BRD-K91509126_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

85 genes differentially expressed following the BRD-K91509126_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
ACP5 acid phosphatase 5, tartrate resistant
AMIGO2 adhesion molecule with Ig-like domain 2
BST2 bone marrow stromal cell antigen 2
C8ORF4 chromosome 8 open reading frame 4
CA12 carbonic anhydrase XII
CAPN3 calpain 3, (p94)
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
EFHD1 EF-hand domain family, member D1
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
ERLIN2 ER lipid raft associated 2
G0S2 G0/G1 switch 2
GBE1 glucan (1,4-alpha-), branching enzyme 1
GCLM glutamate-cysteine ligase, modifier subunit
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMOX1 heme oxygenase 1
IGHD immunoglobulin heavy constant delta
IGKV4-1 immunoglobulin kappa variable 4-1
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15
KRCC1 lysine-rich coiled-coil 1
LDLR low density lipoprotein receptor
LTBP2 latent transforming growth factor beta binding protein 2
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MT1X metallothionein 1X
MT2A metallothionein 2A
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MUC5B mucin 5B, oligomeric mucus/gel-forming
NPC1 Niemann-Pick disease, type C1
NQO1 NAD(P)H dehydrogenase, quinone 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SELENBP1 selenium binding protein 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC38A6 solute carrier family 38, member 6
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SQSTM1 sequestosome 1
THBD thrombomodulin
TXNRD1 thioredoxin reductase 1
UFM1 ubiquitin-fold modifier 1
WIPI1 WD repeat domain, phosphoinositide interacting 1
ZNF586 zinc finger protein 586

decreased expression

Symbol Name
ACTG2 actin, gamma 2, smooth muscle, enteric
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
APOA1 apolipoprotein A-I
APOA2 apolipoprotein A-II
APOB apolipoprotein B
CCL20 chemokine (C-C motif) ligand 20
CCND2 cyclin D2
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CPE carboxypeptidase E
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXADR coxsackie virus and adenovirus receptor
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
DLK1 delta-like 1 homolog (Drosophila)
FHL1 four and a half LIM domains 1
FSD1 fibronectin type III and SPRY domain containing 1
GPC3 glypican 3
GRIA2 glutamate receptor, ionotropic, AMPA 2
HOXB6 homeobox B6
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
MEIS1 Meis homeobox 1
MTSS1 metastasis suppressor 1
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NPTX2 neuronal pentraxin II
PGAM1 phosphoglycerate mutase 1 (brain)
POSTN periostin, osteoblast specific factor
REEP1 receptor accessory protein 1
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
RTN1 reticulon 1
SCG2 secretogranin II
SERINC5 serine incorporator 5
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
TGFBI transforming growth factor, beta-induced, 68kDa
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TLR4 toll-like receptor 4
TMEM158 transmembrane protein 158 (gene/pseudogene)
TPM1 tropomyosin 1 (alpha)
VNN1 vanin 1