
ATXN1 ataxin 1
BAG3 BCL2-associated athanogene 3
BEX4 brain expressed, X-linked 4
BRD4 bromodomain containing 4
CCND2 cyclin D2
CHERP calcium homeostasis endoplasmic reticulum protein
CLC Charcot-Leyden crystal galectin
COL15A1 collagen, type XV, alpha 1
CRABP2 cellular retinoic acid binding protein 2
CXCL8 chemokine (C-X-C motif) ligand 8
DEFA4 defensin, alpha 4, corticostatin
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
EREG epiregulin
FABP1 fatty acid binding protein 1, liver
FAM3C family with sequence similarity 3, member C
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GLS glutaminase
GPM6A glycoprotein M6A
GSTM3 glutathione S-transferase mu 3 (brain)
HHEX hematopoietically expressed homeobox
HIST1H1C histone cluster 1, H1c
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPD1 heat shock 60kDa protein 1 (chaperonin)
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
KCTD12 potassium channel tetramerization domain containing 12
LAMP1 lysosomal-associated membrane protein 1
LGALS2 lectin, galactoside-binding, soluble, 2
LOC100505650 uncharacterized LOC100505650
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MAST3 microtubule associated serine/threonine kinase 3
MEF2C myocyte enhancer factor 2C
MEX3C mex-3 RNA binding family member C
MICB MHC class I polypeptide-related sequence B
MS4A3 membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)
MXI1 MAX interactor 1, dimerization protein
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
PCDH9 protocadherin 9
PDZK1 PDZ domain containing 1
PEG3 paternally expressed 3
POSTN periostin, osteoblast specific factor
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTP4A1 protein tyrosine phosphatase type IVA, member 1
QPRT quinolinate phosphoribosyltransferase
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
RNMT RNA (guanine-7-) methyltransferase
RSL1D1 ribosomal L1 domain containing 1
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SMNDC1 survival motor neuron domain containing 1
SNX10 sorting nexin 10
SPON1 spondin 1, extracellular matrix protein
SPRY2 sprouty homolog 2 (Drosophila)
SST somatostatin
STC2 stanniocalcin 2
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa
TIMP3 TIMP metallopeptidase inhibitor 3
UBE2E3 ubiquitin-conjugating enzyme E2E 3
WT1 Wilms tumor 1
XIST X inactive specific transcript (non-protein coding)
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)
ZFP36L2 ZFP36 ring finger protein-like 2

decreased expression

Symbol Name
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ACPP acid phosphatase, prostate
ACTG2 actin, gamma 2, smooth muscle, enteric
AGTR1 angiotensin II receptor, type 1
AIM1 absent in melanoma 1
ALCAM activated leukocyte cell adhesion molecule
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
AQP3 aquaporin 3 (Gill blood group)
BASP1 brain abundant, membrane attached signal protein 1
BLVRA biliverdin reductase A
C2CD5 C2 calcium-dependent domain containing 5
CANT1 calcium activated nucleotidase 1
CCNB2 cyclin B2
CDC25B cell division cycle 25B
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CENPU centromere protein U
CIRBP cold inducible RNA binding protein
COL1A2 collagen, type I, alpha 2
COPS3 COP9 signalosome subunit 3
CREB3L1 cAMP responsive element binding protein 3-like 1
CSRP1 cysteine and glycine-rich protein 1
DBT dihydrolipoamide branched chain transacylase E2
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DES desmin
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
ERBB2 erb-b2 receptor tyrosine kinase 2
FAM57A family with sequence similarity 57, member A
FOLH1 folate hydrolase (prostate-specific membrane antigen) 1
FSTL1 follistatin-like 1
GALNT7 polypeptide N-acetylgalactosaminyltransferase 7
GLRX glutaredoxin (thioltransferase)
HDAC1 histone deacetylase 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HOXC6 homeobox C6
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IGFBP6 insulin-like growth factor binding protein 6
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
KDM5D lysine (K)-specific demethylase 5D
KIAA0101 KIAA0101
KLK2 kallikrein-related peptidase 2
KLK3 kallikrein-related peptidase 3
KRT15 keratin 15, type I
LBR lamin B receptor
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LIG1 ligase I, DNA, ATP-dependent
LIMCH1 LIM and calponin homology domains 1
LOXL1 lysyl oxidase-like 1
MAGED2 melanoma antigen family D2
MATN2 matrilin 2
MCM5 minichromosome maintenance complex component 5
MLPH melanophilin
MSMB microseminoprotein, beta-
MT2A metallothionein 2A
MYH11 myosin, heavy chain 11, smooth muscle
NANS N-acetylneuraminic acid synthase
NCAPG non-SMC condensin I complex, subunit G
NKX3-1 NK3 homeobox 1
NMU neuromedin U
NPY neuropeptide Y
NRN1 neuritin 1
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1
NUP88 nucleoporin 88kDa
ODC1 ornithine decarboxylase 1
PCNA proliferating cell nuclear antigen
PDGFA platelet-derived growth factor alpha polypeptide
PDLIM5 PDZ and LIM domain 5
PEMT phosphatidylethanolamine N-methyltransferase
PIR pirin (iron-binding nuclear protein)
PLA1A phospholipase A1 member A
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPIE peptidylprolyl isomerase E (cyclophilin E)
PSIP1 PC4 and SFRS1 interacting protein 1
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7
RAP1GAP RAP1 GTPase activating protein
RPL37A ribosomal protein L37a
RPL38 ribosomal protein L38
RPS11 ribosomal protein S11
RPS4Y1 ribosomal protein S4, Y-linked 1
RRM1 ribonucleotide reductase M1
SELENBP1 selenium binding protein 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1
SMS spermine synthase
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPDEF SAM pointed domain containing ETS transcription factor
SRSF5 serine/arginine-rich splicing factor 5
TARP TCR gamma alternate reading frame protein
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TMSB15A thymosin beta 15a
TOX3 TOX high mobility group box family member 3
TPM2 tropomyosin 2 (beta)
TRIM16 tripartite motif containing 16
TRMT5 tRNA methyltransferase 5
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
USP22 ubiquitin specific peptidase 22
XBP1 X-box binding protein 1
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon