BRD-K91442916_CAM-9-026 BRD-K91442916_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

172 genes differentially expressed following the BRD-K91442916_CAM-9-026 BRD-K91442916_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADM adrenomedullin
ALB albumin
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BGN biglycan
BLNK B-cell linker
CAST calpastatin
CD44 CD44 molecule (Indian blood group)
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHST1 carbohydrate (keratan sulfate Gal-6) sulfotransferase 1
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CKAP4 cytoskeleton-associated protein 4
CPE carboxypeptidase E
CRABP1 cellular retinoic acid binding protein 1
CRISP3 cysteine-rich secretory protein 3
DHRS3 dehydrogenase/reductase (SDR family) member 3
DHRS9 dehydrogenase/reductase (SDR family) member 9
DLK1 delta-like 1 homolog (Drosophila)
DUSP6 dual specificity phosphatase 6
FAM129A family with sequence similarity 129, member A
FGL2 fibrinogen-like 2
FRZB frizzled-related protein
GPC3 glypican 3
GPR37 G protein-coupled receptor 37 (endothelin receptor type B-like)
HEBP2 heme binding protein 2
HIST1H2BG histone cluster 1, H2bg
HOXB2 homeobox B2
HP haptoglobin
HSPA2 heat shock 70kDa protein 2
IER5 immediate early response 5
INSR insulin receptor
KIAA1033 KIAA1033
KLHDC10 kelch domain containing 10
KRT23 keratin 23, type I
LPAR6 lysophosphatidic acid receptor 6
LTF lactotransferrin
MEIS1 Meis homeobox 1
MEIS2 Meis homeobox 2
MMP12 matrix metallopeptidase 12
MMP9 matrix metallopeptidase 9
MX1 MX dynamin-like GTPase 1
NFE2 nuclear factor, erythroid 2
NPTX2 neuronal pentraxin II
ORM1 orosomucoid 1
PBX3 pre-B-cell leukemia homeobox 3
PDIA3 protein disulfide isomerase family A, member 3
PELI1 pellino E3 ubiquitin protein ligase 1
PLK2 polo-like kinase 2
PON3 paraoxonase 3
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTPRO protein tyrosine phosphatase, receptor type, O
PYCARD PYD and CARD domain containing
QPRT quinolinate phosphoribosyltransferase
RBP1 retinol binding protein 1, cellular
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RGCC regulator of cell cycle
RGS5 regulator of G-protein signaling 5
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RPS4Y1 ribosomal protein S4, Y-linked 1
RTN2 reticulon 2
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SAT1 spermidine/spermine N1-acetyltransferase 1
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SCGB2A2 secretoglobin, family 2A, member 2
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SRRM2 serine/arginine repetitive matrix 2
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TF transferrin
TMEM158 transmembrane protein 158 (gene/pseudogene)
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TRIB2 tribbles pseudokinase 2
TRIM2 tripartite motif containing 2
TUBB2A tubulin, beta 2A class IIa
TYMP thymidine phosphorylase
VEGFA vascular endothelial growth factor A
ZFP36L1 ZFP36 ring finger protein-like 1
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADCY1 adenylate cyclase 1 (brain)
ADIRF adipogenesis regulatory factor
AGR2 anterior gradient 2
AKAP11 A kinase (PRKA) anchor protein 11
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
APOD apolipoprotein D
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2
AREG amphiregulin
ATF1 activating transcription factor 1
ATMIN ATM interactor
ATP5S ATP synthase, H+ transporting, mitochondrial Fo complex, subunit s (factor B)
AVL9 AVL9 homolog (S. cerevisiase)
BASP1 brain abundant, membrane attached signal protein 1
BMI1 BMI1 proto-oncogene, polycomb ring finger
CA12 carbonic anhydrase XII
CBX3 chromobox homolog 3
CCL19 chemokine (C-C motif) ligand 19
CCNE2 cyclin E2
CDC42 cell division cycle 42
CFD complement factor D (adipsin)
CLU clusterin
COX11 COX11 cytochrome c oxidase copper chaperone
CTTN cortactin
CXCL13 chemokine (C-X-C motif) ligand 13
DLD dihydrolipoamide dehydrogenase
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EGR3 early growth response 3
ENO1 enolase 1, (alpha)
EPB41L2 erythrocyte membrane protein band 4.1-like 2
ERBB3 erb-b2 receptor tyrosine kinase 3
FERMT1 fermitin family member 1
FOLR1 folate receptor 1 (adult)
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GHR growth hormone receptor
GMNN geminin, DNA replication inhibitor
GPX3 glutathione peroxidase 3
GSTM3 glutathione S-transferase mu 3 (brain)
HACD2 3-hydroxyacyl-CoA dehydratase 2
HDGFRP3 hepatoma-derived growth factor, related protein 3
HN1 hematological and neurological expressed 1
HRSP12 heat-responsive protein 12
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
INSIG1 insulin induced gene 1
KCNK1 potassium channel, two pore domain subfamily K, member 1
KLF5 Kruppel-like factor 5 (intestinal)
LAPTM4B lysosomal protein transmembrane 4 beta
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LYPLA1 lysophospholipase I
MARCKSL1 MARCKS-like 1
MET MET proto-oncogene, receptor tyrosine kinase
MPZL1 myelin protein zero-like 1
MRPS30 mitochondrial ribosomal protein S30
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NOV nephroblastoma overexpressed
NRIP1 nuclear receptor interacting protein 1
PFDN4 prefoldin subunit 4
PHB prohibitin
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
POLR2K polymerase (RNA) II (DNA directed) polypeptide K, 7.0kDa
PPIF peptidylprolyl isomerase F
PRKCZ protein kinase C, zeta
RBM12 RNA binding motif protein 12
REEP5 receptor accessory protein 5
S100A13 S100 calcium binding protein A13
SACS sacsin molecular chaperone
SF1 splicing factor 1
SIK1 salt-inducible kinase 1
SLC16A7 solute carrier family 16 (monocarboxylate transporter), member 7
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC25A46 solute carrier family 25, member 46
SPATA20 spermatogenesis associated 20
SPEN spen family transcriptional repressor
SSR1 signal sequence receptor, alpha
SUMO2 small ubiquitin-like modifier 2
TFPI2 tissue factor pathway inhibitor 2
TMBIM6 transmembrane BAX inhibitor motif containing 6
TMX1 thioredoxin-related transmembrane protein 1
TOP2A topoisomerase (DNA) II alpha 170kDa
TSPAN13 tetraspanin 13
UBE3C ubiquitin protein ligase E3C
UBL3 ubiquitin-like 3
UFM1 ubiquitin-fold modifier 1
USP22 ubiquitin specific peptidase 22
XPO7 exportin 7
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
ZEB2 zinc finger E-box binding homeobox 2